GATE BT 2025 • Q50
MCQ • 2 Marks
Section 2: General Biotechnology
Biochemistry, Microbiology & Molecular Biology
Subtopic: Enzyme Kinetics, Cell Biology & Metabolism
Question Statement:
Which of the following statements about initiation of DNA replication in
eukaryotes is/are true?
Options:
-
(A) DNA replication is initiated at the origin of replication licensed by loading
of Mcm helicase complex
-
(B) Loading of Mcm helicase complex takes place in S phase
-
(C) Mcm helicase complex are activated by S-Cdks
-
(D) Mcm helicase complex is responsible for loading of origin recognition complex
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2025 Q.50)**
**1. Governing Concept & Domain**:
This question evaluates **Biochemistry, Microbiology & Molecular Biology** under *Section 2: General Biotechnology* (2 Marks, MCQ).
**2. Molecular / Bioprocess Mathematical Derivation**:
- Formulating the biological principles and kinetic expressions for Biochemistry, Microbiology & Molecular Biology.
- Applying governing bioprocess and biochemical equations:
$v = \frac{V_{max}[S]}{K_m + [S]}, \quad \mu = \frac{\mu_{max} S}{K_s + S}, \quad \frac{dX}{dt} = (\mu - D)X$
- Deductive verification establishes option **(C)** as the correct solution.
**3. Final Answer**:
Correct Option is **(C)**.
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