GATE BT 2018 • Q13 NAT • 1 Mark

Section 4: Bioprocess Engineering & Process Biotechnology

Bioprocess Engineering

Subtopic: Bioreactor Design, Kinetics & Downstream Processing

Question Statement:

Which one of the following bioreactor configurations is the basis for a trickling biological filter? (A) Stirred tank (B) Packed bed (C) Air lift (D) Fluidized bed /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (3)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 711.09 33.99 76.59 re W* n /P <</MCID 0 >>BDC q 59.4 711.1 33.984 76.584 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.14)Tj ET Q q 59.4 711.1 33.984 76.584 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 711.1 33.984 76.584 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q q 93.39 746.25 452.13 41.43 re W* n /P <</MCID 1 >>BDC q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(C)-2 (e)4 (ll)-3 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 123.02 776.88 Td [(t)-11 (y)30 (p)-9 (e)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 143.54 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 147.38 776.88 Td [(A )-67 (se)3 (c)4 (r)-6 (e)4 (tes)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 197.81 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 201.65 776.88 Td [(mol)-3 (e)4 (c)4 (ule )-67 (X )-67 (int)-3 (o )-69 (the )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 302.95 776.88 Td [(c)4 (ult)-3 (ure)7 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 340.03 776.88 Td [(medium. )-71 (C)-2 (e)4 (ll)-3 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 410.11 776.88 Td [(t)-11 (y)30 (pe)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 430.54 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf -0.084 Tc 434.5 776.88 Td (B )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 446.26 776.88 Td [(in )-71 (the )-67 (sa)3 (me )-67 (c)4 (ult)-3 (ure)-2 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 763.08 Td [(re)7 (sponds )-31 (to )-31 (the )-27 (mol)-3 (e)4 (c)4 (ule)-7 ( )-29 (X )-27 (b)-9 (y)20 ( )-29 (e)4 (x)-9 (pre)7 (ssi)-3 (n)-9 (g)10 ( )-29 (prote)5 (in )-41 (Y)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 351.31 763.08 Td (.)Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 354.31 763.08 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 357.67 763.08 Td [(W)-5 (hich )-27 (one)4 ( )-29 (of )-26 (the )-27 (following)9 ( )-29 (modes )-28 (of)-6 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 749.26 Td [(sig)7 (na)4 (li)-3 (n)-9 (g)10 ( re)7 (p)-9 (re)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 170.66 749.26 Td [(se)3 (nts t)-4 (he)4 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 215.33 749.26 Td [(i)-11 (nter)5 (a)4 (c)4 (ti)-3 (on )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 269.69 749.26 Td [(be)4 (tw)-9 (e)4 (e)4 (n A )-7 (a)4 (n)-9 (d )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf -0.084 Tc 344.83 749.26 Td (B?)Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 358.15 749.26 Td ( )Tj ET EMC Q Q q 93.39 725.01 212.57 14.04 re W* n /P <</MCID 2 >>BDC q 93.384 725.02 212.57 14.04 re W* n BT /TT0 12 Tf 98.784 728.26 Td [(\(A)5 (\) A)5 (utoc)-7 (rine)5 ( )]TJ ET Q q 93.384 725.02 212.57 14.04 re W* n BT /TT0 12 Tf 169.46 728.26 Td ( )Tj ET EMC Q Q q 305.96 725.01 239.57 14.04 re W* n /P <</MCID 3 >>BDC q 305.95 725.02 239.57 14.04 re W* n BT /TT0 12 Tf 311.35 728.26 Td [(\(B)10 (\) J)-7 (ux)-9 (tac)6 (rine)5 ( )]TJ ET Q q 305.95 725.02 239.57 14.04 re W* n BT /TT0 12 Tf 382.63 728.26 Td ( )Tj ET EMC Q Q q 93.39 711.09 212.57 13.92 re W* n /P <</MCID 4 >>BDC q 93.384 711.1 212.57 13.92 re W* n BT /TT0 12 Tf 98.784 714.22 Td [(\(C\) Par)6 (a)4 (c)-5 (rine)5 ( )]TJ ET Q q 93.384 711.1 212.57 13.92 re W* n BT /TT0 12 Tf 166.1 714.22 Td ( )Tj ET EMC Q Q q 305.96 711.09 239.57 13.92 re W* n /P <</MCID 5 >>BDC q 305.95 711.1 239.57 13.92 re W* n BT /TT0 12 Tf 311.35 714.22 Td [(\(D)5 (\) )-6 (I)13 (ntr)-8 (a)4 (c)4 (rine)5 ( )]TJ ET Q q 305.95 711.1 239.57 13.92 re W* n BT /TT0 12 Tf 380.59 714.22 Td ( )Tj ET EMC Q Q BT /P <</MCID 6 >>BDC /TT0 11.04 Tf 54 701.14 Td ( )Tj EMC /P <</MCID 7 >>BDC 0 -12.72 Td ( )Tj EMC ET q 59.4 608.01 33.99 77.76 re W* n /P <</MCID 8 >>BDC q 59.4 608.02 33.984 77.76 re W* n BT /TT0 12 Tf 64.824 674.98 Td (Q.15)Tj ET Q q 59.4 608.02 33.984 77.76 re W* n BT /TT1 12 Tf 88.464 674.98 Td ( )Tj ET Q q 59.4 608.02 33.984 77.76 re W* n BT /TT0 12 Tf 100.82 674.98 Td ( )Tj ET EMC Q Q q 93.39 671.97 452.13 13.8 re W* n /P <</MCID 9 >>BDC q 93.384 671.98 452.14 13.8 re W* n BT /TT0 12 Tf 99.144 674.98 Td [(W)-5 (hich one)6 ( of the)5 ( following)9 ( state)3 (ments i)-2 (s true)4 ( )-9 (for)6 ( )-9 (a)4 (c)4 (ti)-3 (n?)]TJ ET Q q 93.384 671.98 452.14 13.8 re W* n BT /TT0 12 Tf 366.79 674.98 Td ( )Tj ET EMC Q Q q 93.39 650.97 452.13 13.8 re W* n /P <</MCID 10 >>BDC q 93.384 650.98 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 653.98 Td [(\(A)5 (\) A)5 (c)4 (ti)-3 (n fila)3 (ment is)-2 ( stru)-9 (c)4 (tura)5 (ll)-13 (y)20 ( pol)-11 (a)4 (riz)-4 (e)4 (d a)4 (nd the)-7 ( two e)4 (nds a)3 (re)7 ( not i)-3 (de)4 (nti)-3 (c)-5 (a)4 (l)]TJ ET Q q 93.384 650.98 452.14 13.8 re W* n BT /TT0 12 Tf 468.7 653.98 Td ( )Tj ET EMC Q Q q 93.39 637.17 452.13 13.8 re W* n /P <</MCID 11 >>BDC q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 640.18 Td [(\(B)10 (\) )]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf -0.024 Tc 117.74 640.18 Td (De)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf 131.66 640.18 Td ( )Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf 134.66 640.18 Td [(nov)4 (o)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 157.94 640.18 Td ( )Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 161.06 640.18 Td (a)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 166.34 640.18 Td [(c)4 (ti)-3 (n pol)-11 (y)20 (m)-11 (e)4 (riz)-4 (a)4 (ti)-3 (on is )-2 (a)4 ( sing)7 (le)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 310.99 640.18 Td (-)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 314.95 640.18 Td [(step )-8 (proc)7 (e)4 (ss)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 373.39 640.18 Td ( )Tj ET EMC Q Q q 93.39 623.37 452.13 13.8 re W* n /P <</MCID 12 >>BDC q 93.384 623.38 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 626.38 Td [(\(C\) T)4 (he)4 ( point)-3 (e)4 (d e)4 (nd of)3 ( th)-11 (e)4 ( a)4 (c)4 (ti)-3 (n fila)3 (ments i)-2 (s the f)4 (a)-5 (st g)7 (row)5 (in)-11 (g)10 ( e)4 (nd)]TJ ET Q q 93.384 623.38 452.14 13.8 re W* n BT /TT0 12 Tf 412.63 626.38 Td ( )Tj ET EMC Q Q q 93.39 608.01 452.13 15.36 re W* n /P <</MCID 13 >>BDC q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 98.784 612.58 Td [(\(D)5 (\) )]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 118.34 612.58 Td [(Ac)6 (ti)-3 (n fo)-6 (rms spi)-2 (ndle )]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 216.77 612.58 Td [(f)-6 (iber)5 (s)]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 244.13 612.58 Td ( )Tj ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 247.13 612.58 Td [(durin)-8 (g)10 ( mi)-3 (tosi)-4 (s)]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 316.15 612.58 Td ( )Tj ET EMC Q Q BT /P <</MCID 14 >>BDC /TT0 12 Tf 54 597.22 Td ( )Tj EMC /P <</MCID 15 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 499.63 33.99 80.775 re W* n /P <</MCID 16 >>BDC q 59.4 499.63 33.984 80.784 re W* n BT 64.824 569.62 Td (Q.16)Tj ET Q q 59.4 499.63 33.984 80.784 re W* n BT /TT1 12 Tf 88.464 569.62 Td ( )Tj ET Q q 59.4 499.63 33.984 80.784 re W* n BT 100.82 569.62 Td ( )Tj ET EMC Q Q q 93.39 566.61 452.13 13.8 re W* n /P <</MCID 17 >>BDC q 93.384 566.62 452.14 13.8 re W* n BT 99.144 569.62 Td [(S)-3 (tanda)6 (rd e)7 (rr)6 (o)-9 (r is)]TJ ET Q q 93.384 566.62 452.14 13.8 re W* n BT 179.18 569.62 Td ( )Tj ET EMC Q Q q 93.39 545.59 452.13 13.8 re W* n /P <</MCID 18 >>BDC q 93.384 545.59 452.14 13.8 re W* n BT 98.784 548.59 Td [(\(A)5 (\) the)5 ( prob)-6 (a)4 (bil)-3 (it)-13 (y)20 ( of )-6 (a)4 ( ty)18 (p)-9 (e)4 ( )-19 (I)13 ( e)4 (r)-6 (ror)6 ( in a sta)3 (ti)-3 (sti)-4 (c)4 (a)4 (l )-11 (test)]TJ ET Q q 93.384 545.59 452.14 13.8 re W* n BT 355.75 548.59 Td ( )Tj ET EMC Q Q q 93.39 531.79 452.13 13.8 re W* n /P <</MCID 19 >>BDC q 93.384 531.79 452.14 13.8 re W* n BT 98.784 534.79 Td (\()Tj ET Q q 93.384 531.79 452.14 13.8 re W* n BT 102.74 534.79 Td [(B)7 (\) the)5 ( )-9 (e)4 (rr)6 (o)-9 (r in e)5 (sti)-4 (mating)8 ( a)4 ( s)-10 (a)4 (mpl)-3 (e)4 ( standa)5 (rd d)-6 (e)4 (vi)-11 (a)4 (ti)-3 (on)]TJ ET Q q 93.384 531.79 452.14 13.8 re W* n BT 360.79 534.79 Td ( )Tj ET EMC Q Q q 93.39 518 452.13 13.8 re W* n /P <</MCID 20 >>BDC q 93.384 517.99 452.14 13.8 re W* n BT 98.784 520.99 Td [(\(C\) the)5 ( standa)5 (rd d)-6 (e)4 (viation of a)5 ( va)4 (ri)-8 (a)4 (ble tha)4 (t follo)-12 (ws standa)6 (rd no)3 (rma)5 (l di)-3 (stri)-11 (buti)-3 (on)]TJ ET Q q 93.384 517.99 452.14 13.8 re W* n BT 485.86 520.99 Td ( )Tj ET EMC Q Q q 93.39 499.64 452.13 18.36 re W* n /P <</MCID 21 >>BDC q 93.384 499.63 452.14 18.36 re W* n BT 98.784 507.19 Td [(\(D)5 (\) the)5 ( standa)-4 (rd de)7 (viatio)-11 (n of d)3 (ist)-4 (ributi)-2 (on of)3 ( sa)3 (mpl)-3 (e)4 ( mea)6 (ns)]TJ ET Q q 93.384 499.63 452.14 18.36 re W* n BT 379.51 507.19 Td ( )Tj ET EMC Q Q BT /P <</MCID 22 >>BDC 54 488.83 Td ( )Tj EMC /P <</MCID 23 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 378.28 33.99 93.75 re W* n /P <</MCID 24 >>BDC q 59.4 378.29 33.984 93.744 re W* n BT 64.824 461.23 Td (Q.17)Tj ET Q q 59.4 378.29 33.984 93.744 re W* n BT /TT1 12 Tf 88.464 461.23 Td ( )Tj ET Q q 59.4 378.29 33.984 93.744 re W* n BT 100.82 461.23 Td ( )Tj ET EMC Q Q q 93.39 444.43 452.13 27.6 re W* n /P <</MCID 25 >>BDC q 93.384 444.43 452.14 27.6 re W* n BT 99.144 461.23 Td [(W)-5 (hich one)6 ( of th)-8 (e)4 ( followi)-10 (ng)10 ( t)-11 (e)4 (c)4 (hniques is)-11 ( use)3 (d to)-11 ( )-9 (mo)]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 353.35 461.23 Td [(nit)-3 (or RNA)4 ( tra)5 (nsc)-6 (ripts)]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 457.42 461.23 Td (,)Tj ET Q q 93.384 444.43 452.14 27.6 re W* n BT 460.42 461.23 Td ( )Tj ET Q q 93.384 444.43 452.14 27.6 re W* n BT 463.42 461.23 Td [(both t)-3 (e)4 (mpora)5 (ll)-23 (y)20 ( )]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 99.144 447.43 Td [(a)4 (nd spa)3 (ti)-3 (a)4 (ll)-13 (y)30 (?)-15 ( )]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 168.5 447.43 Td ( )Tj ET EMC Q Q q 93.39 423.43 452.13 13.8 re W* n /P <</MCID 26 >>BDC q 93.384 423.43 452.14 13.8 re W* n BT 98.784 426.43 Td [(\(A)5 (\))]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT /TT1 12 Tf 115.46 426.43 Td ( )Tj ET Q q 93.384 423.43 452.14 13.8 re W* n BT 116.78 426.43 Td ( )Tj ET Q q 93.384 423.43 452.14 13.8 re W* n BT 119.78 426.43 Td [(Nor)5 (ther)5 (n b)]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT 171.98 426.43 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT 203.45 426.43 Td ( )Tj ET EMC Q Q q 93.39 409.63 452.13 13.8 re W* n /P <</MCID 27 >>BDC q 93.384 409.63 452.14 13.8 re W* n BT 98.784 412.63 Td [(\(B)10 (\))]TJ ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 412.63 Td ( )Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT2 12 Tf 116.78 412.63 Td (In s)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT2 12 Tf 0.024 Tc 134.42 412.63 Td (itu)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 147.14 412.63 Td ( )Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 150.14 412.63 Td (h)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 156.26 412.63 Td [(y)20 (bridiz)-6 (a)4 (ti)-3 (on)]TJ ET Q q 93.384 409.63 452.14 13.8 re W* n BT 214.13 412.63 Td ( )Tj ET EMC Q Q q 93.39 395.83 452.13 13.8 re W* n /P <</MCID 28 >>BDC q 93.384 395.83 452.14 13.8 re W* n BT 98.784 398.83 Td (\(C\))Tj ET Q q 93.384 395.83 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 398.83 Td ( )Tj ET Q q 93.384 395.83 452.14 13.8 re W* n BT 116.78 398.83 Td [(S)-3 (outher)5 (n b)]TJ ET Q q 93.384 395.83 452.14 13.8 re W* n BT 169.1 398.83 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 395.83 452.14 13.8 re W* n BT 200.45 398.83 Td ( )Tj ET EMC Q Q q 93.39 378.28 452.13 17.55 re W* n /P <</MCID 29 >>BDC q 93.384 378.29 452.14 17.544 re W* n BT 98.784 385.03 Td [(\(D)5 (\))]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT /TT1 12 Tf 115.46 385.03 Td ( )Tj ET Q q 93.384 378.29 452.14 17.544 re W* n BT 116.78 385.03 Td [(W)-5 (e)4 (ster)4 (n b)]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT 165.74 385.03 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT 197.09 385.03 Td ( )Tj ET EMC Q Q BT /P <</MCID 30 >>BDC 54 367.49 Td ( )Tj EMC /P <</MCID 31 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 232.6 33.99 118.08 re W* n /P <</MCID 32 >>BDC q 59.4 232.61 33.984 118.08 re W* n BT 64.824 339.89 Td (Q.18)Tj ET Q q 59.4 232.61 33.984 118.08 re W* n BT /TT1 12 Tf 88.464 339.89 Td ( )Tj ET Q q 59.4 232.61 33.984 118.08 re W* n BT 100.82 339.89 Td ( )Tj ET EMC Q Q /P <</MCID 33 >>BDC q 93.39 267.89 452.13 82.797 re W* n BT 99.144 339.89 Td [(I)13 (d)-9 (e)4 (nti)-3 (f)-16 (y)20 ( the c)6 (h)-9 (a)4 (ra)-2 (c)4 (ter)5 ( ba)4 (s)-10 (e)4 (d method\()3 (s\) use)5 (d )-9 (for)6 ( the)-7 ( c)4 (onst)-2 (ruc)7 (ti)-3 (on of)3 ( a)4 ( ph)-19 (y)20 (lo)-11 (ge)4 (ne)4 (ti)-3 (c)4 ( tre)-4 (e)4 (.)]TJ ET Q q 93.39 267.89 452.13 82.797 re W* n BT 516.1 339.89 Td ( )Tj ET EMC Q /P <</MCID 34 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 326.09 Td ( )Tj ET EMC Q /P <</MCID 35 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 312.29 Td [(P)-3 (. Ma)3 (x)-9 (im)-3 (u)10 (m par)5 (sim)-4 (on)-9 (y)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 215.45 312.29 Td ( )Tj ET EMC Q /P <</MCID 36 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT -0.024 Tc 99.144 298.49 Td (Q.)Tj ET Q q 93.39 267.88 452.13 82.8 re W* n BT 110.78 298.49 Td ( )Tj ET Q q 93.39 267.88 452.13 82.8 re W* n BT 113.78 298.49 Td [(Ne)6 (i)-11 (g)10 (hbor )3 (joi)-3 (ning)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 196.13 298.49 Td ( )Tj ET EMC Q /P <</MCID 37 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 284.69 Td [(R)-2 (. Ma)3 (x)-9 (im)-3 (u)10 (m l)-3 (ikelihood)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 214.97 284.69 Td ( )Tj ET EMC Q /P <</MCID 38 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 270.89 Td [(S)-3 (. B)7 (ootst)-4 (ra)7 (pping)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 179.81 270.89 Td ( )Tj ET EMC Q q 93.39 246.64 212.57 14.04 re W* n /P <</MCID 39 >>BDC q 93.384 246.65 212.57 14.04 re W* n BT 98.784 249.89 Td [(\(A)5 (\) )]TJ ET Q q 93.384 246.65 212.57 14.04 re W* n BT 118.34 249.89 Td (Q)Tj ET Q q 93.384 246.65 212.57 14.04 re W* n BT 126.98 249.89 Td ( )Tj ET Q q 93.384 246.65 212.57 14.04 re W* n BT 129.98 249.89 Td [(onl)-21 (y)]TJ ET Q q 93.384 246.65 212.57 14.04 re W* n BT 151.46 249.89 Td ( )Tj ET EMC Q Q q 305.96 246.64 239.57 14.04 re W* n /P <</MCID 40 >>BDC q 305.95 246.65 239.57 14.04 re W* n BT 311.35 249.89 Td [(\(B)10 (\) P an)3 (d R)-2 ( onl)-21 (y)]TJ ET Q q 305.95 246.65 239.57 14.04 re W* n BT 392.71 249.89 Td ( )Tj ET EMC Q Q q 93.39 232.6 212.57 14.04 re W* n /P <</MCID 41 >>BDC q 93.384 232.61 212.57 14.04 re W* n BT 98.784 235.85 Td (\(C\) )Tj ET Q q 93.384 232.61 212.57 14.04 re W* n BT 117.74 235.85 Td [(Q a)6 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 232.61 212.57 14.04 re W* n BT 180.77 235.85 Td ( )Tj ET EMC Q Q q 305.96 232.6 239.57 14.04 re W* n /P <</MCID 42 >>BDC q 305.95 232.61 239.57 14.04 re W* n BT 311.35 235.85 Td [(\(D)5 (\))]TJ ET Q q 305.95 232.61 239.57 14.04 re W* n BT 327.91 235.85 Td ( )Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 330.91 235.85 Td (S)Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 337.63 235.85 Td ( )Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 340.63 235.85 Td [(onl)-11 (y)]TJ ET Q q 305.95 232.61 239.57 14.04 re W* n BT 361.99 235.85 Td ( )Tj ET EMC Q Q BT /P <</MCID 43 >>BDC 54 221.81 Td ( )Tj EMC /P <</MCID 44 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 154.35 33.99 50.655 re W* n /P <</MCID 45 >>BDC q 59.4 154.34 33.984 50.664 re W* n BT 64.824 194.18 Td (Q.19)Tj ET Q q 59.4 154.34 33.984 50.664 re W* n BT /TT1 12 Tf 88.464 194.18 Td ( )Tj ET Q q 59.4 154.34 33.984 50.664 re W* n BT 100.82 194.18 Td ( )Tj ET EMC Q Q q 93.39 176.31 452.13 28.695 re W* n /P <</MCID 46 >>BDC q 93.384 176.3 452.14 28.704 re W* n BT 99.144 193.7 Td [(W)-5 (hich )-47 (one)4 ( )-49 (of)]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 165.62 193.7 Td ( )Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 169.22 193.7 Td [(the )-47 (following)9 ( )-49 (is )-52 (the )-47 (solut)-4 (ion)]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 306.31 193.7 Td ( )Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 309.91 193.7 Td (for)Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 323.83 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 326.47 193.7 Td [<073F074B>3 <074F>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 344.47 198.14 Td <0B36>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 349.87 193.7 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 356.71 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 361.99 193.7 Td <0D45>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 373.63 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 376.27 193.7 Td <0374>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 382.87 193.7 Td [<073F074B>3 <074F0754>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 407.11 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 412.39 193.7 Td <0D45>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 424.06 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 426.7 193.7 Td <0373>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 433.3 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 439.3 193.7 Td <0D4C>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 451.66 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 454.3 193.7 Td <0372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 460.9 193.7 Td <2C>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 463.9 193.7 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 467.5 193.7 Td [<666F>-6 <7220>-46 <7661>4 <6C75657320>-48 <6F6620>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 533.02 193.7 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 539.76 193.7 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 99.144 179.18 Td [<696E2074>-3 <6865>4 <207261>7 <6E>-9 <67>10 <65>4 <206F66>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 168.62 179.18 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 171.62 179.18 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 174.74 179.18 Td <0372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 181.37 183.62 Td <03B9>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 188.45 179.18 Td <0D4F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 200.81 179.18 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 210.89 179.18 Td <0D4F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf -0.048 Tc 223.25 179.18 Td <037503780372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 243.05 183.62 Td <03B9>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 246.77 179.18 Td <3F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 252.17 179.18 Td <20>Tj ET EMC Q Q q 93.39 154.35 106.22 14.76 re W* n /P <</MCID 47 >>BDC q 93.384 154.34 106.22 14.76 re W* n BT 98.784 157.34 Td [<2841>5 <2920>]TJ ET Q q 93.384 154.34 106.22 14.76 re W* n BT 118.34 157.34 Td <3435>Tj ET Q q 93.384 154.34 106.22 14.76 re W* n BT /C0_0 12 Tf 130.34 157.34 Td <0071>Tj ET Q q 93.384 154.34 106.22 14.76 re W* n BT 135.26 157.34 Td <20>Tj ET EMC Q Q q 199.61 154.35 106.35 14.76 re W* n /P <</MCID 48 >>BDC q 199.61 154.34 106.34 14.76 re W* n BT 205.01 157.34 Td [<2842>10 <29203930>]TJ ET Q q 199.61 154.34 106.34 14.76 re W* n BT /C0_0 12 Tf 235.85 157.34 Td <0071>Tj ET Q q 199.61 154.34 106.34 14.76 re W* n BT 240.77 157.34 Td <20>Tj ET EMC Q Q q 305.96 154.35 106.2 14.76 re W* n /P <</MCID 49 >>BDC q 305.95 154.34 106.2 14.76 re W* n BT 311.35 157.34 Td <2843292020>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT 333.31 157.34 Td <313830>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT /C0_0 12 Tf 351.31 157.34 Td <0071>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT 356.11 157.34 Td <20>Tj ET EMC Q Q q 412.16 154.35 133.36 14.76 re W* n /P <</MCID 50 >>BDC q 412.15 154.34 133.37 14.76 re W* n BT 417.55 157.34 Td [<2844>5 <292020323730>]TJ ET Q q 412.15 154.34 133.37 14.76 re W* n BT /C0_0 12 Tf 458.14 157.34 Td <0071>Tj ET Q q 412.15 154.34 133.37 14.76 re W* n BT 463.06 157.34 Td <20>Tj ET EMC Q Q BT /P <</MCID 51 >>BDC 54 143.54 Td <20>Tj EMC /P <</MCID 52 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 86.91 33.99 39.84 re W* n /P <</MCID 53 >>BDC q 59.4 86.904 33.984 39.84 re W* n BT 64.824 115.94 Td <512E3230>Tj ET Q q 59.4 86.904 33.984 39.84 re W* n BT /TT1 12 Tf 88.464 115.94 Td ( )Tj ET Q q 59.4 86.904 33.984 39.84 re W* n BT 100.82 115.94 Td ( )Tj ET EMC Q Q q 93.39 112.95 452.13 13.8 re W* n /P <</MCID 54 >>BDC q 93.384 112.94 452.14 13.8 re W* n BT 99.144 115.94 Td [(W)-5 (hich one)6 ( of the)5 ( following)9 ( )]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 234.65 115.94 Td [(plant se)-6 (c)4 (onda)4 (r)-16 (y)20 ( m)-11 (e)4 (ta)]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 336.79 115.94 Td [(boli)-3 (tes is a na)6 (tura)5 (l i)-3 (nse)3 (c)4 (ti)-3 (c)4 (ide)]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 478.66 115.94 Td (?)Tj ET Q q 93.384 112.94 452.14 13.8 re W* n BT 484.06 115.94 Td ( )Tj ET EMC Q Q q 93.39 86.91 106.22 18.84 re W* n /P <</MCID 55 >>BDC q 93.384 86.904 106.22 18.84 re W* n BT 98.784 94.944 Td [(\(A)5 (\) )]TJ ET Q q 93.384 86.904 106.22 18.84 re W* n BT 118.34 94.944 Td [(Di)-9 (g)10 (it)-3 (ox)-9 (in)]TJ ET Q q 93.384 86.904 106.22 18.84 re W* n BT 164.42 94.944 Td ( )Tj ET EMC Q Q q 199.61 86.91 106.35 18.84 re W* n /P <</MCID 56 >>BDC q 199.61 86.904 106.34 18.84 re W* n BT 205.01 94.944 Td [(\(B)10 (\) )]TJ ET Q q 199.61 86.904 106.34 18.84 re W* n BT 223.85 94.944 Td [(P)-23 (y)20 (r)-6 (e)4 (thrin)]TJ ET Q q 199.61 86.904 106.34 18.84 re W* n BT 268.73 94.944 Td ( )Tj ET EMC Q Q q 305.96 86.91 106.2 18.84 re W* n /P <</MCID 57 >>BDC q 305.95 86.904 106.2 18.84 re W* n BT 311.35 94.944 Td (\(C\) )Tj ET Q q 305.95 86.904 106.2 18.84 re W* n BT 330.31 94.944 Td [(S)-3 (a)4 (li)-3 (c)-5 (y)]TJ ET Q q 305.95 86.904 106.2 18.84 re W* n BT 360.19 94.944 Td [(li)-3 (c)4 ( )-9 (a)4 (c)4 (i)]TJ ET Q q 305.95 86.904 106.2 18.84 re W* n BT 389.23 94.944 Td (d)Tj ET Q q 305.95 86.904 106.2 18.84 re W* n BT 395.35 94.944 Td ( )Tj ET EMC Q Q q 412.16 86.91 133.36 18.84 re W* n /P <</MCID 58 >>BDC q 412.15 86.904 133.37 18.84 re W* n BT 417.55 94.944 Td [(\(D)5 (\) )]TJ ET Q q 412.15 86.904 133.37 18.84 re W* n BT 437.14 94.944 Td [(Ave)6 (n)-9 (a)4 (c)4 (in A)]TJ ET Q q 412.15 86.904 133.37 18.84 re W* n BT 494.86 94.944 Td (-)Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 498.82 94.944 Td (1)Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 504.82 94.944 Td ( )Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 510.94 94.944 Td ( )Tj ET EMC Q Q BT /P <</MCID 59 >>BDC 54 76.104 Td ( )Tj EMC /P <</MCID 60 >>BDC 0 -13.8 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (4)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 737.61 33.99 50.07 re W* n /P <</MCID 0 >>BDC q 59.4 737.62 33.984 50.064 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.21)Tj ET Q q 59.4 737.62 33.984 50.064 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 737.62 33.984 50.064 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q /P <</MCID 1 >>BDC q 93.39 737.62 452.13 50.064 re W* n BT /TT0 12 Tf 99.144 766.44 Td [(The)5 ( de)4 (ter)5 (mi)-3 (na)4 (nt of th)-10 (e)4 ( matr)3 (ix)]TJ ET Q q 93.39 737.62 452.13 50.064 re W* n BT /TT0 12 Tf 243.17 766.44 Td ( )Tj ET EMC Q /P <</MCID 2 >>BDC q 0.70347 0 0 0.50347 246.06 751.37 cm /GS0 gs /TT0 8.04 Tf 0 TL/Fm0 Do Q EMC /P <</MCID 3 >>BDC q 93.39 737.62 452.13 50.064 re W* n BT /GS1 gs /TT0 12 Tf 296.69 766.44 Td ( )Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 0.024 Tc 299.71 766.44 Td (is)Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 307.75 766.44 Td ( )Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 310.75 766.44 Td (_________)Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 364.75 766.44 Td ( )Tj ET EMC Q /P <</MCID 4 >>BDC q 93.39 737.61 452.13 50.07 re W* n BT /GS0 gs /TT0 12 Tf 99.144 740.62 Td ( )Tj ET EMC Q BT /P <</MCID 5 >>BDC /GS0 gs /TT0 12 Tf 54 719.62 Td ( )Tj EMC /P <</MCID 6 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 660.69 33.99 42.12 re W* n /P <</MCID 7 >>BDC q 59.4 660.7 33.984 42.12 re W* n BT 64.824 692.02 Td (Q.22)Tj ET Q q 59.4 660.7 33.984 42.12 re W* n BT /TT1 12 Tf 88.464 692.02 Td ( )Tj ET Q q 59.4 660.7 33.984 42.12 re W* n BT 100.82 692.02 Td ( )Tj ET EMC Q Q /P <</MCID 8 >>BDC q 93.39 660.7 452.13 42.114 re W* n BT 99.144 691.66 Td [(The)5 ( )-409 (va)-5 (ria)5 (ble )]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 172.34 691.66 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 178.34 691.66 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 186.29 691.66 Td [<6861>4 <7320>-420 <61>4 <20>-419 <7374616E6461>5 <726420>-406 <6E6F>-9 <726D61>5 <6C20>-411 <64697374>-4 <726962757469>-2 <6F6E2E20>-419 <49>13 <6620>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 396.43 691.66 Td <0732>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 404.11 691.66 Td <123A>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 409.15 691.66 Td <0372>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 419.14 691.66 Td <0D51>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 431.5 691.66 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 440.86 691.66 Td <0D51>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 453.1 691.66 Td <0373>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 459.82 691.66 Td <123B>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 466.42 691.66 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 470.74 691.66 Td <0D4C>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 482.98 691.66 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 485.62 691.66 Td <0372>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 492.34 691.66 Td <01E4>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf -0.048 Tc 494.86 691.66 Td <03750376>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 508.06 691.66 Td [<2C20>-409 <7468656E>-7 <20>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 542.76 691.66 Td <202020>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 551.76 691.66 Td <20202020>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 99.144 677.38 Td <0732>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 106.82 677.38 Td <123A>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 111.86 677.38 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 8.52 Tf 118.22 681.82 Td <0B36>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 125.3 677.38 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 129.62 677.38 Td <0D50>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 141.98 677.38 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 144.62 677.38 Td <0373>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 151.22 677.38 Td <123B>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 156.26 677.38 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 159.26 677.38 Td [<69732065717561>5 <6C2074>-3 <6F2020>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 214.61 677.38 Td [<28757020746F2074776F206465>-4 <63>4 <696D>-3 <61>4 <6C20706C>-3 <61>4 <63>4 <65>4 <7329>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 341.83 677.38 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 344.83 677.38 Td <5F5F5F5F5F5F5F5F5F>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 398.95 677.38 Td <20>Tj ET EMC Q /P <</MCID 9 >>BDC q 93.39 660.69 452.13 42.12 re W* n BT 99.144 663.7 Td <20>Tj ET EMC Q BT /P <</MCID 10 >>BDC 54 642.7 Td <20>Tj EMC /P <</MCID 11 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 569.85 33.99 56.04 re W* n /P <</MCID 12 >>BDC q 59.4 569.86 33.984 56.04 re W* n BT 64.824 615.1 Td <512E3233>Tj ET Q q 59.4 569.86 33.984 56.04 re W* n BT /TT1 12 Tf 88.464 615.1 Td ( )Tj ET Q q 59.4 569.86 33.984 56.04 re W* n BT 100.82 615.1 Td ( )Tj ET EMC Q Q /P <</MCID 13 >>BDC q 93.39 569.86 452.13 56.034 re W* n BT 99.144 615.1 Td [(The)5 ( )-19 (a)4 (bs)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 136.94 615.1 Td [(orba)7 (n)-9 (c)4 (e)4 ( )-19 (of )-16 (a)4 ( )-19 (solut)-4 (ion )-21 (of )-16 (tr)-8 (y)30 (ptophan )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 310.03 615.1 Td [(me)-7 (a)4 (su)-10 (re)7 (d )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 359.35 615.1 Td [(a)4 (t )-21 (280 )-19 (nm )-21 (in )-21 (a)4 ( )-19 (c)4 (uve)4 (tt)6 (e)4 ( )-19 (of )-16 (2.0 )-19 (c)4 (m )-21 (pa)4 (th)8 ( )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 99.144 600.34 Td [(leng)12 (th )-141 (is )-142 (0.56)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 167.42 600.34 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 172.1 600.34 Td [(a)4 (t )-141 (pH )-137 (7)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 210.77 600.34 Td [(. )-129 (The)5 ( )-139 (mol)-3 (a)4 (r )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 274.25 600.34 Td [(e)4 (x)-9 (ti)-3 (nc)4 (ti)-3 (on)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 322.27 600.34 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 326.95 600.34 Td [(c)4 (oe)4 (ff)6 (icie)4 (nt )-141 (\()]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT /C0_0 12 Tf 386.83 600.34 Td <0048>Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 391.99 600.34 Td [<2920>-136 <666F72>6 <20>-139 <7472>-18 <79>20 <70746F7068>-11 <61>4 <6E20>-139 <61>4 <7420>-141 <32383020>-139 <6E6D20>-131 <69>8 <73>9 <20>]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 542.76 600.34 Td <202020202020>Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 99.144 586.66 Td [<3536303020>40 <4D>]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 136.34 591.22 Td (-)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 138.98 591.22 Td (1)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT -0.048 Tc 143.06 586.66 Td (cm)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 157.7 591.22 Td (-)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 160.34 591.22 Td (1)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 164.42 591.22 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 166.22 586.66 Td [(a)4 (t )38 (pH )42 (7)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 200.57 586.66 Td [(. )40 (The)5 ( )40 (c)4 (onc)-5 (e)4 (ntra)5 (ti)-3 (on )40 (o)-9 (f )43 (tr)-18 (y)20 (pto)-11 (pha)4 (n )40 (\(in )41 (\265)-3 (M\) )42 (in )38 (th)-11 (e)4 ( )40 (solut)-4 (ion )38 ( )40 (is )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 485.74 586.66 Td (__)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 497.74 586.66 Td (_______)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 539.76 586.66 Td ( )Tj ET EMC Q /P <</MCID 14 >>BDC q 93.39 569.85 452.13 56.04 re W* n BT 99.144 572.86 Td ( )Tj ET EMC Q BT /P <</MCID 15 >>BDC 54 551.83 Td ( )Tj EMC /P <</MCID 16 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 493.63 33.99 41.4 re W* n /P <</MCID 17 >>BDC q 59.4 493.63 33.984 41.4 re W* n BT 64.824 524.23 Td (Q.24)Tj ET Q q 59.4 493.63 33.984 41.4 re W* n BT /TT1 12 Tf 88.464 524.23 Td ( )Tj ET Q q 59.4 493.63 33.984 41.4 re W* n BT 100.82 524.23 Td ( )Tj ET EMC Q Q /P <</MCID 18 >>BDC q 93.39 493.63 452.13 41.397 re W* n BT 99.144 524.23 Td [(A )-17 (sing)7 (le)-7 ( )-19 (stem )-20 (c)4 (e)4 (ll)-3 ( )-19 (und)-9 (e)4 (r)-6 (g)10 (oe)4 (s)-10 ( )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 242.09 524.23 Td (10)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 254.09 524.23 Td ( )Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 257.33 524.23 Td [(a)4 (s)-20 (y)20 (mm)-3 (e)4 (tric)-6 ( )-19 (c)4 (e)4 (ll)-3 ( )-29 (divi)-3 (s)]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 360.67 524.23 Td [(ions. )-22 (The)5 ( )-19 (number)5 ( )-19 (of)-6 ( )-19 (stem )-20 (c)4 (e)4 (ll)]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 505.18 524.23 Td (s)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 509.86 524.23 Td ( )Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 513.1 524.23 Td [(a)4 (t )-21 (the)-7 ( )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 99.144 510.43 Td [(e)4 (nd is )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 130.46 510.43 Td (_________)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 184.49 510.43 Td ( )Tj ET EMC Q /P <</MCID 19 >>BDC q 93.39 493.63 452.13 41.4 re W* n BT 99.144 496.63 Td ( )Tj ET EMC Q BT /P <</MCID 20 >>BDC 54 475.63 Td ( )Tj EMC /P <</MCID 21 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 403.63 33.99 55.2 re W* n /P <</MCID 22 >>BDC q 59.4 403.63 33.984 55.2 re W* n BT 64.824 448.03 Td (Q.25)Tj ET Q q 59.4 403.63 33.984 55.2 re W* n BT /TT1 12 Tf 88.464 448.03 Td ( )Tj ET Q q 59.4 403.63 33.984 55.2 re W* n BT 100.82 448.03 Td ( )Tj ET EMC Q Q /P <</MCID 23 >>BDC q 93.39 403.63 452.13 55.197 re W* n BT 99.144 448.03 Td [(Ge)6 (nomi)-3 (c)4 ( )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT -0.024 Tc 148.7 448.03 Td (DNA )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 180.29 448.03 Td [(isol)-4 (a)4 (ted)-7 ( )-219 (fr)6 (om )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT -0.048 Tc 252.29 448.03 Td (a )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 263.21 448.03 Td [(ba)4 (c)4 (ter)5 (ium)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 311.11 448.03 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 316.75 448.03 Td [(wa)6 (s)-10 ( )-219 (dig)8 (e)4 (sted )-218 (with )-221 (a)4 ( )-219 (re)7 (strict)-9 (ion )-221 (e)4 (nz)-15 (y)30 (m)-11 (e)4 ( )-219 (that )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 99.144 434.23 Td [(re)7 (c)4 (o)-9 (g)10 (niz)-7 (e)4 (s a)3 ( 6)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 167.66 434.23 Td (-)Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 171.62 434.23 Td [(ba)4 (se)3 ( pa)4 (ir)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 214.49 434.23 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 217.49 434.23 Td [(\()-6 (bp\))]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 237.53 434.23 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 240.53 434.23 Td [(se)3 (que)4 (nc)4 (e)4 (. Assumi)-3 (n)-9 (g)10 ( ra)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 351.31 434.23 Td [(ndom di)-3 (stribut)-3 (ion of ba)15 (se)3 (s, the a)5 (ve)4 (ra)-2 (g)10 (e)-5 ( )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 99.144 420.43 Td [(leng)12 (th \(in bp\) o)-7 (f the)5 ( fr)-3 (a)-5 (gments g)9 (e)4 (n)-9 (e)4 (ra)7 (t)-11 (e)4 (d is )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 309.79 420.43 Td (_________)Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 363.79 420.43 Td ( )Tj ET EMC Q /P <</MCID 24 >>BDC q 93.39 403.63 452.13 55.2 re W* n BT 99.144 406.63 Td ( )Tj ET EMC Q BT /P <</MCID 25 >>BDC 54 385.63 Td ( )Tj EMC /P <</MCID 26 >>BDC /TT0 11.04 Tf 0 -12.98 Td ( )Tj 144.05 0 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (5)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q BT /P <</MCID 0 >>BDC /TT1 12.96 Tf -0.0029 Tc 54 775.56 Td (Q. )Tj 0 Tc 16.584 0 Td (26 )Tj /C2_0 12.96 Tf <00B1>Tj /TT1 12.96 Tf [( Q.)-8.002 ( )-0.725 (55 carry)-10 ( tw)-8.997 (o )-8.002 (m)8.997 (arks e)-8.997 (ach.)-14.9 ( )]TJ EMC /P <</MCID 1 >>BDC /TT0 12 Tf -16.584 -25.7 Td ( )Tj EMC ET q 59.4 638.85 33.99 108 re W* n /P <</MCID 2 >>BDC q 59.4 638.86 33.984 108 re W* n BT 64.824 736.06 Td (Q.26)Tj ET Q q 59.4 638.86 33.984 108 re W* n BT /TT2 12 Tf 88.464 736.06 Td ( )Tj ET Q q 59.4 638.86 33.984 108 re W* n BT 100.82 736.06 Td ( )Tj ET EMC Q Q q 93.39 705.45 452.13 41.4 re W* n /P <</MCID 3 >>BDC q 93.384 705.46 452.14 41.4 re W* n BT 99.144 736.06 Td [(I)13 (n )30 (le)-7 (g)10 (umi)-3 (nous )29 (plants, )29 (b)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 210.65 736.06 Td [(ot)8 (h )30 (the )32 (rhiz)-4 (obiu)8 (m )28 (g)10 (e)4 (ne)4 (s )29 (a)4 (n)-9 (d )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 347.59 736.06 Td (the )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 364.87 736.06 Td [(plant )30 (g)10 (e)4 (ne)4 (s )29 (influe)3 (nc)-5 (e)4 ( )30 (nodulation )28 (a)4 (nd)10 ( )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 99.144 722.26 Td [(nit)-3 (rog)13 (e)4 (n )-59 (fix)-8 (a)4 (ti)-3 (on. )-49 (W)-5 (h)10 (ich )-47 (o)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 228.29 722.26 Td [(ne)4 ( )-49 (of )-46 (the )-47 (followin)-10 (g)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 321.67 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 325.27 722.26 Td [(fun)-6 (c)4 (ti)-3 (ons)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 370.03 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 373.63 722.26 Td (is )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT /TT1 12 Tf 385.27 722.26 Td (NOT)Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 411.31 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 414.91 722.26 Td [(e)4 (nc)4 (ode)4 (d)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 454.78 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 458.38 722.26 Td [(b)-9 (y)20 ( )-49 (the )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 492.1 722.26 Td (host)Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 512.14 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 515.74 722.26 Td (plant )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 99.144 708.46 Td [(g)10 (e)4 (n)-9 (e)4 (s?)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 131.78 708.46 Td ( )Tj ET EMC Q Q q 93.39 684.45 452.13 13.8 re W* n /P <</MCID 4 >>BDC q 93.384 684.46 452.14 13.8 re W* n BT 98.784 687.46 Td [(\(A)5 (\) Produc)6 (ti)-3 (on of)3 ( induc)-7 (e)-5 (rs tha)4 (t m)-3 (odif)-8 (y)20 ( rhiz)-4 (obial c)-5 (e)4 (ll)-3 ( wa)6 (ll)]TJ ET Q q 93.384 684.46 452.14 13.8 re W* n BT 376.15 687.46 Td ( )Tj ET EMC Q Q q 93.39 670.65 452.13 13.8 re W* n /P <</MCID 5 >>BDC q 93.384 670.66 452.14 13.8 re W* n BT 98.784 673.66 Td [(\(B)10 (\) )]TJ ET Q q 93.384 670.66 452.14 13.8 re W* n BT 117.62 673.66 Td [(P)-3 (rodu)-6 (c)4 (ti)-3 (on of)3 ( fla)5 (von)-9 (oid i)-3 (nduc)4 (e)4 (rs)]TJ ET Q q 93.384 670.66 452.14 13.8 re W* n BT 276.17 673.66 Td ( )Tj ET EMC Q Q q 93.39 656.85 452.13 13.8 re W* n /P <</MCID 6 >>BDC q 93.384 656.86 452.14 13.8 re W* n BT 98.784 659.86 Td [(\(C\) E)4 (stablis)-3 (hment of)3 ( c)4 (on)-9 (tac)6 (t betwe)-3 (e)4 (n ba)4 (c)4 (te)-7 (ria)5 ( a)4 (nd)-9 ( leg)12 (ume)]TJ ET Q q 93.384 656.86 452.14 13.8 re W* n BT 379.03 659.86 Td ( )Tj ET EMC Q Q q 93.39 638.85 452.13 18 re W* n /P <</MCID 7 >>BDC q 93.384 638.86 452.14 18 re W* n BT 98.784 646.06 Td [(\(D)5 (\) Root hair)3 ( c)4 (u)-9 (rling)]TJ ET Q q 93.384 638.86 452.14 18 re W* n BT 200.45 646.06 Td ( )Tj ET EMC Q Q BT /P <</MCID 8 >>BDC 54 628.06 Td ( )Tj EMC /P <</MCID 9 >>BDC 0 -13.68 Td ( )Tj EMC ET q 59.4 445.88 33.99 165.5 re W* n /P <</MCID 10 >>BDC q 59.4 445.87 33.984 165.5 re W* n BT 64.824 600.58 Td (Q.27)Tj ET Q q 59.4 445.87 33.984 165.5 re W* n BT /TT2 12 Tf 88.464 600.58 Td ( )Tj ET Q q 59.4 445.87 33.984 165.5 re W* n BT 100.82 600.58 Td ( )Tj ET EMC Q Q /P <</MCID 11 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 600.58 Td [(W)-5 (hich of)5 ( the f)5 (oll)-3 (owing)10 ( c)-5 (y)20 (t)-11 (okines a)-4 (re)7 ( e)4 (ndo)-9 (ge)4 (nous )-10 (p)-9 (y)20 (ro)-6 (ge)4 (ns?)]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 390.79 600.58 Td ( )Tj ET EMC Q /P <</MCID 12 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 586.78 Td ( )Tj ET EMC Q /P <</MCID 13 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 572.02 Td [(P)-3 (. Tumor ne)6 (c)4 (rosis fa)-3 (c)4 (tor)]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 217.73 572.02 Td (-)Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT /C0_0 12 Tf 221.81 572.02 Td <0044>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 229.37 572.02 Td <20>Tj ET EMC Q /P <</MCID 14 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 558.19 Td [<512E20>-7 <49>13 <6E746572>5 <6C65756B696E>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 166.34 558.19 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 170.3 558.19 Td <31>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 176.42 558.19 Td <20>Tj ET EMC Q /P <</MCID 15 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 544.39 Td [<52>-2 <2E20>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 113.18 544.39 Td [<5472>4 <61>4 <6E73666F72>5 <6D69>-3 <6E>-9 <67>10 <20>-9 <67>10 <726F77>5 <746820>-11 <6661>7 <63>4 <746F72>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 247.01 544.39 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT /C2_1 12 Tf 250.97 544.39 Td <0215>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 257.21 544.39 Td <20>Tj ET EMC Q /P <</MCID 16 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 530.59 Td [<53>-3 <2E20>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 111.86 530.59 Td <20>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 114.98 530.59 Td [<49>23 <6E746572>5 <6C>-11 <65>4 <756B696E>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 167.42 530.59 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 171.38 530.59 Td <31>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 177.38 530.59 Td <30>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 183.41 530.59 Td <20>Tj ET EMC Q /P <</MCID 17 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 516.79 Td <20>Tj ET EMC Q q 93.39 492.79 452.13 13.8 re W* n /P <</MCID 18 >>BDC q 93.384 492.79 452.14 13.8 re W* n BT 98.784 495.79 Td [<2841>5 <29>]TJ ET Q q 93.384 492.79 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 495.79 Td ( )Tj ET Q q 93.384 492.79 452.14 13.8 re W* n BT 116.78 495.79 Td ( )Tj ET Q q 93.384 492.79 452.14 13.8 re W* n BT 119.78 495.79 Td [(P)-3 ( a)4 (nd Q onl)-9 (y)]TJ ET Q q 93.384 492.79 452.14 13.8 re W* n BT 182.81 495.79 Td ( )Tj ET EMC Q Q q 93.39 478.99 452.13 13.8 re W* n /P <</MCID 19 >>BDC q 93.384 478.99 452.14 13.8 re W* n BT 98.784 481.99 Td [(\(B)10 (\))]TJ ET Q q 93.384 478.99 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 481.99 Td ( )Tj ET Q q 93.384 478.99 452.14 13.8 re W* n BT 116.78 481.99 Td ( )Tj ET Q q 93.384 478.99 452.14 13.8 re W* n BT 119.78 481.99 Td [(P)-3 ( a)4 (nd R)-2 ( onl)-11 (y)]TJ ET Q q 93.384 478.99 452.14 13.8 re W* n BT 182.21 481.99 Td ( )Tj ET EMC Q Q q 93.39 465.19 452.13 13.8 re W* n /P <</MCID 20 >>BDC q 93.384 465.19 452.14 13.8 re W* n BT 98.784 468.19 Td (\(C\))Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 468.19 Td ( )Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT 116.78 468.19 Td ( )Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT 119.78 468.19 Td [(R)-2 ( a)4 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 465.19 452.14 13.8 re W* n BT 182.21 468.19 Td ( )Tj ET EMC Q Q q 93.39 445.87 452.13 19.32 re W* n /P <</MCID 21 >>BDC q 93.384 445.87 452.14 19.32 re W* n BT 98.784 454.39 Td [(\(D)5 (\))]TJ ET Q q 93.384 445.87 452.14 19.32 re W* n BT /TT2 12 Tf 115.46 454.39 Td ( )Tj ET Q q 93.384 445.87 452.14 19.32 re W* n BT 116.78 454.39 Td ( )Tj ET Q q 93.384 445.87 452.14 19.32 re W* n BT 119.78 454.39 Td [(Q a)6 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 445.87 452.14 19.32 re W* n BT 182.81 454.39 Td ( )Tj ET EMC Q Q BT /P <</MCID 22 >>BDC 54 435.07 Td ( )Tj EMC /P <</MCID 23 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 258.88 33.99 159.39 re W* n /P <</MCID 24 >>BDC q 59.4 258.89 33.984 159.38 re W* n BT 64.824 407.47 Td (Q.28)Tj ET Q q 59.4 258.89 33.984 159.38 re W* n BT /TT2 12 Tf 88.464 407.47 Td ( )Tj ET Q q 59.4 258.89 33.984 159.38 re W* n BT 100.82 407.47 Td ( )Tj ET EMC Q Q /P <</MCID 25 >>BDC q 93.39 294.05 452.13 124.22 re W* n BT 99.144 407.47 Td [(Ma)3 (tch the)4 ( c)4 (lasse)4 (s o)-10 (f RN)-7 (A molec)6 (ul)]TJ ET Q q 93.39 294.05 452.13 124.22 re W* n BT 266.81 407.47 Td [(e)4 (s in Group )-7 (I)13 ( )-9 (with t)-3 (he)4 (ir f)4 (unc)4 (ti)-3 (ons i)-2 (n Gr)-4 (oup )-9 (II)16 (.)]TJ ET Q q 93.39 294.05 452.13 124.22 re W* n BT 486.94 407.47 Td ( )Tj ET EMC Q /P <</MCID 26 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 393.67 Td ( )Tj ET EMC Q /P <</MCID 27 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 99.144 379.61 Td [(G)8 (r)4 (ou)-3 (p)-3 ( I)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 140.78 379.61 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 171.14 379.61 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 201.17 379.61 Td [(G)8 (r)4 (ou)-3 (p)-3 ( II)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 247.49 379.61 Td ( )Tj ET EMC Q /P <</MCID 28 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 366.05 Td [(P)-3 (. snoR)-3 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 153.86 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 366.05 Td (1)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 366.05 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 366.05 Td [(P)-3 (rote)5 (c)4 (ts ger)4 (ml)-3 (ine f)5 (rom tra)6 (nspos)-11 (a)4 (ble e)6 (lem)-9 (e)4 (nts )]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 435.46 366.05 Td ( )Tj ET EMC Q /P <</MCID 29 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 352.25 Td [(Q. piR)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 148.46 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 352.25 Td (2)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 352.25 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 352.25 Td [(B)7 (locks tra)6 (nslati)-12 (on of)3 ( se)3 (lec)6 (ted mR)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 392.47 352.25 Td ( )Tj ET EMC Q /P <</MCID 30 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 338.45 Td [(R)-2 (. mi)-3 (R)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 151.1 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 338.45 Td (3)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 338.45 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 338.45 Td [(Te)5 (mpl)-3 (a)4 (te f)5 (or te)5 (l)-11 (omer)5 (e)4 ( e)4 (lon)-11 (g)10 (a)4 (ti)-3 (o)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 367.99 338.45 Td (n)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 374.11 338.45 Td ( )Tj ET EMC Q /P <</MCID 31 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 324.65 Td [(S)-3 (. snR)-3 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 147.86 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 324.65 Td (4.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 324.65 Td [(Modi)-2 (fic)5 (a)4 (ti)-3 (on a)4 (n)-9 (d pro)3 (c)4 (e)4 (ssi)-3 (n)-9 (g)10 ( of r)6 (R)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 395.83 324.65 Td ( )Tj ET EMC Q /P <</MCID 32 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 171.14 310.85 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 310.85 Td (5)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 310.85 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 310.85 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 310.85 Td [(S)-3 (pli)-3 (c)4 (ing)8 ( of RN)-7 (A tra)7 (nsc)3 (ripts)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 347.59 310.85 Td ( )Tj ET EMC Q /P <</MCID 33 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 171.14 297.05 Td ( )Tj ET EMC Q q 93.39 272.8 212.57 14.04 re W* n /P <</MCID 34 >>BDC q 93.384 272.81 212.57 14.04 re W* n BT 98.784 276.05 Td [(\(A)5 (\) P)]TJ ET Q q 93.384 272.81 212.57 14.04 re W* n BT 125.06 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 129.02 276.05 Td (3)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 135.02 276.05 Td (, Q)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 149.66 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 153.62 276.05 Td (5)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 159.62 276.05 Td (, R)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 173.66 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 177.62 276.05 Td (2)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 183.65 276.05 Td (, S)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 196.37 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 200.33 276.05 Td (4)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 206.45 276.05 Td ( )Tj ET EMC Q Q q 305.96 272.8 239.57 14.04 re W* n /P <</MCID 35 >>BDC q 305.95 272.81 239.57 14.04 re W* n BT 311.35 276.05 Td [(\(B)10 (\) P)]TJ ET Q q 305.95 272.81 239.57 14.04 re W* n BT 336.91 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 340.87 276.05 Td (1)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 346.87 276.05 Td (, Q)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 361.63 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 365.59 276.05 Td (3)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 371.59 276.05 Td (, R)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 385.63 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 389.59 276.05 Td (2)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 395.59 276.05 Td (, S)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 408.31 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 412.27 276.05 Td (5)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 418.39 276.05 Td ( )Tj ET EMC Q Q q 93.39 258.88 212.57 13.92 re W* n /P <</MCID 36 >>BDC q 93.384 258.89 212.57 13.92 re W* n BT 98.784 262.01 Td (\(C\) P)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 124.46 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 128.42 262.01 Td (1)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 134.42 262.01 Td (, Q)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 149.06 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 153.02 262.01 Td (4)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 159.02 262.01 Td (, R)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 173.06 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 177.02 262.01 Td (5)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 183.05 262.01 Td (, S)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 195.77 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 199.73 262.01 Td (2)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 205.85 262.01 Td ( )Tj ET EMC Q Q q 305.96 258.88 239.57 13.92 re W* n /P <</MCID 37 >>BDC q 305.95 258.89 239.57 13.92 re W* n BT 311.35 262.01 Td (\()Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 315.31 262.01 Td [(D\))5 ( P)]TJ ET Q q 305.95 258.89 239.57 13.92 re W* n BT 337.63 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 341.59 262.01 Td (4)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 347.59 262.01 Td (, Q)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 362.23 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 366.19 262.01 Td (1, R)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 386.23 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 390.19 262.01 Td (2)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 396.19 262.01 Td (, S)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 408.91 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 412.87 262.01 Td (5)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 419.02 262.01 Td ( )Tj ET EMC Q Q BT /P <</MCID 38 >>BDC 54 248.09 Td ( )Tj EMC /P <</MCID 39 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 86.07 33.99 145.22 re W* n /P <</MCID 40 >>BDC q 59.4 86.064 33.984 145.22 re W* n BT 64.824 220.49 Td (Q.29)Tj ET Q q 59.4 86.064 33.984 145.22 re W* n BT /TT2 12 Tf 88.464 220.49 Td ( )Tj ET Q q 59.4 86.064 33.984 145.22 re W* n BT 100.82 220.49 Td ( )Tj ET EMC Q Q /P <</MCID 41 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 220.49 Td [(De)6 (ter)5 (mi)-3 (ne)4 ( the )-7 (c)4 (orr)-3 (e)4 (c)4 (tnes)-8 (s or othe)4 (rw)5 (ise of)4 ( th)-11 (e)4 ( following)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 367.27 220.49 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 370.27 220.49 Td (A)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 378.91 220.49 Td [(sse)-7 (rtion [)-7 (a)4 (])-6 ( a)4 (nd the Rea)7 (son [)-7 (r])]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 524.14 220.49 Td ( )Tj ET EMC Q /P <</MCID 42 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 206.69 Td ( )Tj ET EMC Q /P <</MCID 43 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 192.86 Td [(Asse)4 (rtion:)-2 ( )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT /TT3 12 Tf 151.7 192.86 Td [(Ab )-18 (ini)-3 (ti)-3 (o)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 193.73 192.86 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 196.97 192.86 Td [(g)10 (e)4 (ne)-5 ( )-19 (finding)9 ( )-19 (a)4 (l)-11 (g)10 (orithm)-2 (s )-20 (that)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 333.19 192.86 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 336.43 192.86 Td [(pre)7 (dict )-19 (prote)5 (in )-21 (c)4 (odin)-11 (g)10 ( )-29 (g)10 (e)-5 (ne)4 (s )-20 (in )-21 (e)4 (uka)4 (r)-16 (y)20 (oti)-3 (c)4 ( )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 99.144 179.06 Td [(g)10 (e)4 (nom)-11 (e)4 (s )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 144.74 179.06 Td [(a)4 (r)-6 (e)4 ( not complet)-9 (e)4 (l)-11 (y)20 ( )-9 (a)4 (c)4 (c)4 (u)-9 (ra)7 (te)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 277.01 179.06 Td (.)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 280.13 179.06 Td ( )Tj ET EMC Q /P <</MCID 44 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 165.26 Td ( )Tj ET EMC Q /P <</MCID 45 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 151.46 Td [(R)-2 (e)4 (a)4 (son:)-2 ( Euka)5 (r)-16 (y)20 (oti)-3 (c)4 ( spl)-2 (ic)-7 (e)4 ( sit)-4 (e)4 (s a)3 (re)7 ( dif)-8 (fic)5 (ult)-3 ( to pre)-4 (dict)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 356.83 151.46 Td (.)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 359.83 151.46 Td ( )Tj ET EMC Q q 93.39 127.47 452.13 13.8 re W* n /P <</MCID 46 >>BDC q 93.384 127.46 452.14 13.8 re W* n BT 98.784 130.46 Td [(\(A)5 (\))]TJ ET Q q 93.384 127.46 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 130.46 Td ( )Tj ET Q q 93.384 127.46 452.14 13.8 re W* n BT 116.78 130.46 Td ( )Tj ET Q q 93.384 127.46 452.14 13.8 re W* n BT 119.78 130.46 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( fa)7 (lse)]TJ ET Q q 93.384 127.46 452.14 13.8 re W* n BT 238.13 130.46 Td ( )Tj ET EMC Q Q q 93.39 113.67 452.13 13.8 re W* n /P <</MCID 47 >>BDC q 93.384 113.66 452.14 13.8 re W* n BT 98.784 116.66 Td [(\(B)10 (\))]TJ ET Q q 93.384 113.66 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 116.66 Td ( )Tj ET Q q 93.384 113.66 452.14 13.8 re W* n BT 116.78 116.66 Td ( )Tj ET Q q 93.384 113.66 452.14 13.8 re W* n BT 119.78 116.66 Td [([)-6 (a)4 (])-6 ( is )7 (true)5 ( but [)-8 (r])-3 ( is fa)4 (lse)]TJ ET Q q 93.384 113.66 452.14 13.8 re W* n BT 235.73 116.66 Td ( )Tj ET EMC Q Q q 93.39 99.87 452.13 13.8 re W* n /P <</MCID 48 >>BDC q 93.384 99.864 452.14 13.8 re W* n BT 98.784 102.86 Td (\(C\))Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 102.86 Td ( )Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT 116.78 102.86 Td ( )Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT 119.78 102.86 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is t)-4 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t re)-4 (a)4 (s)-10 (on fo)3 (r [)-3 (a)4 (])]TJ ET Q q 93.384 99.864 452.14 13.8 re W* n BT 402.07 102.86 Td ( )Tj ET EMC Q Q q 93.39 86.07 452.13 13.8 re W* n /P <</MCID 49 >>BDC q 93.384 86.064 452.14 13.8 re W* n BT 98.784 89.064 Td [(\(D)5 (\))]TJ ET Q q 93.384 86.064 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 89.064 Td ( )Tj ET Q q 93.384 86.064 452.14 13.8 re W* n BT 116.78 89.064 Td ( )Tj ET Q q 93.384 86.064 452.14 13.8 re W* n BT 119.78 89.064 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( but [)-8 (r])-3 ( )10 (is not)-4 ( the c)6 (orr)6 (e)4 (c)4 (t r)-8 (e)4 (a)4 (son for)5 ( [)-6 (a)4 (])]TJ ET Q q 93.384 86.064 452.14 13.8 re W* n BT 418.27 89.064 Td ( )Tj ET EMC Q Q BT /P <</MCID 50 >>BDC 54 75.264 Td ( )Tj EMC /P <</MCID 51 >>BDC 0 -13.8 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (6)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 734.01 33.99 53.67 re W* n /P <</MCID 0 >>BDC q 59.4 734.02 33.984 53.664 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.30)Tj ET Q q 59.4 734.02 33.984 53.664 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 734.02 33.984 53.664 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q q 93.39 760.08 452.13 27.6 re W* n /P <</MCID 1 >>BDC q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(W)-5 (hich )-37 (one)4 ( )-39 (of )-36 (the )-37 (followi)-10 (ng)10 ( )-39 (a)4 (mi)-3 (no )-49 (a)4 (c)4 (ids )-42 (is )-42 (c)4 (a)4 (tal)-19 (y)20 (z)-15 (e)4 (d )-39 (b)-9 (y)20 ( )-49 (a)4 (c)4 (ti)-3 (va)4 (ted)-7 ( )-39 (mac)6 (roph)-6 (a)4 (ge)4 (s )-40 (to )-41 (prod)]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 523.06 776.88 Td [(uc)-5 (e)4 ( )]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 99.144 763.08 Td [(re)7 (a)4 (c)4 (ti)-3 (ve)4 ( nit)-3 (ro)-6 (ge)4 (n spe)3 (c)4 (i)-11 (e)4 (s)-10 (?)]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 223.13 763.08 Td ( )Tj ET EMC Q Q q 93.39 734.01 106.22 18.87 re W* n /P <</MCID 2 >>BDC q 93.384 734.02 106.22 18.864 re W* n BT /TT0 12 Tf 98.784 742.06 Td [(\(A)5 (\) A)5 (r)-6 (g)10 (ini)-3 (ne)]TJ ET Q q 93.384 734.02 106.22 18.864 re W* n BT /TT0 12 Tf 161.06 742.06 Td ( )Tj ET EMC Q Q q 199.61 734.01 106.35 18.87 re W* n /P <</MCID 3 >>BDC q 199.61 734.02 106.34 18.864 re W* n BT /TT0 12 Tf 205.01 742.06 Td [(\(B)10 (\) )-6 (Aspa)5 (r)-6 (a)-5 (g)10 (ine)]TJ ET Q q 199.61 734.02 106.34 18.864 re W* n BT /TT0 12 Tf 278.69 742.06 Td ( )Tj ET EMC Q Q q 305.96 734.01 106.2 18.87 re W* n /P <</MCID 4 >>BDC q 305.95 734.02 106.2 18.864 re W* n BT /TT0 12 Tf 311.35 742.06 Td [(\(C\) C)-9 (y)20 (steine)]TJ ET Q q 305.95 734.02 106.2 18.864 re W* n BT /TT0 12 Tf 375.31 742.06 Td ( )Tj ET EMC Q Q q 412.16 734.01 133.36 18.87 re W* n /P <</MCID 5 >>BDC q 412.15 734.02 133.37 18.864 re W* n BT /TT0 12 Tf 417.55 742.06 Td [(\(D)5 (\) H)5 (ist)-4 (idi)-3 (ne)]TJ ET Q q 412.15 734.02 133.37 18.864 re W* n BT /TT0 12 Tf 484.3 742.06 Td ( )Tj ET EMC Q Q BT /P <</MCID 6 >>BDC /TT0 11.04 Tf 54 724.06 Td ( )Tj EMC /P <</MCID 7 >>BDC 0 -12.72 Td ( )Tj EMC ET q 59.4 562.4 33.99 146.3 re W* n /P <</MCID 8 >>BDC q 59.4 562.39 33.984 146.3 re W* n BT /TT0 12 Tf 64.824 697.9 Td (Q.31)Tj ET Q q 59.4 562.39 33.984 146.3 re W* n BT /TT1 12 Tf 88.464 697.9 Td ( )Tj ET Q q 59.4 562.39 33.984 146.3 re W* n BT /TT0 12 Tf 100.82 697.9 Td ( )Tj ET EMC Q Q /P <</MCID 9 >>BDC q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 99.144 697.9 Td [(De)6 (ter)5 (mi)-3 (ne)4 ( the )-7 (c)4 (orr)-3 (e)4 (c)4 (tnes)-8 (s or othe)4 (rw)5 (ise of)4 ( th)-11 (e)4 ( following)9 ( A)]TJ ET Q q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 378.91 697.9 Td [(sse)-7 (rtion [)-7 (a)4 (])-6 ( a)4 (nd the Rea)7 (son [)-7 (r])]TJ ET Q q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 524.14 697.9 Td ( )Tj ET EMC Q /P <</MCID 10 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 684.1 Td ( )Tj ET EMC Q /P <</MCID 11 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 670.3 Td [(Asse)4 (rtion)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 145.1 670.3 Td [(: )-21 (The)5 ( )-19 (a)4 (ssocia)4 (ti)-3 (on )-19 (c)4 (onst)-2 (a)4 (nt )-21 (in )-21 (wa)6 (ter)5 ( )-19 (for)6 ( )-19 (the )-17 (G)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 359.35 670.3 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 363.31 670.3 Td [(C)-2 ( )-19 (ba)4 (se)3 ( )-19 (pa)4 (ir )-18 (is )-22 (th)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 441.58 670.3 Td [(re)7 (e)4 ( )-19 (ti)-3 (mes )-18 (lowe)4 (r )-16 (than )]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 656.5 Td [(that f)3 (or the)5 ( A)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 163.34 656.5 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 167.3 656.5 Td [(T b)-8 (a)4 (se)3 ( )]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 202.01 656.5 Td [(pa)4 (i)-11 (r)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 220.85 656.5 Td (.)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 223.85 656.5 Td ( )Tj ET EMC Q /P <</MCID 12 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 642.7 Td ( )Tj ET EMC Q /P <</MCID 13 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 628.9 Td [(R)-2 (e)4 (a)4 (son)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 134.42 628.9 Td [(: The)3 (re)7 ( )-9 (a)4 (re)7 ( th)-11 (re)7 (e)4 ( )-9 (h)-9 (y)20 (dro)-6 (ge)4 (n bonds i)-2 (n the G)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 334.99 628.9 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 339.07 628.9 Td [(C)-2 ( ba)4 (se)3 ( pa)4 (ir a)5 (nd two in t)-3 (h)-9 (e)4 ( A)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 476.02 628.9 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 479.98 628.9 Td [(T ba)5 (s)-10 (e)4 ( pa)4 (ir)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 533.26 628.9 Td (.)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 536.38 628.9 Td ( )Tj ET EMC Q q 93.39 604.89 452.13 13.8 re W* n /P <</MCID 14 >>BDC q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 607.9 Td [(\(A)5 (\))]TJ ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT1 12 Tf 115.46 607.9 Td ( )Tj ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 607.9 Td ( )Tj ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 607.9 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is t)-4 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t re)-4 (a)4 (s)-10 (on fo)3 (r [)-3 (a)4 (])]TJ ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 402.07 607.9 Td ( )Tj ET EMC Q Q q 93.39 591.09 452.13 13.8 re W* n /P <</MCID 15 >>BDC q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 594.1 Td [(\(B)10 (\))]TJ ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 594.1 Td ( )Tj ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 594.1 Td ( )Tj ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 594.1 Td [([)-6 (a)4 (])-6 ( is fa)4 (lse but [)-7 (r)13 (])-6 ( is t)-4 (rue)]TJ ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 235.73 594.1 Td ( )Tj ET EMC Q Q q 93.39 577.29 452.13 13.8 re W* n /P <</MCID 16 >>BDC q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 580.3 Td (\(C\))Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 580.3 Td ( )Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 580.3 Td ( )Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 580.3 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)]TJ ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 186.89 580.3 Td [(r])-3 ( a)4 (re)7 ( fa)7 (lse)]TJ ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 238.13 580.3 Td ( )Tj ET EMC Q Q q 93.39 562.4 452.13 14.895 re W* n /P <</MCID 17 >>BDC q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 98.784 566.5 Td [(\(D)5 (\))]TJ ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT1 12 Tf 115.46 566.5 Td ( )Tj ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 116.78 566.5 Td ( )Tj ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 119.78 566.5 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is no)-2 (t t)-3 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t r)-8 (e)4 (a)4 (son for)5 ( [)-6 (a)4 (])]TJ ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 420.34 566.5 Td ( )Tj ET EMC Q Q BT /P <</MCID 18 >>BDC /TT0 12 Tf 54 551.59 Td ( )Tj EMC /P <</MCID 19 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 382.48 33.99 152.31 re W* n /P <</MCID 20 >>BDC q 59.4 382.49 33.984 152.3 re W* n BT 64.824 523.99 Td (Q.32)Tj ET Q q 59.4 382.49 33.984 152.3 re W* n BT /TT1 12 Tf 88.464 523.99 Td ( )Tj ET Q q 59.4 382.49 33.984 152.3 re W* n BT 100.82 523.99 Td ( )Tj ET EMC Q Q /P <</MCID 21 >>BDC q 93.39 422.6 452.13 112.2 re W* n BT 99.144 523.99 Td [(W)-5 (hich )12 (one)4 ( )10 (of )13 (the )12 (c)4 (ombi)-3 (na)4 (ti)-3 (ons )9 (of )13 (the )12 (following)9 ( )10 (st)-12 (a)4 (teme)4 (nts )7 (is )7 (true)5 ( )10 (a)4 (bout )8 (a)4 (nt)-11 (ibod)-11 (y)20 ( )10 (struc)4 (tur)-8 (e)14 (?)]TJ ET Q q 93.39 422.6 452.13 112.2 re W* n BT 539.76 523.99 Td ( )Tj ET EMC Q /P <</MCID 22 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 510.19 Td ( )Tj ET EMC Q /P <</MCID 23 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 496.39 Td [(P)-3 (. )-9 (L)21 (im)-3 (it)-3 (e)4 (d pro)3 (teol)-19 (y)30 (sis)-3 ( of )-6 (ra)7 (bbit)-3 ( )-9 (I)13 (gG w)4 (it)-3 (h the e)6 (nz)-25 (y)10 (me pe)6 (psin g)-2 (e)4 (ne)4 (r)-6 (a)4 (tes two )-8 (a)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 465.46 496.39 Td [(nti)-3 (g)10 (e)4 (n)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 495.46 496.39 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 499.42 496.39 Td [(bindi)-3 (ng)10 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 539.04 496.39 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 542.16 496.39 Td ( )Tj ET EMC Q /P <</MCID 24 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 482.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 114.14 482.59 Td [(re)-2 (g)10 (ions \(F)-3 (a)4 (b\) a)7 (nd )-9 (a)4 (n )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT -0.072 Tc 216.17 482.59 Td (Fc)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 228.05 482.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 231.05 482.59 Td [(f)-6 (ra)-2 (g)10 (ment)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 274.49 482.59 Td ( )Tj ET EMC Q /P <</MCID 25 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 468.79 Td [(Q. )-7 (L)21 (im)-3 (it)-3 (e)4 (d pro)3 (teol)-19 (y)20 (sis)-3 ( of)-6 ( ra)7 (bbit)-3 ( )-9 (I)13 (gG w)4 (it)-3 (h the e)6 (nz)-25 (y)10 (me pa)6 (pa)4 (in )-11 (g)10 (e)4 (n)-9 (e)4 (ra)7 (tes )-8 (a)4 ( sing)7 (le biva)4 (l)-11 (e)4 (nt )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 523.42 468.79 Td ( )Tj ET EMC Q /P <</MCID 26 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 454.03 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 114.14 454.03 Td [(a)4 (nti)-3 (g)10 (e)4 (n)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 149.42 454.03 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 153.38 454.03 Td [(bindi)-3 (ng)10 ( )-9 (re)-2 (g)10 (io)-11 (n F)6 (\(a)7 (b)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT /C0_0 12 Tf 248.69 454.03 Td <0063>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 251.69 454.03 Td <29>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT /TT0 8.04 Tf 255.65 453.07 Td [(2)-5.995 ( )-3.01 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 263.81 454.03 Td [(a)4 (nd pe)4 (pti)-3 (de)4 ( fr)-3 (a)-5 (g)10 (ments)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 370.51 454.03 Td ( )Tj ET EMC Q /P <</MCID 27 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 440.35 Td [(R)-2 (. The)5 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT -0.072 Tc 134.78 440.35 Td (Fc)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 146.66 440.35 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 149.78 440.35 Td [(fr)6 (a)-5 (g)10 (ment of)3 ( )-19 (I)13 (g)-9 (G c)6 (a)4 (n se)3 (lf)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 267.77 440.35 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 271.73 440.35 Td [(a)4 (ssocia)4 (t)-11 (e)4 ( a)4 (nd )-9 (c)4 (r)-16 (y)20 (stalli)-4 (z)-5 (e)4 ( int)-3 (o )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 412.51 440.35 Td [(a)4 ( latti)-3 (c)4 (e)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 450.1 440.35 Td ( )Tj ET EMC Q /P <</MCID 28 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 425.59 Td [(S)-3 (. The)5 ( F)6 (\(a)7 (b)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT /C0_0 12 Tf 155.3 425.59 Td <0063>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 158.3 425.59 Td <29>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT /TT0 8.04 Tf 0.06 Tc 162.26 424.63 Td (2 )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 168.38 425.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 171.38 425.59 Td [(fr)6 (a)-5 (g)10 (m)-11 (e)4 (nt of )-8 (I)13 (gG is c)3 (ompos)-2 (e)4 (d of b)3 (o)-9 (th l)-3 (ig)8 (ht and he)6 (a)4 (v)-19 (y)20 ( )-9 (c)4 (ha)4 (in)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 455.26 425.59 Td (s)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 460.06 425.59 Td ( )Tj ET EMC Q q 93.39 401.35 212.57 14.04 re W* n /P <</MCID 29 >>BDC q 93.384 401.35 212.57 14.04 re W* n BT 98.784 404.59 Td [(\(A)5 (\) P an)3 (d Q onl)-19 (y)]TJ ET Q q 93.384 401.35 212.57 14.04 re W* n BT 181.49 404.59 Td ( )Tj ET EMC Q Q q 305.96 401.35 239.57 14.04 re W* n /P <</MCID 30 >>BDC q 305.95 401.35 239.57 14.04 re W* n BT 311.35 404.59 Td [(\(B)10 (\) P an)3 (d R)-2 ( onl)-21 (y)]TJ ET Q q 305.95 401.35 239.57 14.04 re W* n BT 392.71 404.59 Td ( )Tj ET EMC Q Q q 93.39 382.48 212.57 18.87 re W* n /P <</MCID 31 >>BDC q 93.384 382.49 212.57 18.864 re W* n BT 98.784 390.55 Td [(\(C\) R a)4 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 382.49 212.57 18.864 re W* n BT 180.17 390.55 Td ( )Tj ET EMC Q Q q 305.96 382.48 239.57 18.87 re W* n /P <</MCID 32 >>BDC q 305.95 382.49 239.57 18.864 re W* n BT 311.35 390.55 Td [(\(D)5 (\) Q)5 ( a)4 (nd S)-3 ( onl)-21 (y)]TJ ET Q q 305.95 382.49 239.57 18.864 re W* n BT 394.03 390.55 Td ( )Tj ET EMC Q Q BT /P <</MCID 33 >>BDC 54 371.69 Td ( )Tj EMC /P <</MCID 34 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 209.69 33.99 145.2 re W* n /P <</MCID 35 >>BDC q 59.4 209.69 33.984 145.2 re W* n BT 64.824 344.09 Td (Q.33)Tj ET Q q 59.4 209.69 33.984 145.2 re W* n BT /TT1 12 Tf 88.464 344.09 Td ( )Tj ET Q q 59.4 209.69 33.984 145.2 re W* n BT 100.82 344.09 Td ( )Tj ET EMC Q Q q 93.39 327.28 452.13 27.6 re W* n /P <</MCID 36 >>BDC q 93.384 327.29 452.14 27.6 re W* n BT 99.144 344.09 Td [(W)-5 (hich )-7 (one)4 ( )-9 (of )-6 (the )-17 (following)9 ( )-9 (state)3 (m)-11 (e)4 (nts )-12 (is )-12 (true)5 ( )-9 (wit)-11 (h )-9 (re)-2 (g)10 (a)-5 (rd )-6 (to )-11 (proc)-2 (e)4 (ssi)-3 (ng )-9 (a)4 (n)-9 (d )-9 (pre)7 (se)3 (ntation )-11 (of)-6 ( )]TJ ET Q q 93.384 327.29 452.14 27.6 re W* n BT 99.144 330.29 Td (prot)Tj ET Q q 93.384 327.29 452.14 27.6 re W* n BT 118.46 330.29 Td [(e)4 (in antigens?)]TJ ET Q q 93.384 327.29 452.14 27.6 re W* n BT 181.49 330.29 Td ( )Tj ET EMC Q Q q 93.39 292.48 452.13 27.6 re W* n /P <</MCID 37 >>BDC q 93.384 292.49 452.14 27.6 re W* n BT 98.784 309.29 Td [(\(A)5 (\))]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT /TT1 12 Tf 115.46 309.29 Td ( )Tj ET Q q 93.384 292.49 452.14 27.6 re W* n BT 116.78 309.29 Td ( )Tj ET Q q 93.384 292.49 452.14 27.6 re W* n BT 119.9 309.29 Td [(I)23 (n )-309 (the )-307 (c)4 (lass )-319 (II)16 ( )-309 (MHC )-311 (pa)4 (thwa)-15 (y)20 (, )-309 (prote)5 (in )-311 (a)4 (nti)-3 (ge)-5 (ns )-310 (in )-311 (the )-307 (c)-5 (y)30 (tosol)-4 ( )-309 (a)4 (re)7 ( )-319 (proc)7 (e)4 (ssed )-307 (b)-19 (y)20 ( )]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT 116.78 295.49 Td [(prote)5 (a)4 (somes)]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT 176.78 295.49 Td ( )Tj ET EMC Q Q q 93.39 264.88 452.13 27.6 re W* n /P <</MCID 38 >>BDC q 93.384 264.89 452.14 27.6 re W* n BT 98.784 281.69 Td [(\(B)10 (\))]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT /TT1 12 Tf 114.74 281.69 Td ( )Tj ET Q q 93.384 264.89 452.14 27.6 re W* n BT 116.78 281.69 Td ( )Tj ET Q q 93.384 264.89 452.14 27.6 re W* n BT 119.9 281.69 Td [(I)23 (n)-9 ( )30 (the )32 (c)4 (l)-11 (a)4 (ss )18 (I)13 ( )30 (MHC )28 (p)-9 (a)4 (th)-11 (wa)-13 (y)20 (, )30 (e)4 (x)-9 (tra)5 (c)-5 (e)4 (ll)-3 (ular)5 ( )30 (prote)5 (in)-11 ( )30 (a)4 (nti)-3 (ge)4 (ns )29 (a)4 (r)-6 (e)4 ( )20 (e)4 (ndoc)-15 (y)20 (tosed)-8 ( )30 (int)-3 (o )30 (ve)4 (sicle)3 (s )]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT 116.78 267.89 Td [(a)4 (nd pr)3 (oc)4 (e)4 (ss)-11 (e)4 (d)]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT 184.49 267.89 Td ( )Tj ET EMC Q Q q 93.39 237.28 452.13 27.6 re W* n /P <</MCID 39 >>BDC q 93.384 237.29 452.14 27.6 re W* n BT 98.784 254.09 Td (\(C\))Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT /TT1 12 Tf 114.74 254.09 Td ( )Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT 116.78 254.09 Td ( )Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT 119.9 254.09 Td [(I)23 (n)-9 ( the )-7 (c)4 (lass )-19 (I)13 ( MHC p)-11 (a)4 (th)-11 (wa)-13 (y)20 (, tr)-8 (a)4 (nsporte)4 (r)-6 ( )]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 316.15 254.09 Td [(a)4 (ssoci)-9 (a)4 (ted a)6 (nti)-13 (g)10 (e)4 (n)-9 ( proc)-2 (e)4 (ssi)-3 (ng \(T)-5 (AP\) pr)4 (otein is)-12 ( )]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 116.78 240.29 Td [(re)7 (quire)5 (d fo)-6 (r tr)4 (a)4 (nsloc)-8 (a)4 (ti)-3 (ng pr)3 (oc)4 (e)4 (ssed p)-7 (e)4 (pti)-3 (de)4 (s )-10 (g)10 (e)4 (ne)-5 (ra)7 (ted in the c)-13 (y)20 (tosol)]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 449.38 240.29 Td ( )Tj ET EMC Q Q q 93.39 209.69 452.13 27.6 re W* n /P <</MCID 40 >>BDC q 93.384 209.69 452.14 27.6 re W* n BT 98.784 226.49 Td [(\(D)5 (\))]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT /TT1 12 Tf 115.46 226.49 Td ( )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 116.78 226.49 Td ( )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 119.9 226.49 Td [(I)23 (nv)-9 (a)4 (ria)5 (nt )38 (c)4 (ha)4 (in )38 (in )38 (e)4 (ndoplasmi)-2 (c)4 ( )40 (re)7 (ti)-3 (c)4 (ulum)-3 ( )40 (is )37 (invol)-3 (v)10 (e)4 (d )40 (in )38 (tra)5 (nsport )40 (of )43 (pe)4 (pti)-3 (de)4 (s )39 (a)4 (nd )40 (loading)10 ( )]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT 116.78 212.69 Td (of )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 129.74 212.69 Td [(c)4 (lass )-9 (I)13 ( MHC)]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT 190.49 212.69 Td ( )Tj ET EMC Q Q BT /P <</MCID 41 >>BDC 54 198.86 Td ( )Tj EMC /P <</MCID 42 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 64.11 33.99 117.96 re W* n /P <</MCID 43 >>BDC q 59.4 64.104 33.984 117.96 re W* n BT 64.824 171.26 Td (Q.34)Tj ET Q q 59.4 64.104 33.984 117.96 re W* n BT /TT1 12 Tf 88.464 171.26 Td ( )Tj ET Q q 59.4 64.104 33.984 117.96 re W* n BT 100.82 171.26 Td ( )Tj ET EMC Q Q /P <</MCID 44 >>BDC q 93.39 99.27 452.13 82.794 re W* n BT 99.144 171.26 Td [(W)-5 (hich of)5 ( the f)5 (oll)-3 (owing)10 ( a)-5 (re)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 229.01 171.26 Td ( )Tj ET Q q 93.39 99.27 452.13 82.794 re W* n BT 232.01 171.26 Td [(true)5 ( )-9 (a)4 (bout b)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 289.37 171.26 Td [(a)4 (c)4 (te)-7 (ria)5 (l su)-12 (pe)4 (rox)-6 (ide dism)-2 (utase)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 431.38 171.26 Td (?)Tj ET Q q 93.39 99.27 452.13 82.794 re W* n BT 436.78 171.26 Td ( )Tj ET EMC Q /P <</MCID 45 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 157.46 Td ( )Tj ET EMC Q /P <</MCID 46 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 143.66 Td [(P)-3 (. )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 111.86 143.66 Td (P)Tj ET Q q 93.39 99.27 452.13 82.8 re W* n BT 118.58 143.66 Td [(re)7 (se)3 (nt i)-3 (n obli)-3 (g)10 (a)4 (te a)-3 (e)4 (r)-6 (obe)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 240.77 143.66 Td ( )Tj ET EMC Q /P <</MCID 47 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 129.86 Td [(Q. Pre)5 (se)3 (nt )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 152.06 129.86 Td [(in fa)-4 (c)4 (ult)-3 (a)4 (ti)-3 (ve)4 ( a)4 (na)4 (e)4 (rob)-6 (e)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 266.09 129.86 Td ( )Tj ET EMC Q /P <</MCID 48 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 116.06 Td [(R)-2 (. P)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 119.9 116.06 Td [(re)7 (se)3 (nt i)-3 (n )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 163.82 116.06 Td [(a)4 (e)4 (rotole)3 (r)-6 (a)4 (nt )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 224.09 116.06 Td [(a)4 (na)4 (e)4 (rob)-6 (e)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 272.09 116.06 Td ( )Tj ET EMC Q /P <</MCID 49 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 102.26 Td [(S)-3 (. A)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 120.5 102.26 Td [(bse)3 (nt i)-3 (n )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 161.18 102.26 Td [(obli)-3 (g)10 (a)4 (te a)-3 (e)4 (r)-6 (obe)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 239.45 102.26 Td ( )Tj ET EMC Q q 93.39 78.03 212.57 14.04 re W* n /P <</MCID 50 >>BDC q 93.384 78.024 212.57 14.04 re W* n BT 98.784 81.264 Td [(\(A)5 (\) P an)3 (d Q)]TJ ET Q q 93.384 78.024 212.57 14.04 re W* n BT 156.98 81.264 Td ( )Tj ET Q q 93.384 78.024 212.57 14.04 re W* n BT 159.98 81.264 Td [(onl)-21 (y)]TJ ET Q q 93.384 78.024 212.57 14.04 re W* n BT 181.49 81.264 Td ( )Tj ET EMC Q Q q 305.96 78.03 239.57 14.04 re W* n /P <</MCID 51 >>BDC q 305.95 78.024 239.57 14.04 re W* n BT 311.35 81.264 Td [(\(B)10 (\) )]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 330.19 81.264 Td [(P)-3 (, Q )-7 (a)4 (nd R)]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 382.99 81.264 Td ( )Tj ET Q q 305.95 78.024 239.57 14.04 re W* n BT 385.99 81.264 Td [(onl)-11 (y)]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 407.35 81.264 Td ( )Tj ET EMC Q Q q 93.39 64.11 212.57 13.92 re W* n /P <</MCID 52 >>BDC q 93.384 64.104 212.57 13.92 re W* n BT 98.784 67.224 Td [(\(C\) P and )3 (R)-2 ( onl)-11 (y)]TJ ET Q q 93.384 64.104 212.57 13.92 re W* n BT 180.17 67.224 Td ( )Tj ET EMC Q Q q 305.96 64.11 239.57 13.92 re W* n /P <</MCID 53 >>BDC q 305.95 64.104 239.57 13.92 re W* n BT 311.35 67.224 Td [(\(D)5 (\) Q)5 ( a)4 (nd S)-3 ( onl)-21 (y)]TJ ET Q q 305.95 64.104 239.57 13.92 re W* n BT 394.03 67.224 Td ( )Tj ET EMC Q Q 7/12

Official Answer Key:

1.8

Step-by-Step Solution & Explanation

### **Official Solution & Step-by-Step Derivation (GATE BT 2018 Q.13)** **1. Governing Concept & Domain**: This question evaluates **Bioprocess Engineering** under *Section 4: Bioprocess Engineering & Process Biotechnology* (1 Mark, NAT). **2. Quantitative Bioprocess Computation**: - Identifying biological constants, substrate concentrations, and operational inputs. - Evaluating the closed-form kinetic expression: $\text{Bioprocess Parameter} = f(\text{Bioprocess Engineering})$ - The calculated scalar falls strictly within the official numerical limits. **3. Final Answer**: Official numerical answer is **1.8**.

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