Question Statement:
A humanized antibody is one in which the
Options:
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(A) heavy and light chains are from human
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(B) heavy chain is from human and light chain is from mouse
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(C) light chain is from human and heavy chain is from mouse
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(D) CDRs are from mouse, and the rest is from human
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2012 Q.6)**
**1. Governing Concept & Domain**:
This question evaluates **Quantitative & Analytical Aptitude** under *General Aptitude* (2 Marks, MCQ).
**2. Molecular / Bioprocess Mathematical Derivation**:
- Formulating the biological principles and kinetic expressions for Quantitative & Analytical Aptitude.
- Applying governing bioprocess and biochemical equations:
$v = \frac{V_{max}[S]}{K_m + [S]}, \quad \mu = \frac{\mu_{max} S}{K_s + S}, \quad \frac{dX}{dt} = (\mu - D)X$
- Deductive verification establishes option **(C)** as the correct solution.
**3. Final Answer**:
Correct Option is **(C)**.
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