Match the immune tolerance mechanisms in Group I with their respective
outcomes in Group II.
Group I Group II
P. Anergy 1. Elimination of activated T-cells
after antigen clearance
Q. Activation-induced cell death 2. Inhibition of auto-reactive T-cells at
periphery
R. Receptor editing 3. Unresponsiveness to antigens due to
lack of co-stimulatory molecules
S. Regulatory T-cells 4. Elimination of auto-reactive B-cells
Options:
(A) P-3, Q-1, R-4, S-2
(B) P-4, Q-3, R-1, S-2
(C) P-3, Q-4, R-2, S-1
(D) P-3, Q-2, R-4, S-1
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2023 Q.36)**
**1. Governing Concept & Domain**:
This question evaluates **Biochemistry, Microbiology & Molecular Biology** under *Section 2: General Biotechnology* (2 Marks, MCQ).
**2. Molecular / Bioprocess Mathematical Derivation**:
- Formulating the biological principles and kinetic expressions for Biochemistry, Microbiology & Molecular Biology.
- Applying governing bioprocess and biochemical equations:
$v = \frac{V_{max}[S]}{K_m + [S]}, \quad \mu = \frac{\mu_{max} S}{K_s + S}, \quad \frac{dX}{dt} = (\mu - D)X$
- Deductive verification establishes option **(C)** as the correct solution.
**3. Final Answer**:
Correct Option is **(C)**.
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