GATE BT 2018 Question Paper & Solutions

Verbal Aptitude

"When she fell down the _______, she received many _______ but little help." The words that best fill the blanks in the above sentence are (A) stairs, stares (B) stairs, stairs (C) stares, stairs (D) stares, stares

Verbal Aptitude

"In spite of being warned repeatedly, he failed to correct his _________ behaviour." The word that best fills the blank in the above sentence is (A) rational (B) reasonable (C) errant (D) good

Quantitative & Analytical Aptitude

For 0 ≤ x ≤ 2𝜋, sin x and cos x are both decreasing functions in the interval ________. (A) (0, 𝜋 2) (B) ( 𝜋 2 , 𝜋) (C) (𝜋, 3𝜋 2 ) (D) ( 3𝜋 2 , 2𝜋)

Quantitative & Analytical Aptitude

The area of an equilateral triangle is √3. What is the perimeter of the triangle? (A) 2 (B) 4 (C) 6 (D) 8

Quantitative & Analytical Aptitude

Arrange the following three-dimensional objects in the descending order of their volumes: (i) A cuboid with dimensions 10 cm, 8 cm and 6 cm (ii) A cube of side 8 cm (iii) A cylinder with base radius 7 cm and height 7 cm (iv) A sphere of radius 7 cm

Quantitative & Analytical Aptitude

An automobile travels from city A to city B and returns to city A by the same route. The speed of the vehicle during the onward and return journeys were constant at 60 km/h and 90 km/h, respectively. What is the average speed in km/h for the entire journey? (A) 72 (B) 73 (C) 74 (D) 75 (GA) Set-4 GA 2/2

Quantitative & Analytical Aptitude

A set of 4 parallel lines intersect with another set of 5 parallel lines. How many parallelograms are formed? (A) 20 (B) 48 (C) 60 (D) 72

Quantitative & Analytical Aptitude

A mixture contains three similarly sized peptides P, Q and R. The peptide P is positively charged, Q is weakly negative and R is strongly negative. If this mixture is passed through an ion-exchange chromatography column containing an anionic resin, the ir order of elution will be (A) P, Q, R (B) R, Q, P (C) Q, R, P (D) P, Q and R elute together

Quantitative & Analytical Aptitude

Which one of the following is INCORRECT about protein structures?

Quantitative & Analytical Aptitude

Which one of the following metabolic processes in mammalian cells does NOT occur in the mitochondria? (A) Citric acid cycle (B) Oxidative phosphorylation (C) Fatty acid β-oxidation (D) Glycolysis

Biochemistry, Microbiology & Molecular Biology

Which one of the following is NOT a principal component of innate immunity?

Biochemistry, Microbiology & Molecular Biology

Which of the following technique(s) can be used to study conformational changes in myoglobin? P. Mass spectrometry Q. Fluorescence spectroscopy R. Circular dichroism spectroscopy S. Light microscopy (A) P only (B) P and S only (C) Q and R only (D) S only

Bioprocess Engineering

Which one of the following bioreactor configurations is the basis for a trickling biological filter? (A) Stirred tank (B) Packed bed (C) Air lift (D) Fluidized bed /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (3)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 711.09 33.99 76.59 re W* n /P <</MCID 0 >>BDC q 59.4 711.1 33.984 76.584 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.14)Tj ET Q q 59.4 711.1 33.984 76.584 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 711.1 33.984 76.584 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q q 93.39 746.25 452.13 41.43 re W* n /P <</MCID 1 >>BDC q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(C)-2 (e)4 (ll)-3 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 123.02 776.88 Td [(t)-11 (y)30 (p)-9 (e)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 143.54 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 147.38 776.88 Td [(A )-67 (se)3 (c)4 (r)-6 (e)4 (tes)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 197.81 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 201.65 776.88 Td [(mol)-3 (e)4 (c)4 (ule )-67 (X )-67 (int)-3 (o )-69 (the )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 302.95 776.88 Td [(c)4 (ult)-3 (ure)7 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 340.03 776.88 Td [(medium. )-71 (C)-2 (e)4 (ll)-3 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 410.11 776.88 Td [(t)-11 (y)30 (pe)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 430.54 776.88 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf -0.084 Tc 434.5 776.88 Td (B )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 446.26 776.88 Td [(in )-71 (the )-67 (sa)3 (me )-67 (c)4 (ult)-3 (ure)-2 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 763.08 Td [(re)7 (sponds )-31 (to )-31 (the )-27 (mol)-3 (e)4 (c)4 (ule)-7 ( )-29 (X )-27 (b)-9 (y)20 ( )-29 (e)4 (x)-9 (pre)7 (ssi)-3 (n)-9 (g)10 ( )-29 (prote)5 (in )-41 (Y)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 351.31 763.08 Td (.)Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 354.31 763.08 Td ( )Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 357.67 763.08 Td [(W)-5 (hich )-27 (one)4 ( )-29 (of )-26 (the )-27 (following)9 ( )-29 (modes )-28 (of)-6 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 99.144 749.26 Td [(sig)7 (na)4 (li)-3 (n)-9 (g)10 ( re)7 (p)-9 (re)]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 170.66 749.26 Td [(se)3 (nts t)-4 (he)4 ( )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 215.33 749.26 Td [(i)-11 (nter)5 (a)4 (c)4 (ti)-3 (on )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 269.69 749.26 Td [(be)4 (tw)-9 (e)4 (e)4 (n A )-7 (a)4 (n)-9 (d )]TJ ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf -0.084 Tc 344.83 749.26 Td (B?)Tj ET Q q 93.384 746.26 452.14 41.424 re W* n BT /TT0 12 Tf 358.15 749.26 Td ( )Tj ET EMC Q Q q 93.39 725.01 212.57 14.04 re W* n /P <</MCID 2 >>BDC q 93.384 725.02 212.57 14.04 re W* n BT /TT0 12 Tf 98.784 728.26 Td [(\(A)5 (\) A)5 (utoc)-7 (rine)5 ( )]TJ ET Q q 93.384 725.02 212.57 14.04 re W* n BT /TT0 12 Tf 169.46 728.26 Td ( )Tj ET EMC Q Q q 305.96 725.01 239.57 14.04 re W* n /P <</MCID 3 >>BDC q 305.95 725.02 239.57 14.04 re W* n BT /TT0 12 Tf 311.35 728.26 Td [(\(B)10 (\) J)-7 (ux)-9 (tac)6 (rine)5 ( )]TJ ET Q q 305.95 725.02 239.57 14.04 re W* n BT /TT0 12 Tf 382.63 728.26 Td ( )Tj ET EMC Q Q q 93.39 711.09 212.57 13.92 re W* n /P <</MCID 4 >>BDC q 93.384 711.1 212.57 13.92 re W* n BT /TT0 12 Tf 98.784 714.22 Td [(\(C\) Par)6 (a)4 (c)-5 (rine)5 ( )]TJ ET Q q 93.384 711.1 212.57 13.92 re W* n BT /TT0 12 Tf 166.1 714.22 Td ( )Tj ET EMC Q Q q 305.96 711.09 239.57 13.92 re W* n /P <</MCID 5 >>BDC q 305.95 711.1 239.57 13.92 re W* n BT /TT0 12 Tf 311.35 714.22 Td [(\(D)5 (\) )-6 (I)13 (ntr)-8 (a)4 (c)4 (rine)5 ( )]TJ ET Q q 305.95 711.1 239.57 13.92 re W* n BT /TT0 12 Tf 380.59 714.22 Td ( )Tj ET EMC Q Q BT /P <</MCID 6 >>BDC /TT0 11.04 Tf 54 701.14 Td ( )Tj EMC /P <</MCID 7 >>BDC 0 -12.72 Td ( )Tj EMC ET q 59.4 608.01 33.99 77.76 re W* n /P <</MCID 8 >>BDC q 59.4 608.02 33.984 77.76 re W* n BT /TT0 12 Tf 64.824 674.98 Td (Q.15)Tj ET Q q 59.4 608.02 33.984 77.76 re W* n BT /TT1 12 Tf 88.464 674.98 Td ( )Tj ET Q q 59.4 608.02 33.984 77.76 re W* n BT /TT0 12 Tf 100.82 674.98 Td ( )Tj ET EMC Q Q q 93.39 671.97 452.13 13.8 re W* n /P <</MCID 9 >>BDC q 93.384 671.98 452.14 13.8 re W* n BT /TT0 12 Tf 99.144 674.98 Td [(W)-5 (hich one)6 ( of the)5 ( following)9 ( state)3 (ments i)-2 (s true)4 ( )-9 (for)6 ( )-9 (a)4 (c)4 (ti)-3 (n?)]TJ ET Q q 93.384 671.98 452.14 13.8 re W* n BT /TT0 12 Tf 366.79 674.98 Td ( )Tj ET EMC Q Q q 93.39 650.97 452.13 13.8 re W* n /P <</MCID 10 >>BDC q 93.384 650.98 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 653.98 Td [(\(A)5 (\) A)5 (c)4 (ti)-3 (n fila)3 (ment is)-2 ( stru)-9 (c)4 (tura)5 (ll)-13 (y)20 ( pol)-11 (a)4 (riz)-4 (e)4 (d a)4 (nd the)-7 ( two e)4 (nds a)3 (re)7 ( not i)-3 (de)4 (nti)-3 (c)-5 (a)4 (l)]TJ ET Q q 93.384 650.98 452.14 13.8 re W* n BT /TT0 12 Tf 468.7 653.98 Td ( )Tj ET EMC Q Q q 93.39 637.17 452.13 13.8 re W* n /P <</MCID 11 >>BDC q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 640.18 Td [(\(B)10 (\) )]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf -0.024 Tc 117.74 640.18 Td (De)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf 131.66 640.18 Td ( )Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT2 12 Tf 134.66 640.18 Td [(nov)4 (o)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 157.94 640.18 Td ( )Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 161.06 640.18 Td (a)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 166.34 640.18 Td [(c)4 (ti)-3 (n pol)-11 (y)20 (m)-11 (e)4 (riz)-4 (a)4 (ti)-3 (on is )-2 (a)4 ( sing)7 (le)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 310.99 640.18 Td (-)Tj ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 314.95 640.18 Td [(step )-8 (proc)7 (e)4 (ss)]TJ ET Q q 93.384 637.18 452.14 13.8 re W* n BT /TT0 12 Tf 373.39 640.18 Td ( )Tj ET EMC Q Q q 93.39 623.37 452.13 13.8 re W* n /P <</MCID 12 >>BDC q 93.384 623.38 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 626.38 Td [(\(C\) T)4 (he)4 ( point)-3 (e)4 (d e)4 (nd of)3 ( th)-11 (e)4 ( a)4 (c)4 (ti)-3 (n fila)3 (ments i)-2 (s the f)4 (a)-5 (st g)7 (row)5 (in)-11 (g)10 ( e)4 (nd)]TJ ET Q q 93.384 623.38 452.14 13.8 re W* n BT /TT0 12 Tf 412.63 626.38 Td ( )Tj ET EMC Q Q q 93.39 608.01 452.13 15.36 re W* n /P <</MCID 13 >>BDC q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 98.784 612.58 Td [(\(D)5 (\) )]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 118.34 612.58 Td [(Ac)6 (ti)-3 (n fo)-6 (rms spi)-2 (ndle )]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 216.77 612.58 Td [(f)-6 (iber)5 (s)]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 244.13 612.58 Td ( )Tj ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 247.13 612.58 Td [(durin)-8 (g)10 ( mi)-3 (tosi)-4 (s)]TJ ET Q q 93.384 608.02 452.14 15.36 re W* n BT /TT0 12 Tf 316.15 612.58 Td ( )Tj ET EMC Q Q BT /P <</MCID 14 >>BDC /TT0 12 Tf 54 597.22 Td ( )Tj EMC /P <</MCID 15 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 499.63 33.99 80.775 re W* n /P <</MCID 16 >>BDC q 59.4 499.63 33.984 80.784 re W* n BT 64.824 569.62 Td (Q.16)Tj ET Q q 59.4 499.63 33.984 80.784 re W* n BT /TT1 12 Tf 88.464 569.62 Td ( )Tj ET Q q 59.4 499.63 33.984 80.784 re W* n BT 100.82 569.62 Td ( )Tj ET EMC Q Q q 93.39 566.61 452.13 13.8 re W* n /P <</MCID 17 >>BDC q 93.384 566.62 452.14 13.8 re W* n BT 99.144 569.62 Td [(S)-3 (tanda)6 (rd e)7 (rr)6 (o)-9 (r is)]TJ ET Q q 93.384 566.62 452.14 13.8 re W* n BT 179.18 569.62 Td ( )Tj ET EMC Q Q q 93.39 545.59 452.13 13.8 re W* n /P <</MCID 18 >>BDC q 93.384 545.59 452.14 13.8 re W* n BT 98.784 548.59 Td [(\(A)5 (\) the)5 ( prob)-6 (a)4 (bil)-3 (it)-13 (y)20 ( of )-6 (a)4 ( ty)18 (p)-9 (e)4 ( )-19 (I)13 ( e)4 (r)-6 (ror)6 ( in a sta)3 (ti)-3 (sti)-4 (c)4 (a)4 (l )-11 (test)]TJ ET Q q 93.384 545.59 452.14 13.8 re W* n BT 355.75 548.59 Td ( )Tj ET EMC Q Q q 93.39 531.79 452.13 13.8 re W* n /P <</MCID 19 >>BDC q 93.384 531.79 452.14 13.8 re W* n BT 98.784 534.79 Td (\()Tj ET Q q 93.384 531.79 452.14 13.8 re W* n BT 102.74 534.79 Td [(B)7 (\) the)5 ( )-9 (e)4 (rr)6 (o)-9 (r in e)5 (sti)-4 (mating)8 ( a)4 ( s)-10 (a)4 (mpl)-3 (e)4 ( standa)5 (rd d)-6 (e)4 (vi)-11 (a)4 (ti)-3 (on)]TJ ET Q q 93.384 531.79 452.14 13.8 re W* n BT 360.79 534.79 Td ( )Tj ET EMC Q Q q 93.39 518 452.13 13.8 re W* n /P <</MCID 20 >>BDC q 93.384 517.99 452.14 13.8 re W* n BT 98.784 520.99 Td [(\(C\) the)5 ( standa)5 (rd d)-6 (e)4 (viation of a)5 ( va)4 (ri)-8 (a)4 (ble tha)4 (t follo)-12 (ws standa)6 (rd no)3 (rma)5 (l di)-3 (stri)-11 (buti)-3 (on)]TJ ET Q q 93.384 517.99 452.14 13.8 re W* n BT 485.86 520.99 Td ( )Tj ET EMC Q Q q 93.39 499.64 452.13 18.36 re W* n /P <</MCID 21 >>BDC q 93.384 499.63 452.14 18.36 re W* n BT 98.784 507.19 Td [(\(D)5 (\) the)5 ( standa)-4 (rd de)7 (viatio)-11 (n of d)3 (ist)-4 (ributi)-2 (on of)3 ( sa)3 (mpl)-3 (e)4 ( mea)6 (ns)]TJ ET Q q 93.384 499.63 452.14 18.36 re W* n BT 379.51 507.19 Td ( )Tj ET EMC Q Q BT /P <</MCID 22 >>BDC 54 488.83 Td ( )Tj EMC /P <</MCID 23 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 378.28 33.99 93.75 re W* n /P <</MCID 24 >>BDC q 59.4 378.29 33.984 93.744 re W* n BT 64.824 461.23 Td (Q.17)Tj ET Q q 59.4 378.29 33.984 93.744 re W* n BT /TT1 12 Tf 88.464 461.23 Td ( )Tj ET Q q 59.4 378.29 33.984 93.744 re W* n BT 100.82 461.23 Td ( )Tj ET EMC Q Q q 93.39 444.43 452.13 27.6 re W* n /P <</MCID 25 >>BDC q 93.384 444.43 452.14 27.6 re W* n BT 99.144 461.23 Td [(W)-5 (hich one)6 ( of th)-8 (e)4 ( followi)-10 (ng)10 ( t)-11 (e)4 (c)4 (hniques is)-11 ( use)3 (d to)-11 ( )-9 (mo)]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 353.35 461.23 Td [(nit)-3 (or RNA)4 ( tra)5 (nsc)-6 (ripts)]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 457.42 461.23 Td (,)Tj ET Q q 93.384 444.43 452.14 27.6 re W* n BT 460.42 461.23 Td ( )Tj ET Q q 93.384 444.43 452.14 27.6 re W* n BT 463.42 461.23 Td [(both t)-3 (e)4 (mpora)5 (ll)-23 (y)20 ( )]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 99.144 447.43 Td [(a)4 (nd spa)3 (ti)-3 (a)4 (ll)-13 (y)30 (?)-15 ( )]TJ ET Q q 93.384 444.43 452.14 27.6 re W* n BT 168.5 447.43 Td ( )Tj ET EMC Q Q q 93.39 423.43 452.13 13.8 re W* n /P <</MCID 26 >>BDC q 93.384 423.43 452.14 13.8 re W* n BT 98.784 426.43 Td [(\(A)5 (\))]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT /TT1 12 Tf 115.46 426.43 Td ( )Tj ET Q q 93.384 423.43 452.14 13.8 re W* n BT 116.78 426.43 Td ( )Tj ET Q q 93.384 423.43 452.14 13.8 re W* n BT 119.78 426.43 Td [(Nor)5 (ther)5 (n b)]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT 171.98 426.43 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 423.43 452.14 13.8 re W* n BT 203.45 426.43 Td ( )Tj ET EMC Q Q q 93.39 409.63 452.13 13.8 re W* n /P <</MCID 27 >>BDC q 93.384 409.63 452.14 13.8 re W* n BT 98.784 412.63 Td [(\(B)10 (\))]TJ ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 412.63 Td ( )Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT2 12 Tf 116.78 412.63 Td (In s)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT /TT2 12 Tf 0.024 Tc 134.42 412.63 Td (itu)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 147.14 412.63 Td ( )Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 150.14 412.63 Td (h)Tj ET Q q 93.384 409.63 452.14 13.8 re W* n BT 156.26 412.63 Td [(y)20 (bridiz)-6 (a)4 (ti)-3 (on)]TJ ET Q q 93.384 409.63 452.14 13.8 re W* n BT 214.13 412.63 Td ( )Tj ET EMC Q Q q 93.39 395.83 452.13 13.8 re W* n /P <</MCID 28 >>BDC q 93.384 395.83 452.14 13.8 re W* n BT 98.784 398.83 Td (\(C\))Tj ET Q q 93.384 395.83 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 398.83 Td ( )Tj ET Q q 93.384 395.83 452.14 13.8 re W* n BT 116.78 398.83 Td [(S)-3 (outher)5 (n b)]TJ ET Q q 93.384 395.83 452.14 13.8 re W* n BT 169.1 398.83 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 395.83 452.14 13.8 re W* n BT 200.45 398.83 Td ( )Tj ET EMC Q Q q 93.39 378.28 452.13 17.55 re W* n /P <</MCID 29 >>BDC q 93.384 378.29 452.14 17.544 re W* n BT 98.784 385.03 Td [(\(D)5 (\))]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT /TT1 12 Tf 115.46 385.03 Td ( )Tj ET Q q 93.384 378.29 452.14 17.544 re W* n BT 116.78 385.03 Td [(W)-5 (e)4 (ster)4 (n b)]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT 165.74 385.03 Td [(lot)-3 (ti)-3 (ng)]TJ ET Q q 93.384 378.29 452.14 17.544 re W* n BT 197.09 385.03 Td ( )Tj ET EMC Q Q BT /P <</MCID 30 >>BDC 54 367.49 Td ( )Tj EMC /P <</MCID 31 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 232.6 33.99 118.08 re W* n /P <</MCID 32 >>BDC q 59.4 232.61 33.984 118.08 re W* n BT 64.824 339.89 Td (Q.18)Tj ET Q q 59.4 232.61 33.984 118.08 re W* n BT /TT1 12 Tf 88.464 339.89 Td ( )Tj ET Q q 59.4 232.61 33.984 118.08 re W* n BT 100.82 339.89 Td ( )Tj ET EMC Q Q /P <</MCID 33 >>BDC q 93.39 267.89 452.13 82.797 re W* n BT 99.144 339.89 Td [(I)13 (d)-9 (e)4 (nti)-3 (f)-16 (y)20 ( the c)6 (h)-9 (a)4 (ra)-2 (c)4 (ter)5 ( ba)4 (s)-10 (e)4 (d method\()3 (s\) use)5 (d )-9 (for)6 ( the)-7 ( c)4 (onst)-2 (ruc)7 (ti)-3 (on of)3 ( a)4 ( ph)-19 (y)20 (lo)-11 (ge)4 (ne)4 (ti)-3 (c)4 ( tre)-4 (e)4 (.)]TJ ET Q q 93.39 267.89 452.13 82.797 re W* n BT 516.1 339.89 Td ( )Tj ET EMC Q /P <</MCID 34 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 326.09 Td ( )Tj ET EMC Q /P <</MCID 35 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 312.29 Td [(P)-3 (. Ma)3 (x)-9 (im)-3 (u)10 (m par)5 (sim)-4 (on)-9 (y)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 215.45 312.29 Td ( )Tj ET EMC Q /P <</MCID 36 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT -0.024 Tc 99.144 298.49 Td (Q.)Tj ET Q q 93.39 267.88 452.13 82.8 re W* n BT 110.78 298.49 Td ( )Tj ET Q q 93.39 267.88 452.13 82.8 re W* n BT 113.78 298.49 Td [(Ne)6 (i)-11 (g)10 (hbor )3 (joi)-3 (ning)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 196.13 298.49 Td ( )Tj ET EMC Q /P <</MCID 37 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 284.69 Td [(R)-2 (. Ma)3 (x)-9 (im)-3 (u)10 (m l)-3 (ikelihood)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 214.97 284.69 Td ( )Tj ET EMC Q /P <</MCID 38 >>BDC q 93.39 267.88 452.13 82.8 re W* n BT 99.144 270.89 Td [(S)-3 (. B)7 (ootst)-4 (ra)7 (pping)]TJ ET Q q 93.39 267.88 452.13 82.8 re W* n BT 179.81 270.89 Td ( )Tj ET EMC Q q 93.39 246.64 212.57 14.04 re W* n /P <</MCID 39 >>BDC q 93.384 246.65 212.57 14.04 re W* n BT 98.784 249.89 Td [(\(A)5 (\) )]TJ ET Q q 93.384 246.65 212.57 14.04 re W* n BT 118.34 249.89 Td (Q)Tj ET Q q 93.384 246.65 212.57 14.04 re W* n BT 126.98 249.89 Td ( )Tj ET Q q 93.384 246.65 212.57 14.04 re W* n BT 129.98 249.89 Td [(onl)-21 (y)]TJ ET Q q 93.384 246.65 212.57 14.04 re W* n BT 151.46 249.89 Td ( )Tj ET EMC Q Q q 305.96 246.64 239.57 14.04 re W* n /P <</MCID 40 >>BDC q 305.95 246.65 239.57 14.04 re W* n BT 311.35 249.89 Td [(\(B)10 (\) P an)3 (d R)-2 ( onl)-21 (y)]TJ ET Q q 305.95 246.65 239.57 14.04 re W* n BT 392.71 249.89 Td ( )Tj ET EMC Q Q q 93.39 232.6 212.57 14.04 re W* n /P <</MCID 41 >>BDC q 93.384 232.61 212.57 14.04 re W* n BT 98.784 235.85 Td (\(C\) )Tj ET Q q 93.384 232.61 212.57 14.04 re W* n BT 117.74 235.85 Td [(Q a)6 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 232.61 212.57 14.04 re W* n BT 180.77 235.85 Td ( )Tj ET EMC Q Q q 305.96 232.6 239.57 14.04 re W* n /P <</MCID 42 >>BDC q 305.95 232.61 239.57 14.04 re W* n BT 311.35 235.85 Td [(\(D)5 (\))]TJ ET Q q 305.95 232.61 239.57 14.04 re W* n BT 327.91 235.85 Td ( )Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 330.91 235.85 Td (S)Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 337.63 235.85 Td ( )Tj ET Q q 305.95 232.61 239.57 14.04 re W* n BT 340.63 235.85 Td [(onl)-11 (y)]TJ ET Q q 305.95 232.61 239.57 14.04 re W* n BT 361.99 235.85 Td ( )Tj ET EMC Q Q BT /P <</MCID 43 >>BDC 54 221.81 Td ( )Tj EMC /P <</MCID 44 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 154.35 33.99 50.655 re W* n /P <</MCID 45 >>BDC q 59.4 154.34 33.984 50.664 re W* n BT 64.824 194.18 Td (Q.19)Tj ET Q q 59.4 154.34 33.984 50.664 re W* n BT /TT1 12 Tf 88.464 194.18 Td ( )Tj ET Q q 59.4 154.34 33.984 50.664 re W* n BT 100.82 194.18 Td ( )Tj ET EMC Q Q q 93.39 176.31 452.13 28.695 re W* n /P <</MCID 46 >>BDC q 93.384 176.3 452.14 28.704 re W* n BT 99.144 193.7 Td [(W)-5 (hich )-47 (one)4 ( )-49 (of)]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 165.62 193.7 Td ( )Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 169.22 193.7 Td [(the )-47 (following)9 ( )-49 (is )-52 (the )-47 (solut)-4 (ion)]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 306.31 193.7 Td ( )Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 309.91 193.7 Td (for)Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 323.83 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 326.47 193.7 Td [<073F074B>3 <074F>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 344.47 198.14 Td <0B36>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 349.87 193.7 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 356.71 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 361.99 193.7 Td <0D45>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 373.63 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 376.27 193.7 Td <0374>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 382.87 193.7 Td [<073F074B>3 <074F0754>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 407.11 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 412.39 193.7 Td <0D45>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 424.06 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 426.7 193.7 Td <0373>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 433.3 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 439.3 193.7 Td <0D4C>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 451.66 193.7 Td <0003>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 454.3 193.7 Td <0372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 460.9 193.7 Td <2C>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 463.9 193.7 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 467.5 193.7 Td [<666F>-6 <7220>-46 <7661>4 <6C75657320>-48 <6F6620>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 533.02 193.7 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 539.76 193.7 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 99.144 179.18 Td [<696E2074>-3 <6865>4 <207261>7 <6E>-9 <67>10 <65>4 <206F66>]TJ ET Q q 93.384 176.3 452.14 28.704 re W* n BT 168.62 179.18 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 171.62 179.18 Td <20>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 174.74 179.18 Td <0372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 181.37 183.62 Td <03B9>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 188.45 179.18 Td <0D4F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 200.81 179.18 Td <0754>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf 210.89 179.18 Td <0D4F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 12 Tf -0.048 Tc 223.25 179.18 Td <037503780372>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT /C2_0 8.52 Tf 243.05 183.62 Td <03B9>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 246.77 179.18 Td <3F>Tj ET Q q 93.384 176.3 452.14 28.704 re W* n BT 252.17 179.18 Td <20>Tj ET EMC Q Q q 93.39 154.35 106.22 14.76 re W* n /P <</MCID 47 >>BDC q 93.384 154.34 106.22 14.76 re W* n BT 98.784 157.34 Td [<2841>5 <2920>]TJ ET Q q 93.384 154.34 106.22 14.76 re W* n BT 118.34 157.34 Td <3435>Tj ET Q q 93.384 154.34 106.22 14.76 re W* n BT /C0_0 12 Tf 130.34 157.34 Td <0071>Tj ET Q q 93.384 154.34 106.22 14.76 re W* n BT 135.26 157.34 Td <20>Tj ET EMC Q Q q 199.61 154.35 106.35 14.76 re W* n /P <</MCID 48 >>BDC q 199.61 154.34 106.34 14.76 re W* n BT 205.01 157.34 Td [<2842>10 <29203930>]TJ ET Q q 199.61 154.34 106.34 14.76 re W* n BT /C0_0 12 Tf 235.85 157.34 Td <0071>Tj ET Q q 199.61 154.34 106.34 14.76 re W* n BT 240.77 157.34 Td <20>Tj ET EMC Q Q q 305.96 154.35 106.2 14.76 re W* n /P <</MCID 49 >>BDC q 305.95 154.34 106.2 14.76 re W* n BT 311.35 157.34 Td <2843292020>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT 333.31 157.34 Td <313830>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT /C0_0 12 Tf 351.31 157.34 Td <0071>Tj ET Q q 305.95 154.34 106.2 14.76 re W* n BT 356.11 157.34 Td <20>Tj ET EMC Q Q q 412.16 154.35 133.36 14.76 re W* n /P <</MCID 50 >>BDC q 412.15 154.34 133.37 14.76 re W* n BT 417.55 157.34 Td [<2844>5 <292020323730>]TJ ET Q q 412.15 154.34 133.37 14.76 re W* n BT /C0_0 12 Tf 458.14 157.34 Td <0071>Tj ET Q q 412.15 154.34 133.37 14.76 re W* n BT 463.06 157.34 Td <20>Tj ET EMC Q Q BT /P <</MCID 51 >>BDC 54 143.54 Td <20>Tj EMC /P <</MCID 52 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 86.91 33.99 39.84 re W* n /P <</MCID 53 >>BDC q 59.4 86.904 33.984 39.84 re W* n BT 64.824 115.94 Td <512E3230>Tj ET Q q 59.4 86.904 33.984 39.84 re W* n BT /TT1 12 Tf 88.464 115.94 Td ( )Tj ET Q q 59.4 86.904 33.984 39.84 re W* n BT 100.82 115.94 Td ( )Tj ET EMC Q Q q 93.39 112.95 452.13 13.8 re W* n /P <</MCID 54 >>BDC q 93.384 112.94 452.14 13.8 re W* n BT 99.144 115.94 Td [(W)-5 (hich one)6 ( of the)5 ( following)9 ( )]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 234.65 115.94 Td [(plant se)-6 (c)4 (onda)4 (r)-16 (y)20 ( m)-11 (e)4 (ta)]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 336.79 115.94 Td [(boli)-3 (tes is a na)6 (tura)5 (l i)-3 (nse)3 (c)4 (ti)-3 (c)4 (ide)]TJ ET Q q 93.384 112.94 452.14 13.8 re W* n BT 478.66 115.94 Td (?)Tj ET Q q 93.384 112.94 452.14 13.8 re W* n BT 484.06 115.94 Td ( )Tj ET EMC Q Q q 93.39 86.91 106.22 18.84 re W* n /P <</MCID 55 >>BDC q 93.384 86.904 106.22 18.84 re W* n BT 98.784 94.944 Td [(\(A)5 (\) )]TJ ET Q q 93.384 86.904 106.22 18.84 re W* n BT 118.34 94.944 Td [(Di)-9 (g)10 (it)-3 (ox)-9 (in)]TJ ET Q q 93.384 86.904 106.22 18.84 re W* n BT 164.42 94.944 Td ( )Tj ET EMC Q Q q 199.61 86.91 106.35 18.84 re W* n /P <</MCID 56 >>BDC q 199.61 86.904 106.34 18.84 re W* n BT 205.01 94.944 Td [(\(B)10 (\) )]TJ ET Q q 199.61 86.904 106.34 18.84 re W* n BT 223.85 94.944 Td [(P)-23 (y)20 (r)-6 (e)4 (thrin)]TJ ET Q q 199.61 86.904 106.34 18.84 re W* n BT 268.73 94.944 Td ( )Tj ET EMC Q Q q 305.96 86.91 106.2 18.84 re W* n /P <</MCID 57 >>BDC q 305.95 86.904 106.2 18.84 re W* n BT 311.35 94.944 Td (\(C\) )Tj ET Q q 305.95 86.904 106.2 18.84 re W* n BT 330.31 94.944 Td [(S)-3 (a)4 (li)-3 (c)-5 (y)]TJ ET Q q 305.95 86.904 106.2 18.84 re W* n BT 360.19 94.944 Td [(li)-3 (c)4 ( )-9 (a)4 (c)4 (i)]TJ ET Q q 305.95 86.904 106.2 18.84 re W* n BT 389.23 94.944 Td (d)Tj ET Q q 305.95 86.904 106.2 18.84 re W* n BT 395.35 94.944 Td ( )Tj ET EMC Q Q q 412.16 86.91 133.36 18.84 re W* n /P <</MCID 58 >>BDC q 412.15 86.904 133.37 18.84 re W* n BT 417.55 94.944 Td [(\(D)5 (\) )]TJ ET Q q 412.15 86.904 133.37 18.84 re W* n BT 437.14 94.944 Td [(Ave)6 (n)-9 (a)4 (c)4 (in A)]TJ ET Q q 412.15 86.904 133.37 18.84 re W* n BT 494.86 94.944 Td (-)Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 498.82 94.944 Td (1)Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 504.82 94.944 Td ( )Tj ET Q q 412.15 86.904 133.37 18.84 re W* n BT 510.94 94.944 Td ( )Tj ET EMC Q Q BT /P <</MCID 59 >>BDC 54 76.104 Td ( )Tj EMC /P <</MCID 60 >>BDC 0 -13.8 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (4)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 737.61 33.99 50.07 re W* n /P <</MCID 0 >>BDC q 59.4 737.62 33.984 50.064 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.21)Tj ET Q q 59.4 737.62 33.984 50.064 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 737.62 33.984 50.064 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q /P <</MCID 1 >>BDC q 93.39 737.62 452.13 50.064 re W* n BT /TT0 12 Tf 99.144 766.44 Td [(The)5 ( de)4 (ter)5 (mi)-3 (na)4 (nt of th)-10 (e)4 ( matr)3 (ix)]TJ ET Q q 93.39 737.62 452.13 50.064 re W* n BT /TT0 12 Tf 243.17 766.44 Td ( )Tj ET EMC Q /P <</MCID 2 >>BDC q 0.70347 0 0 0.50347 246.06 751.37 cm /GS0 gs /TT0 8.04 Tf 0 TL/Fm0 Do Q EMC /P <</MCID 3 >>BDC q 93.39 737.62 452.13 50.064 re W* n BT /GS1 gs /TT0 12 Tf 296.69 766.44 Td ( )Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 0.024 Tc 299.71 766.44 Td (is)Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 307.75 766.44 Td ( )Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 310.75 766.44 Td (_________)Tj ET Q q 93.39 737.62 452.13 50.064 re W* n BT /GS0 gs /TT0 12 Tf 364.75 766.44 Td ( )Tj ET EMC Q /P <</MCID 4 >>BDC q 93.39 737.61 452.13 50.07 re W* n BT /GS0 gs /TT0 12 Tf 99.144 740.62 Td ( )Tj ET EMC Q BT /P <</MCID 5 >>BDC /GS0 gs /TT0 12 Tf 54 719.62 Td ( )Tj EMC /P <</MCID 6 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 660.69 33.99 42.12 re W* n /P <</MCID 7 >>BDC q 59.4 660.7 33.984 42.12 re W* n BT 64.824 692.02 Td (Q.22)Tj ET Q q 59.4 660.7 33.984 42.12 re W* n BT /TT1 12 Tf 88.464 692.02 Td ( )Tj ET Q q 59.4 660.7 33.984 42.12 re W* n BT 100.82 692.02 Td ( )Tj ET EMC Q Q /P <</MCID 8 >>BDC q 93.39 660.7 452.13 42.114 re W* n BT 99.144 691.66 Td [(The)5 ( )-409 (va)-5 (ria)5 (ble )]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 172.34 691.66 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 178.34 691.66 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 186.29 691.66 Td [<6861>4 <7320>-420 <61>4 <20>-419 <7374616E6461>5 <726420>-406 <6E6F>-9 <726D61>5 <6C20>-411 <64697374>-4 <726962757469>-2 <6F6E2E20>-419 <49>13 <6620>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 396.43 691.66 Td <0732>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 404.11 691.66 Td <123A>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 409.15 691.66 Td <0372>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 419.14 691.66 Td <0D51>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 431.5 691.66 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 440.86 691.66 Td <0D51>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 453.1 691.66 Td <0373>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 459.82 691.66 Td <123B>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 466.42 691.66 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 470.74 691.66 Td <0D4C>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 482.98 691.66 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 485.62 691.66 Td <0372>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 492.34 691.66 Td <01E4>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf -0.048 Tc 494.86 691.66 Td <03750376>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 508.06 691.66 Td [<2C20>-409 <7468656E>-7 <20>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 542.76 691.66 Td <202020>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 551.76 691.66 Td <20202020>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 99.144 677.38 Td <0732>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 106.82 677.38 Td <123A>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 111.86 677.38 Td <0756>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 8.52 Tf 118.22 681.82 Td <0B36>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 125.3 677.38 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 129.62 677.38 Td <0D50>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 141.98 677.38 Td <0003>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 144.62 677.38 Td <0373>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT /C2_0 12 Tf 151.22 677.38 Td <123B>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 156.26 677.38 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 159.26 677.38 Td [<69732065717561>5 <6C2074>-3 <6F2020>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 214.61 677.38 Td [<28757020746F2074776F206465>-4 <63>4 <696D>-3 <61>4 <6C20706C>-3 <61>4 <63>4 <65>4 <7329>]TJ ET Q q 93.39 660.7 452.13 42.114 re W* n BT 341.83 677.38 Td <20>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 344.83 677.38 Td <5F5F5F5F5F5F5F5F5F>Tj ET Q q 93.39 660.7 452.13 42.114 re W* n BT 398.95 677.38 Td <20>Tj ET EMC Q /P <</MCID 9 >>BDC q 93.39 660.69 452.13 42.12 re W* n BT 99.144 663.7 Td <20>Tj ET EMC Q BT /P <</MCID 10 >>BDC 54 642.7 Td <20>Tj EMC /P <</MCID 11 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 569.85 33.99 56.04 re W* n /P <</MCID 12 >>BDC q 59.4 569.86 33.984 56.04 re W* n BT 64.824 615.1 Td <512E3233>Tj ET Q q 59.4 569.86 33.984 56.04 re W* n BT /TT1 12 Tf 88.464 615.1 Td ( )Tj ET Q q 59.4 569.86 33.984 56.04 re W* n BT 100.82 615.1 Td ( )Tj ET EMC Q Q /P <</MCID 13 >>BDC q 93.39 569.86 452.13 56.034 re W* n BT 99.144 615.1 Td [(The)5 ( )-19 (a)4 (bs)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 136.94 615.1 Td [(orba)7 (n)-9 (c)4 (e)4 ( )-19 (of )-16 (a)4 ( )-19 (solut)-4 (ion )-21 (of )-16 (tr)-8 (y)30 (ptophan )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 310.03 615.1 Td [(me)-7 (a)4 (su)-10 (re)7 (d )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 359.35 615.1 Td [(a)4 (t )-21 (280 )-19 (nm )-21 (in )-21 (a)4 ( )-19 (c)4 (uve)4 (tt)6 (e)4 ( )-19 (of )-16 (2.0 )-19 (c)4 (m )-21 (pa)4 (th)8 ( )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 99.144 600.34 Td [(leng)12 (th )-141 (is )-142 (0.56)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 167.42 600.34 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 172.1 600.34 Td [(a)4 (t )-141 (pH )-137 (7)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 210.77 600.34 Td [(. )-129 (The)5 ( )-139 (mol)-3 (a)4 (r )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 274.25 600.34 Td [(e)4 (x)-9 (ti)-3 (nc)4 (ti)-3 (on)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 322.27 600.34 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 326.95 600.34 Td [(c)4 (oe)4 (ff)6 (icie)4 (nt )-141 (\()]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT /C0_0 12 Tf 386.83 600.34 Td <0048>Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 391.99 600.34 Td [<2920>-136 <666F72>6 <20>-139 <7472>-18 <79>20 <70746F7068>-11 <61>4 <6E20>-139 <61>4 <7420>-141 <32383020>-139 <6E6D20>-131 <69>8 <73>9 <20>]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 542.76 600.34 Td <202020202020>Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 99.144 586.66 Td [<3536303020>40 <4D>]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 136.34 591.22 Td (-)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 138.98 591.22 Td (1)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT -0.048 Tc 143.06 586.66 Td (cm)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 157.7 591.22 Td (-)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 160.34 591.22 Td (1)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT /TT0 8.04 Tf 164.42 591.22 Td ( )Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 166.22 586.66 Td [(a)4 (t )38 (pH )42 (7)]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 200.57 586.66 Td [(. )40 (The)5 ( )40 (c)4 (onc)-5 (e)4 (ntra)5 (ti)-3 (on )40 (o)-9 (f )43 (tr)-18 (y)20 (pto)-11 (pha)4 (n )40 (\(in )41 (\265)-3 (M\) )42 (in )38 (th)-11 (e)4 ( )40 (solut)-4 (ion )38 ( )40 (is )]TJ ET Q q 93.39 569.86 452.13 56.034 re W* n BT 485.74 586.66 Td (__)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 497.74 586.66 Td (_______)Tj ET Q q 93.39 569.86 452.13 56.034 re W* n BT 539.76 586.66 Td ( )Tj ET EMC Q /P <</MCID 14 >>BDC q 93.39 569.85 452.13 56.04 re W* n BT 99.144 572.86 Td ( )Tj ET EMC Q BT /P <</MCID 15 >>BDC 54 551.83 Td ( )Tj EMC /P <</MCID 16 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 493.63 33.99 41.4 re W* n /P <</MCID 17 >>BDC q 59.4 493.63 33.984 41.4 re W* n BT 64.824 524.23 Td (Q.24)Tj ET Q q 59.4 493.63 33.984 41.4 re W* n BT /TT1 12 Tf 88.464 524.23 Td ( )Tj ET Q q 59.4 493.63 33.984 41.4 re W* n BT 100.82 524.23 Td ( )Tj ET EMC Q Q /P <</MCID 18 >>BDC q 93.39 493.63 452.13 41.397 re W* n BT 99.144 524.23 Td [(A )-17 (sing)7 (le)-7 ( )-19 (stem )-20 (c)4 (e)4 (ll)-3 ( )-19 (und)-9 (e)4 (r)-6 (g)10 (oe)4 (s)-10 ( )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 242.09 524.23 Td (10)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 254.09 524.23 Td ( )Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 257.33 524.23 Td [(a)4 (s)-20 (y)20 (mm)-3 (e)4 (tric)-6 ( )-19 (c)4 (e)4 (ll)-3 ( )-29 (divi)-3 (s)]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 360.67 524.23 Td [(ions. )-22 (The)5 ( )-19 (number)5 ( )-19 (of)-6 ( )-19 (stem )-20 (c)4 (e)4 (ll)]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 505.18 524.23 Td (s)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 509.86 524.23 Td ( )Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 513.1 524.23 Td [(a)4 (t )-21 (the)-7 ( )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 99.144 510.43 Td [(e)4 (nd is )]TJ ET Q q 93.39 493.63 452.13 41.397 re W* n BT 130.46 510.43 Td (_________)Tj ET Q q 93.39 493.63 452.13 41.397 re W* n BT 184.49 510.43 Td ( )Tj ET EMC Q /P <</MCID 19 >>BDC q 93.39 493.63 452.13 41.4 re W* n BT 99.144 496.63 Td ( )Tj ET EMC Q BT /P <</MCID 20 >>BDC 54 475.63 Td ( )Tj EMC /P <</MCID 21 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 403.63 33.99 55.2 re W* n /P <</MCID 22 >>BDC q 59.4 403.63 33.984 55.2 re W* n BT 64.824 448.03 Td (Q.25)Tj ET Q q 59.4 403.63 33.984 55.2 re W* n BT /TT1 12 Tf 88.464 448.03 Td ( )Tj ET Q q 59.4 403.63 33.984 55.2 re W* n BT 100.82 448.03 Td ( )Tj ET EMC Q Q /P <</MCID 23 >>BDC q 93.39 403.63 452.13 55.197 re W* n BT 99.144 448.03 Td [(Ge)6 (nomi)-3 (c)4 ( )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT -0.024 Tc 148.7 448.03 Td (DNA )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 180.29 448.03 Td [(isol)-4 (a)4 (ted)-7 ( )-219 (fr)6 (om )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT -0.048 Tc 252.29 448.03 Td (a )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 263.21 448.03 Td [(ba)4 (c)4 (ter)5 (ium)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 311.11 448.03 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 316.75 448.03 Td [(wa)6 (s)-10 ( )-219 (dig)8 (e)4 (sted )-218 (with )-221 (a)4 ( )-219 (re)7 (strict)-9 (ion )-221 (e)4 (nz)-15 (y)30 (m)-11 (e)4 ( )-219 (that )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 99.144 434.23 Td [(re)7 (c)4 (o)-9 (g)10 (niz)-7 (e)4 (s a)3 ( 6)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 167.66 434.23 Td (-)Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 171.62 434.23 Td [(ba)4 (se)3 ( pa)4 (ir)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 214.49 434.23 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 217.49 434.23 Td [(\()-6 (bp\))]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 237.53 434.23 Td ( )Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 240.53 434.23 Td [(se)3 (que)4 (nc)4 (e)4 (. Assumi)-3 (n)-9 (g)10 ( ra)]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 351.31 434.23 Td [(ndom di)-3 (stribut)-3 (ion of ba)15 (se)3 (s, the a)5 (ve)4 (ra)-2 (g)10 (e)-5 ( )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 99.144 420.43 Td [(leng)12 (th \(in bp\) o)-7 (f the)5 ( fr)-3 (a)-5 (gments g)9 (e)4 (n)-9 (e)4 (ra)7 (t)-11 (e)4 (d is )]TJ ET Q q 93.39 403.63 452.13 55.197 re W* n BT 309.79 420.43 Td (_________)Tj ET Q q 93.39 403.63 452.13 55.197 re W* n BT 363.79 420.43 Td ( )Tj ET EMC Q /P <</MCID 24 >>BDC q 93.39 403.63 452.13 55.2 re W* n BT 99.144 406.63 Td ( )Tj ET EMC Q BT /P <</MCID 25 >>BDC 54 385.63 Td ( )Tj EMC /P <</MCID 26 >>BDC /TT0 11.04 Tf 0 -12.98 Td ( )Tj 144.05 0 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (5)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q BT /P <</MCID 0 >>BDC /TT1 12.96 Tf -0.0029 Tc 54 775.56 Td (Q. )Tj 0 Tc 16.584 0 Td (26 )Tj /C2_0 12.96 Tf <00B1>Tj /TT1 12.96 Tf [( Q.)-8.002 ( )-0.725 (55 carry)-10 ( tw)-8.997 (o )-8.002 (m)8.997 (arks e)-8.997 (ach.)-14.9 ( )]TJ EMC /P <</MCID 1 >>BDC /TT0 12 Tf -16.584 -25.7 Td ( )Tj EMC ET q 59.4 638.85 33.99 108 re W* n /P <</MCID 2 >>BDC q 59.4 638.86 33.984 108 re W* n BT 64.824 736.06 Td (Q.26)Tj ET Q q 59.4 638.86 33.984 108 re W* n BT /TT2 12 Tf 88.464 736.06 Td ( )Tj ET Q q 59.4 638.86 33.984 108 re W* n BT 100.82 736.06 Td ( )Tj ET EMC Q Q q 93.39 705.45 452.13 41.4 re W* n /P <</MCID 3 >>BDC q 93.384 705.46 452.14 41.4 re W* n BT 99.144 736.06 Td [(I)13 (n )30 (le)-7 (g)10 (umi)-3 (nous )29 (plants, )29 (b)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 210.65 736.06 Td [(ot)8 (h )30 (the )32 (rhiz)-4 (obiu)8 (m )28 (g)10 (e)4 (ne)4 (s )29 (a)4 (n)-9 (d )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 347.59 736.06 Td (the )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 364.87 736.06 Td [(plant )30 (g)10 (e)4 (ne)4 (s )29 (influe)3 (nc)-5 (e)4 ( )30 (nodulation )28 (a)4 (nd)10 ( )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 99.144 722.26 Td [(nit)-3 (rog)13 (e)4 (n )-59 (fix)-8 (a)4 (ti)-3 (on. )-49 (W)-5 (h)10 (ich )-47 (o)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 228.29 722.26 Td [(ne)4 ( )-49 (of )-46 (the )-47 (followin)-10 (g)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 321.67 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 325.27 722.26 Td [(fun)-6 (c)4 (ti)-3 (ons)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 370.03 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 373.63 722.26 Td (is )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT /TT1 12 Tf 385.27 722.26 Td (NOT)Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 411.31 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 414.91 722.26 Td [(e)4 (nc)4 (ode)4 (d)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 454.78 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 458.38 722.26 Td [(b)-9 (y)20 ( )-49 (the )]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 492.1 722.26 Td (host)Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 512.14 722.26 Td ( )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 515.74 722.26 Td (plant )Tj ET Q q 93.384 705.46 452.14 41.4 re W* n BT 99.144 708.46 Td [(g)10 (e)4 (n)-9 (e)4 (s?)]TJ ET Q q 93.384 705.46 452.14 41.4 re W* n BT 131.78 708.46 Td ( )Tj ET EMC Q Q q 93.39 684.45 452.13 13.8 re W* n /P <</MCID 4 >>BDC q 93.384 684.46 452.14 13.8 re W* n BT 98.784 687.46 Td [(\(A)5 (\) Produc)6 (ti)-3 (on of)3 ( induc)-7 (e)-5 (rs tha)4 (t m)-3 (odif)-8 (y)20 ( rhiz)-4 (obial c)-5 (e)4 (ll)-3 ( wa)6 (ll)]TJ ET Q q 93.384 684.46 452.14 13.8 re W* n BT 376.15 687.46 Td ( )Tj ET EMC Q Q q 93.39 670.65 452.13 13.8 re W* n /P <</MCID 5 >>BDC q 93.384 670.66 452.14 13.8 re W* n BT 98.784 673.66 Td [(\(B)10 (\) )]TJ ET Q q 93.384 670.66 452.14 13.8 re W* n BT 117.62 673.66 Td [(P)-3 (rodu)-6 (c)4 (ti)-3 (on of)3 ( fla)5 (von)-9 (oid i)-3 (nduc)4 (e)4 (rs)]TJ ET Q q 93.384 670.66 452.14 13.8 re W* n BT 276.17 673.66 Td ( )Tj ET EMC Q Q q 93.39 656.85 452.13 13.8 re W* n /P <</MCID 6 >>BDC q 93.384 656.86 452.14 13.8 re W* n BT 98.784 659.86 Td [(\(C\) E)4 (stablis)-3 (hment of)3 ( c)4 (on)-9 (tac)6 (t betwe)-3 (e)4 (n ba)4 (c)4 (te)-7 (ria)5 ( a)4 (nd)-9 ( leg)12 (ume)]TJ ET Q q 93.384 656.86 452.14 13.8 re W* n BT 379.03 659.86 Td ( )Tj ET EMC Q Q q 93.39 638.85 452.13 18 re W* n /P <</MCID 7 >>BDC q 93.384 638.86 452.14 18 re W* n BT 98.784 646.06 Td [(\(D)5 (\) Root hair)3 ( c)4 (u)-9 (rling)]TJ ET Q q 93.384 638.86 452.14 18 re W* n BT 200.45 646.06 Td ( )Tj ET EMC Q Q BT /P <</MCID 8 >>BDC 54 628.06 Td ( )Tj EMC /P <</MCID 9 >>BDC 0 -13.68 Td ( )Tj EMC ET q 59.4 445.88 33.99 165.5 re W* n /P <</MCID 10 >>BDC q 59.4 445.87 33.984 165.5 re W* n BT 64.824 600.58 Td (Q.27)Tj ET Q q 59.4 445.87 33.984 165.5 re W* n BT /TT2 12 Tf 88.464 600.58 Td ( )Tj ET Q q 59.4 445.87 33.984 165.5 re W* n BT 100.82 600.58 Td ( )Tj ET EMC Q Q /P <</MCID 11 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 600.58 Td [(W)-5 (hich of)5 ( the f)5 (oll)-3 (owing)10 ( c)-5 (y)20 (t)-11 (okines a)-4 (re)7 ( e)4 (ndo)-9 (ge)4 (nous )-10 (p)-9 (y)20 (ro)-6 (ge)4 (ns?)]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 390.79 600.58 Td ( )Tj ET EMC Q /P <</MCID 12 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 586.78 Td ( )Tj ET EMC Q /P <</MCID 13 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 572.02 Td [(P)-3 (. Tumor ne)6 (c)4 (rosis fa)-3 (c)4 (tor)]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 217.73 572.02 Td (-)Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT /C0_0 12 Tf 221.81 572.02 Td <0044>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 229.37 572.02 Td <20>Tj ET EMC Q /P <</MCID 14 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 558.19 Td [<512E20>-7 <49>13 <6E746572>5 <6C65756B696E>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 166.34 558.19 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 170.3 558.19 Td <31>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 176.42 558.19 Td <20>Tj ET EMC Q /P <</MCID 15 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 544.39 Td [<52>-2 <2E20>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 113.18 544.39 Td [<5472>4 <61>4 <6E73666F72>5 <6D69>-3 <6E>-9 <67>10 <20>-9 <67>10 <726F77>5 <746820>-11 <6661>7 <63>4 <746F72>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 247.01 544.39 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT /C2_1 12 Tf 250.97 544.39 Td <0215>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 257.21 544.39 Td <20>Tj ET EMC Q /P <</MCID 16 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 530.59 Td [<53>-3 <2E20>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 111.86 530.59 Td <20>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 114.98 530.59 Td [<49>23 <6E746572>5 <6C>-11 <65>4 <756B696E>]TJ ET Q q 93.39 513.79 452.13 97.575 re W* n BT 167.42 530.59 Td <2D>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 171.38 530.59 Td <31>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 177.38 530.59 Td <30>Tj ET Q q 93.39 513.79 452.13 97.575 re W* n BT 183.41 530.59 Td <20>Tj ET EMC Q /P <</MCID 17 >>BDC q 93.39 513.79 452.13 97.575 re W* n BT 99.144 516.79 Td <20>Tj ET EMC Q q 93.39 492.79 452.13 13.8 re W* n /P <</MCID 18 >>BDC q 93.384 492.79 452.14 13.8 re W* n BT 98.784 495.79 Td [<2841>5 <29>]TJ ET Q q 93.384 492.79 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 495.79 Td ( )Tj ET Q q 93.384 492.79 452.14 13.8 re W* n BT 116.78 495.79 Td ( )Tj ET Q q 93.384 492.79 452.14 13.8 re W* n BT 119.78 495.79 Td [(P)-3 ( a)4 (nd Q onl)-9 (y)]TJ ET Q q 93.384 492.79 452.14 13.8 re W* n BT 182.81 495.79 Td ( )Tj ET EMC Q Q q 93.39 478.99 452.13 13.8 re W* n /P <</MCID 19 >>BDC q 93.384 478.99 452.14 13.8 re W* n BT 98.784 481.99 Td [(\(B)10 (\))]TJ ET Q q 93.384 478.99 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 481.99 Td ( )Tj ET Q q 93.384 478.99 452.14 13.8 re W* n BT 116.78 481.99 Td ( )Tj ET Q q 93.384 478.99 452.14 13.8 re W* n BT 119.78 481.99 Td [(P)-3 ( a)4 (nd R)-2 ( onl)-11 (y)]TJ ET Q q 93.384 478.99 452.14 13.8 re W* n BT 182.21 481.99 Td ( )Tj ET EMC Q Q q 93.39 465.19 452.13 13.8 re W* n /P <</MCID 20 >>BDC q 93.384 465.19 452.14 13.8 re W* n BT 98.784 468.19 Td (\(C\))Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 468.19 Td ( )Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT 116.78 468.19 Td ( )Tj ET Q q 93.384 465.19 452.14 13.8 re W* n BT 119.78 468.19 Td [(R)-2 ( a)4 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 465.19 452.14 13.8 re W* n BT 182.21 468.19 Td ( )Tj ET EMC Q Q q 93.39 445.87 452.13 19.32 re W* n /P <</MCID 21 >>BDC q 93.384 445.87 452.14 19.32 re W* n BT 98.784 454.39 Td [(\(D)5 (\))]TJ ET Q q 93.384 445.87 452.14 19.32 re W* n BT /TT2 12 Tf 115.46 454.39 Td ( )Tj ET Q q 93.384 445.87 452.14 19.32 re W* n BT 116.78 454.39 Td ( )Tj ET Q q 93.384 445.87 452.14 19.32 re W* n BT 119.78 454.39 Td [(Q a)6 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 445.87 452.14 19.32 re W* n BT 182.81 454.39 Td ( )Tj ET EMC Q Q BT /P <</MCID 22 >>BDC 54 435.07 Td ( )Tj EMC /P <</MCID 23 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 258.88 33.99 159.39 re W* n /P <</MCID 24 >>BDC q 59.4 258.89 33.984 159.38 re W* n BT 64.824 407.47 Td (Q.28)Tj ET Q q 59.4 258.89 33.984 159.38 re W* n BT /TT2 12 Tf 88.464 407.47 Td ( )Tj ET Q q 59.4 258.89 33.984 159.38 re W* n BT 100.82 407.47 Td ( )Tj ET EMC Q Q /P <</MCID 25 >>BDC q 93.39 294.05 452.13 124.22 re W* n BT 99.144 407.47 Td [(Ma)3 (tch the)4 ( c)4 (lasse)4 (s o)-10 (f RN)-7 (A molec)6 (ul)]TJ ET Q q 93.39 294.05 452.13 124.22 re W* n BT 266.81 407.47 Td [(e)4 (s in Group )-7 (I)13 ( )-9 (with t)-3 (he)4 (ir f)4 (unc)4 (ti)-3 (ons i)-2 (n Gr)-4 (oup )-9 (II)16 (.)]TJ ET Q q 93.39 294.05 452.13 124.22 re W* n BT 486.94 407.47 Td ( )Tj ET EMC Q /P <</MCID 26 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 393.67 Td ( )Tj ET EMC Q /P <</MCID 27 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 99.144 379.61 Td [(G)8 (r)4 (ou)-3 (p)-3 ( I)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 140.78 379.61 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 171.14 379.61 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 201.17 379.61 Td [(G)8 (r)4 (ou)-3 (p)-3 ( II)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT /TT1 12 Tf 247.49 379.61 Td ( )Tj ET EMC Q /P <</MCID 28 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 366.05 Td [(P)-3 (. snoR)-3 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 153.86 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 366.05 Td (1)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 366.05 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 366.05 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 366.05 Td [(P)-3 (rote)5 (c)4 (ts ger)4 (ml)-3 (ine f)5 (rom tra)6 (nspos)-11 (a)4 (ble e)6 (lem)-9 (e)4 (nts )]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 435.46 366.05 Td ( )Tj ET EMC Q /P <</MCID 29 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 352.25 Td [(Q. piR)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 148.46 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 352.25 Td (2)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 352.25 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 352.25 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 352.25 Td [(B)7 (locks tra)6 (nslati)-12 (on of)3 ( se)3 (lec)6 (ted mR)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 392.47 352.25 Td ( )Tj ET EMC Q /P <</MCID 30 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 338.45 Td [(R)-2 (. mi)-3 (R)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 151.1 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 338.45 Td (3)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 338.45 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 338.45 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 338.45 Td [(Te)5 (mpl)-3 (a)4 (te f)5 (or te)5 (l)-11 (omer)5 (e)4 ( e)4 (lon)-11 (g)10 (a)4 (ti)-3 (o)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 367.99 338.45 Td (n)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 374.11 338.45 Td ( )Tj ET EMC Q /P <</MCID 31 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 99.144 324.65 Td [(S)-3 (. snR)-3 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 147.86 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 171.14 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 324.65 Td (4.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 324.65 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 324.65 Td [(Modi)-2 (fic)5 (a)4 (ti)-3 (on a)4 (n)-9 (d pro)3 (c)4 (e)4 (ssi)-3 (n)-9 (g)10 ( of r)6 (R)-2 (NA)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 395.83 324.65 Td ( )Tj ET EMC Q /P <</MCID 32 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 171.14 310.85 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 201.17 310.85 Td (5)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 207.17 310.85 Td (.)Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 210.17 310.85 Td ( )Tj ET Q q 93.39 294.04 452.13 124.23 re W* n BT 213.17 310.85 Td [(S)-3 (pli)-3 (c)4 (ing)8 ( of RN)-7 (A tra)7 (nsc)3 (ripts)]TJ ET Q q 93.39 294.04 452.13 124.23 re W* n BT 347.59 310.85 Td ( )Tj ET EMC Q /P <</MCID 33 >>BDC q 93.39 294.04 452.13 124.23 re W* n BT 171.14 297.05 Td ( )Tj ET EMC Q q 93.39 272.8 212.57 14.04 re W* n /P <</MCID 34 >>BDC q 93.384 272.81 212.57 14.04 re W* n BT 98.784 276.05 Td [(\(A)5 (\) P)]TJ ET Q q 93.384 272.81 212.57 14.04 re W* n BT 125.06 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 129.02 276.05 Td (3)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 135.02 276.05 Td (, Q)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 149.66 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 153.62 276.05 Td (5)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 159.62 276.05 Td (, R)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 173.66 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 177.62 276.05 Td (2)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 183.65 276.05 Td (, S)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 196.37 276.05 Td (-)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 200.33 276.05 Td (4)Tj ET Q q 93.384 272.81 212.57 14.04 re W* n BT 206.45 276.05 Td ( )Tj ET EMC Q Q q 305.96 272.8 239.57 14.04 re W* n /P <</MCID 35 >>BDC q 305.95 272.81 239.57 14.04 re W* n BT 311.35 276.05 Td [(\(B)10 (\) P)]TJ ET Q q 305.95 272.81 239.57 14.04 re W* n BT 336.91 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 340.87 276.05 Td (1)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 346.87 276.05 Td (, Q)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 361.63 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 365.59 276.05 Td (3)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 371.59 276.05 Td (, R)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 385.63 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 389.59 276.05 Td (2)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 395.59 276.05 Td (, S)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 408.31 276.05 Td (-)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 412.27 276.05 Td (5)Tj ET Q q 305.95 272.81 239.57 14.04 re W* n BT 418.39 276.05 Td ( )Tj ET EMC Q Q q 93.39 258.88 212.57 13.92 re W* n /P <</MCID 36 >>BDC q 93.384 258.89 212.57 13.92 re W* n BT 98.784 262.01 Td (\(C\) P)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 124.46 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 128.42 262.01 Td (1)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 134.42 262.01 Td (, Q)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 149.06 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 153.02 262.01 Td (4)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 159.02 262.01 Td (, R)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 173.06 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 177.02 262.01 Td (5)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 183.05 262.01 Td (, S)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 195.77 262.01 Td (-)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 199.73 262.01 Td (2)Tj ET Q q 93.384 258.89 212.57 13.92 re W* n BT 205.85 262.01 Td ( )Tj ET EMC Q Q q 305.96 258.88 239.57 13.92 re W* n /P <</MCID 37 >>BDC q 305.95 258.89 239.57 13.92 re W* n BT 311.35 262.01 Td (\()Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 315.31 262.01 Td [(D\))5 ( P)]TJ ET Q q 305.95 258.89 239.57 13.92 re W* n BT 337.63 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 341.59 262.01 Td (4)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 347.59 262.01 Td (, Q)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 362.23 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 366.19 262.01 Td (1, R)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 386.23 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 390.19 262.01 Td (2)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 396.19 262.01 Td (, S)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 408.91 262.01 Td (-)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 412.87 262.01 Td (5)Tj ET Q q 305.95 258.89 239.57 13.92 re W* n BT 419.02 262.01 Td ( )Tj ET EMC Q Q BT /P <</MCID 38 >>BDC 54 248.09 Td ( )Tj EMC /P <</MCID 39 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 86.07 33.99 145.22 re W* n /P <</MCID 40 >>BDC q 59.4 86.064 33.984 145.22 re W* n BT 64.824 220.49 Td (Q.29)Tj ET Q q 59.4 86.064 33.984 145.22 re W* n BT /TT2 12 Tf 88.464 220.49 Td ( )Tj ET Q q 59.4 86.064 33.984 145.22 re W* n BT 100.82 220.49 Td ( )Tj ET EMC Q Q /P <</MCID 41 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 220.49 Td [(De)6 (ter)5 (mi)-3 (ne)4 ( the )-7 (c)4 (orr)-3 (e)4 (c)4 (tnes)-8 (s or othe)4 (rw)5 (ise of)4 ( th)-11 (e)4 ( following)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 367.27 220.49 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 370.27 220.49 Td (A)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 378.91 220.49 Td [(sse)-7 (rtion [)-7 (a)4 (])-6 ( a)4 (nd the Rea)7 (son [)-7 (r])]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 524.14 220.49 Td ( )Tj ET EMC Q /P <</MCID 42 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 206.69 Td ( )Tj ET EMC Q /P <</MCID 43 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 192.86 Td [(Asse)4 (rtion:)-2 ( )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT /TT3 12 Tf 151.7 192.86 Td [(Ab )-18 (ini)-3 (ti)-3 (o)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 193.73 192.86 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 196.97 192.86 Td [(g)10 (e)4 (ne)-5 ( )-19 (finding)9 ( )-19 (a)4 (l)-11 (g)10 (orithm)-2 (s )-20 (that)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 333.19 192.86 Td ( )Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 336.43 192.86 Td [(pre)7 (dict )-19 (prote)5 (in )-21 (c)4 (odin)-11 (g)10 ( )-29 (g)10 (e)-5 (ne)4 (s )-20 (in )-21 (e)4 (uka)4 (r)-16 (y)20 (oti)-3 (c)4 ( )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 99.144 179.06 Td [(g)10 (e)4 (nom)-11 (e)4 (s )]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 144.74 179.06 Td [(a)4 (r)-6 (e)4 ( not complet)-9 (e)4 (l)-11 (y)20 ( )-9 (a)4 (c)4 (c)4 (u)-9 (ra)7 (te)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 277.01 179.06 Td (.)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 280.13 179.06 Td ( )Tj ET EMC Q /P <</MCID 44 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 165.26 Td ( )Tj ET EMC Q /P <</MCID 45 >>BDC q 93.39 148.47 452.13 82.815 re W* n BT 99.144 151.46 Td [(R)-2 (e)4 (a)4 (son:)-2 ( Euka)5 (r)-16 (y)20 (oti)-3 (c)4 ( spl)-2 (ic)-7 (e)4 ( sit)-4 (e)4 (s a)3 (re)7 ( dif)-8 (fic)5 (ult)-3 ( to pre)-4 (dict)]TJ ET Q q 93.39 148.47 452.13 82.815 re W* n BT 356.83 151.46 Td (.)Tj ET Q q 93.39 148.47 452.13 82.815 re W* n BT 359.83 151.46 Td ( )Tj ET EMC Q q 93.39 127.47 452.13 13.8 re W* n /P <</MCID 46 >>BDC q 93.384 127.46 452.14 13.8 re W* n BT 98.784 130.46 Td [(\(A)5 (\))]TJ ET Q q 93.384 127.46 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 130.46 Td ( )Tj ET Q q 93.384 127.46 452.14 13.8 re W* n BT 116.78 130.46 Td ( )Tj ET Q q 93.384 127.46 452.14 13.8 re W* n BT 119.78 130.46 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( fa)7 (lse)]TJ ET Q q 93.384 127.46 452.14 13.8 re W* n BT 238.13 130.46 Td ( )Tj ET EMC Q Q q 93.39 113.67 452.13 13.8 re W* n /P <</MCID 47 >>BDC q 93.384 113.66 452.14 13.8 re W* n BT 98.784 116.66 Td [(\(B)10 (\))]TJ ET Q q 93.384 113.66 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 116.66 Td ( )Tj ET Q q 93.384 113.66 452.14 13.8 re W* n BT 116.78 116.66 Td ( )Tj ET Q q 93.384 113.66 452.14 13.8 re W* n BT 119.78 116.66 Td [([)-6 (a)4 (])-6 ( is )7 (true)5 ( but [)-8 (r])-3 ( is fa)4 (lse)]TJ ET Q q 93.384 113.66 452.14 13.8 re W* n BT 235.73 116.66 Td ( )Tj ET EMC Q Q q 93.39 99.87 452.13 13.8 re W* n /P <</MCID 48 >>BDC q 93.384 99.864 452.14 13.8 re W* n BT 98.784 102.86 Td (\(C\))Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT /TT2 12 Tf 114.74 102.86 Td ( )Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT 116.78 102.86 Td ( )Tj ET Q q 93.384 99.864 452.14 13.8 re W* n BT 119.78 102.86 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is t)-4 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t re)-4 (a)4 (s)-10 (on fo)3 (r [)-3 (a)4 (])]TJ ET Q q 93.384 99.864 452.14 13.8 re W* n BT 402.07 102.86 Td ( )Tj ET EMC Q Q q 93.39 86.07 452.13 13.8 re W* n /P <</MCID 49 >>BDC q 93.384 86.064 452.14 13.8 re W* n BT 98.784 89.064 Td [(\(D)5 (\))]TJ ET Q q 93.384 86.064 452.14 13.8 re W* n BT /TT2 12 Tf 115.46 89.064 Td ( )Tj ET Q q 93.384 86.064 452.14 13.8 re W* n BT 116.78 89.064 Td ( )Tj ET Q q 93.384 86.064 452.14 13.8 re W* n BT 119.78 89.064 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( but [)-8 (r])-3 ( )10 (is not)-4 ( the c)6 (orr)6 (e)4 (c)4 (t r)-8 (e)4 (a)4 (son for)5 ( [)-6 (a)4 (])]TJ ET Q q 93.384 86.064 452.14 13.8 re W* n BT 418.27 89.064 Td ( )Tj ET EMC Q Q BT /P <</MCID 50 >>BDC 54 75.264 Td ( )Tj EMC /P <</MCID 51 >>BDC 0 -13.8 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (6)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 734.01 33.99 53.67 re W* n /P <</MCID 0 >>BDC q 59.4 734.02 33.984 53.664 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.30)Tj ET Q q 59.4 734.02 33.984 53.664 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 734.02 33.984 53.664 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q q 93.39 760.08 452.13 27.6 re W* n /P <</MCID 1 >>BDC q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(W)-5 (hich )-37 (one)4 ( )-39 (of )-36 (the )-37 (followi)-10 (ng)10 ( )-39 (a)4 (mi)-3 (no )-49 (a)4 (c)4 (ids )-42 (is )-42 (c)4 (a)4 (tal)-19 (y)20 (z)-15 (e)4 (d )-39 (b)-9 (y)20 ( )-49 (a)4 (c)4 (ti)-3 (va)4 (ted)-7 ( )-39 (mac)6 (roph)-6 (a)4 (ge)4 (s )-40 (to )-41 (prod)]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 523.06 776.88 Td [(uc)-5 (e)4 ( )]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 99.144 763.08 Td [(re)7 (a)4 (c)4 (ti)-3 (ve)4 ( nit)-3 (ro)-6 (ge)4 (n spe)3 (c)4 (i)-11 (e)4 (s)-10 (?)]TJ ET Q q 93.384 760.08 452.14 27.6 re W* n BT /TT0 12 Tf 223.13 763.08 Td ( )Tj ET EMC Q Q q 93.39 734.01 106.22 18.87 re W* n /P <</MCID 2 >>BDC q 93.384 734.02 106.22 18.864 re W* n BT /TT0 12 Tf 98.784 742.06 Td [(\(A)5 (\) A)5 (r)-6 (g)10 (ini)-3 (ne)]TJ ET Q q 93.384 734.02 106.22 18.864 re W* n BT /TT0 12 Tf 161.06 742.06 Td ( )Tj ET EMC Q Q q 199.61 734.01 106.35 18.87 re W* n /P <</MCID 3 >>BDC q 199.61 734.02 106.34 18.864 re W* n BT /TT0 12 Tf 205.01 742.06 Td [(\(B)10 (\) )-6 (Aspa)5 (r)-6 (a)-5 (g)10 (ine)]TJ ET Q q 199.61 734.02 106.34 18.864 re W* n BT /TT0 12 Tf 278.69 742.06 Td ( )Tj ET EMC Q Q q 305.96 734.01 106.2 18.87 re W* n /P <</MCID 4 >>BDC q 305.95 734.02 106.2 18.864 re W* n BT /TT0 12 Tf 311.35 742.06 Td [(\(C\) C)-9 (y)20 (steine)]TJ ET Q q 305.95 734.02 106.2 18.864 re W* n BT /TT0 12 Tf 375.31 742.06 Td ( )Tj ET EMC Q Q q 412.16 734.01 133.36 18.87 re W* n /P <</MCID 5 >>BDC q 412.15 734.02 133.37 18.864 re W* n BT /TT0 12 Tf 417.55 742.06 Td [(\(D)5 (\) H)5 (ist)-4 (idi)-3 (ne)]TJ ET Q q 412.15 734.02 133.37 18.864 re W* n BT /TT0 12 Tf 484.3 742.06 Td ( )Tj ET EMC Q Q BT /P <</MCID 6 >>BDC /TT0 11.04 Tf 54 724.06 Td ( )Tj EMC /P <</MCID 7 >>BDC 0 -12.72 Td ( )Tj EMC ET q 59.4 562.4 33.99 146.3 re W* n /P <</MCID 8 >>BDC q 59.4 562.39 33.984 146.3 re W* n BT /TT0 12 Tf 64.824 697.9 Td (Q.31)Tj ET Q q 59.4 562.39 33.984 146.3 re W* n BT /TT1 12 Tf 88.464 697.9 Td ( )Tj ET Q q 59.4 562.39 33.984 146.3 re W* n BT /TT0 12 Tf 100.82 697.9 Td ( )Tj ET EMC Q Q /P <</MCID 9 >>BDC q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 99.144 697.9 Td [(De)6 (ter)5 (mi)-3 (ne)4 ( the )-7 (c)4 (orr)-3 (e)4 (c)4 (tnes)-8 (s or othe)4 (rw)5 (ise of)4 ( th)-11 (e)4 ( following)9 ( A)]TJ ET Q q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 378.91 697.9 Td [(sse)-7 (rtion [)-7 (a)4 (])-6 ( a)4 (nd the Rea)7 (son [)-7 (r])]TJ ET Q q 93.39 625.9 452.13 82.794 re W* n BT /TT0 12 Tf 524.14 697.9 Td ( )Tj ET EMC Q /P <</MCID 10 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 684.1 Td ( )Tj ET EMC Q /P <</MCID 11 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 670.3 Td [(Asse)4 (rtion)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 145.1 670.3 Td [(: )-21 (The)5 ( )-19 (a)4 (ssocia)4 (ti)-3 (on )-19 (c)4 (onst)-2 (a)4 (nt )-21 (in )-21 (wa)6 (ter)5 ( )-19 (for)6 ( )-19 (the )-17 (G)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 359.35 670.3 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 363.31 670.3 Td [(C)-2 ( )-19 (ba)4 (se)3 ( )-19 (pa)4 (ir )-18 (is )-22 (th)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 441.58 670.3 Td [(re)7 (e)4 ( )-19 (ti)-3 (mes )-18 (lowe)4 (r )-16 (than )]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 656.5 Td [(that f)3 (or the)5 ( A)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 163.34 656.5 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 167.3 656.5 Td [(T b)-8 (a)4 (se)3 ( )]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 202.01 656.5 Td [(pa)4 (i)-11 (r)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 220.85 656.5 Td (.)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 223.85 656.5 Td ( )Tj ET EMC Q /P <</MCID 12 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 642.7 Td ( )Tj ET EMC Q /P <</MCID 13 >>BDC q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 99.144 628.9 Td [(R)-2 (e)4 (a)4 (son)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 134.42 628.9 Td [(: The)3 (re)7 ( )-9 (a)4 (re)7 ( th)-11 (re)7 (e)4 ( )-9 (h)-9 (y)20 (dro)-6 (ge)4 (n bonds i)-2 (n the G)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 334.99 628.9 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 339.07 628.9 Td [(C)-2 ( ba)4 (se)3 ( pa)4 (ir a)5 (nd two in t)-3 (h)-9 (e)4 ( A)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 476.02 628.9 Td (-)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 479.98 628.9 Td [(T ba)5 (s)-10 (e)4 ( pa)4 (ir)]TJ ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 533.26 628.9 Td (.)Tj ET Q q 93.39 625.89 452.13 82.8 re W* n BT /TT0 12 Tf 536.38 628.9 Td ( )Tj ET EMC Q q 93.39 604.89 452.13 13.8 re W* n /P <</MCID 14 >>BDC q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 607.9 Td [(\(A)5 (\))]TJ ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT1 12 Tf 115.46 607.9 Td ( )Tj ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 607.9 Td ( )Tj ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 607.9 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is t)-4 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t re)-4 (a)4 (s)-10 (on fo)3 (r [)-3 (a)4 (])]TJ ET Q q 93.384 604.9 452.14 13.8 re W* n BT /TT0 12 Tf 402.07 607.9 Td ( )Tj ET EMC Q Q q 93.39 591.09 452.13 13.8 re W* n /P <</MCID 15 >>BDC q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 594.1 Td [(\(B)10 (\))]TJ ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 594.1 Td ( )Tj ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 594.1 Td ( )Tj ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 594.1 Td [([)-6 (a)4 (])-6 ( is fa)4 (lse but [)-7 (r)13 (])-6 ( is t)-4 (rue)]TJ ET Q q 93.384 591.1 452.14 13.8 re W* n BT /TT0 12 Tf 235.73 594.1 Td ( )Tj ET EMC Q Q q 93.39 577.29 452.13 13.8 re W* n /P <</MCID 16 >>BDC q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 98.784 580.3 Td (\(C\))Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT1 12 Tf 114.74 580.3 Td ( )Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 116.78 580.3 Td ( )Tj ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 119.78 580.3 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)]TJ ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 186.89 580.3 Td [(r])-3 ( a)4 (re)7 ( fa)7 (lse)]TJ ET Q q 93.384 577.3 452.14 13.8 re W* n BT /TT0 12 Tf 238.13 580.3 Td ( )Tj ET EMC Q Q q 93.39 562.4 452.13 14.895 re W* n /P <</MCID 17 >>BDC q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 98.784 566.5 Td [(\(D)5 (\))]TJ ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT1 12 Tf 115.46 566.5 Td ( )Tj ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 116.78 566.5 Td ( )Tj ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 119.78 566.5 Td [(B)7 (oth [)-8 (a)4 (])-6 ( a)4 (nd [)-6 (r])-3 ( a)4 (re)7 ( true)5 ( a)4 (nd [)-6 (r])-3 ( is no)-2 (t t)-3 (he)4 ( c)4 (orr)6 (e)4 (c)4 (t r)-8 (e)4 (a)4 (son for)5 ( [)-6 (a)4 (])]TJ ET Q q 93.384 562.39 452.14 14.904 re W* n BT /TT0 12 Tf 420.34 566.5 Td ( )Tj ET EMC Q Q BT /P <</MCID 18 >>BDC /TT0 12 Tf 54 551.59 Td ( )Tj EMC /P <</MCID 19 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 382.48 33.99 152.31 re W* n /P <</MCID 20 >>BDC q 59.4 382.49 33.984 152.3 re W* n BT 64.824 523.99 Td (Q.32)Tj ET Q q 59.4 382.49 33.984 152.3 re W* n BT /TT1 12 Tf 88.464 523.99 Td ( )Tj ET Q q 59.4 382.49 33.984 152.3 re W* n BT 100.82 523.99 Td ( )Tj ET EMC Q Q /P <</MCID 21 >>BDC q 93.39 422.6 452.13 112.2 re W* n BT 99.144 523.99 Td [(W)-5 (hich )12 (one)4 ( )10 (of )13 (the )12 (c)4 (ombi)-3 (na)4 (ti)-3 (ons )9 (of )13 (the )12 (following)9 ( )10 (st)-12 (a)4 (teme)4 (nts )7 (is )7 (true)5 ( )10 (a)4 (bout )8 (a)4 (nt)-11 (ibod)-11 (y)20 ( )10 (struc)4 (tur)-8 (e)14 (?)]TJ ET Q q 93.39 422.6 452.13 112.2 re W* n BT 539.76 523.99 Td ( )Tj ET EMC Q /P <</MCID 22 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 510.19 Td ( )Tj ET EMC Q /P <</MCID 23 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 496.39 Td [(P)-3 (. )-9 (L)21 (im)-3 (it)-3 (e)4 (d pro)3 (teol)-19 (y)30 (sis)-3 ( of )-6 (ra)7 (bbit)-3 ( )-9 (I)13 (gG w)4 (it)-3 (h the e)6 (nz)-25 (y)10 (me pe)6 (psin g)-2 (e)4 (ne)4 (r)-6 (a)4 (tes two )-8 (a)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 465.46 496.39 Td [(nti)-3 (g)10 (e)4 (n)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 495.46 496.39 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 499.42 496.39 Td [(bindi)-3 (ng)10 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 539.04 496.39 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 542.16 496.39 Td ( )Tj ET EMC Q /P <</MCID 24 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 482.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 114.14 482.59 Td [(re)-2 (g)10 (ions \(F)-3 (a)4 (b\) a)7 (nd )-9 (a)4 (n )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT -0.072 Tc 216.17 482.59 Td (Fc)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 228.05 482.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 231.05 482.59 Td [(f)-6 (ra)-2 (g)10 (ment)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 274.49 482.59 Td ( )Tj ET EMC Q /P <</MCID 25 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 468.79 Td [(Q. )-7 (L)21 (im)-3 (it)-3 (e)4 (d pro)3 (teol)-19 (y)20 (sis)-3 ( of)-6 ( ra)7 (bbit)-3 ( )-9 (I)13 (gG w)4 (it)-3 (h the e)6 (nz)-25 (y)10 (me pa)6 (pa)4 (in )-11 (g)10 (e)4 (n)-9 (e)4 (ra)7 (tes )-8 (a)4 ( sing)7 (le biva)4 (l)-11 (e)4 (nt )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 523.42 468.79 Td ( )Tj ET EMC Q /P <</MCID 26 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 454.03 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 114.14 454.03 Td [(a)4 (nti)-3 (g)10 (e)4 (n)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 149.42 454.03 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 153.38 454.03 Td [(bindi)-3 (ng)10 ( )-9 (re)-2 (g)10 (io)-11 (n F)6 (\(a)7 (b)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT /C0_0 12 Tf 248.69 454.03 Td <0063>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 251.69 454.03 Td <29>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT /TT0 8.04 Tf 255.65 453.07 Td [(2)-5.995 ( )-3.01 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 263.81 454.03 Td [(a)4 (nd pe)4 (pti)-3 (de)4 ( fr)-3 (a)-5 (g)10 (ments)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 370.51 454.03 Td ( )Tj ET EMC Q /P <</MCID 27 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 440.35 Td [(R)-2 (. The)5 ( )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT -0.072 Tc 134.78 440.35 Td (Fc)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 146.66 440.35 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 149.78 440.35 Td [(fr)6 (a)-5 (g)10 (ment of)3 ( )-19 (I)13 (g)-9 (G c)6 (a)4 (n se)3 (lf)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 267.77 440.35 Td (-)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 271.73 440.35 Td [(a)4 (ssocia)4 (t)-11 (e)4 ( a)4 (nd )-9 (c)4 (r)-16 (y)20 (stalli)-4 (z)-5 (e)4 ( int)-3 (o )]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 412.51 440.35 Td [(a)4 ( latti)-3 (c)4 (e)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 450.1 440.35 Td ( )Tj ET EMC Q /P <</MCID 28 >>BDC q 93.39 422.59 452.13 112.2 re W* n BT 99.144 425.59 Td [(S)-3 (. The)5 ( F)6 (\(a)7 (b)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT /C0_0 12 Tf 155.3 425.59 Td <0063>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 158.3 425.59 Td <29>Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT /TT0 8.04 Tf 0.06 Tc 162.26 424.63 Td (2 )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 168.38 425.59 Td ( )Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 171.38 425.59 Td [(fr)6 (a)-5 (g)10 (m)-11 (e)4 (nt of )-8 (I)13 (gG is c)3 (ompos)-2 (e)4 (d of b)3 (o)-9 (th l)-3 (ig)8 (ht and he)6 (a)4 (v)-19 (y)20 ( )-9 (c)4 (ha)4 (in)]TJ ET Q q 93.39 422.59 452.13 112.2 re W* n BT 455.26 425.59 Td (s)Tj ET Q q 93.39 422.59 452.13 112.2 re W* n BT 460.06 425.59 Td ( )Tj ET EMC Q q 93.39 401.35 212.57 14.04 re W* n /P <</MCID 29 >>BDC q 93.384 401.35 212.57 14.04 re W* n BT 98.784 404.59 Td [(\(A)5 (\) P an)3 (d Q onl)-19 (y)]TJ ET Q q 93.384 401.35 212.57 14.04 re W* n BT 181.49 404.59 Td ( )Tj ET EMC Q Q q 305.96 401.35 239.57 14.04 re W* n /P <</MCID 30 >>BDC q 305.95 401.35 239.57 14.04 re W* n BT 311.35 404.59 Td [(\(B)10 (\) P an)3 (d R)-2 ( onl)-21 (y)]TJ ET Q q 305.95 401.35 239.57 14.04 re W* n BT 392.71 404.59 Td ( )Tj ET EMC Q Q q 93.39 382.48 212.57 18.87 re W* n /P <</MCID 31 >>BDC q 93.384 382.49 212.57 18.864 re W* n BT 98.784 390.55 Td [(\(C\) R a)4 (nd S)-3 ( onl)-11 (y)]TJ ET Q q 93.384 382.49 212.57 18.864 re W* n BT 180.17 390.55 Td ( )Tj ET EMC Q Q q 305.96 382.48 239.57 18.87 re W* n /P <</MCID 32 >>BDC q 305.95 382.49 239.57 18.864 re W* n BT 311.35 390.55 Td [(\(D)5 (\) Q)5 ( a)4 (nd S)-3 ( onl)-21 (y)]TJ ET Q q 305.95 382.49 239.57 18.864 re W* n BT 394.03 390.55 Td ( )Tj ET EMC Q Q BT /P <</MCID 33 >>BDC 54 371.69 Td ( )Tj EMC /P <</MCID 34 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 209.69 33.99 145.2 re W* n /P <</MCID 35 >>BDC q 59.4 209.69 33.984 145.2 re W* n BT 64.824 344.09 Td (Q.33)Tj ET Q q 59.4 209.69 33.984 145.2 re W* n BT /TT1 12 Tf 88.464 344.09 Td ( )Tj ET Q q 59.4 209.69 33.984 145.2 re W* n BT 100.82 344.09 Td ( )Tj ET EMC Q Q q 93.39 327.28 452.13 27.6 re W* n /P <</MCID 36 >>BDC q 93.384 327.29 452.14 27.6 re W* n BT 99.144 344.09 Td [(W)-5 (hich )-7 (one)4 ( )-9 (of )-6 (the )-17 (following)9 ( )-9 (state)3 (m)-11 (e)4 (nts )-12 (is )-12 (true)5 ( )-9 (wit)-11 (h )-9 (re)-2 (g)10 (a)-5 (rd )-6 (to )-11 (proc)-2 (e)4 (ssi)-3 (ng )-9 (a)4 (n)-9 (d )-9 (pre)7 (se)3 (ntation )-11 (of)-6 ( )]TJ ET Q q 93.384 327.29 452.14 27.6 re W* n BT 99.144 330.29 Td (prot)Tj ET Q q 93.384 327.29 452.14 27.6 re W* n BT 118.46 330.29 Td [(e)4 (in antigens?)]TJ ET Q q 93.384 327.29 452.14 27.6 re W* n BT 181.49 330.29 Td ( )Tj ET EMC Q Q q 93.39 292.48 452.13 27.6 re W* n /P <</MCID 37 >>BDC q 93.384 292.49 452.14 27.6 re W* n BT 98.784 309.29 Td [(\(A)5 (\))]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT /TT1 12 Tf 115.46 309.29 Td ( )Tj ET Q q 93.384 292.49 452.14 27.6 re W* n BT 116.78 309.29 Td ( )Tj ET Q q 93.384 292.49 452.14 27.6 re W* n BT 119.9 309.29 Td [(I)23 (n )-309 (the )-307 (c)4 (lass )-319 (II)16 ( )-309 (MHC )-311 (pa)4 (thwa)-15 (y)20 (, )-309 (prote)5 (in )-311 (a)4 (nti)-3 (ge)-5 (ns )-310 (in )-311 (the )-307 (c)-5 (y)30 (tosol)-4 ( )-309 (a)4 (re)7 ( )-319 (proc)7 (e)4 (ssed )-307 (b)-19 (y)20 ( )]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT 116.78 295.49 Td [(prote)5 (a)4 (somes)]TJ ET Q q 93.384 292.49 452.14 27.6 re W* n BT 176.78 295.49 Td ( )Tj ET EMC Q Q q 93.39 264.88 452.13 27.6 re W* n /P <</MCID 38 >>BDC q 93.384 264.89 452.14 27.6 re W* n BT 98.784 281.69 Td [(\(B)10 (\))]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT /TT1 12 Tf 114.74 281.69 Td ( )Tj ET Q q 93.384 264.89 452.14 27.6 re W* n BT 116.78 281.69 Td ( )Tj ET Q q 93.384 264.89 452.14 27.6 re W* n BT 119.9 281.69 Td [(I)23 (n)-9 ( )30 (the )32 (c)4 (l)-11 (a)4 (ss )18 (I)13 ( )30 (MHC )28 (p)-9 (a)4 (th)-11 (wa)-13 (y)20 (, )30 (e)4 (x)-9 (tra)5 (c)-5 (e)4 (ll)-3 (ular)5 ( )30 (prote)5 (in)-11 ( )30 (a)4 (nti)-3 (ge)4 (ns )29 (a)4 (r)-6 (e)4 ( )20 (e)4 (ndoc)-15 (y)20 (tosed)-8 ( )30 (int)-3 (o )30 (ve)4 (sicle)3 (s )]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT 116.78 267.89 Td [(a)4 (nd pr)3 (oc)4 (e)4 (ss)-11 (e)4 (d)]TJ ET Q q 93.384 264.89 452.14 27.6 re W* n BT 184.49 267.89 Td ( )Tj ET EMC Q Q q 93.39 237.28 452.13 27.6 re W* n /P <</MCID 39 >>BDC q 93.384 237.29 452.14 27.6 re W* n BT 98.784 254.09 Td (\(C\))Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT /TT1 12 Tf 114.74 254.09 Td ( )Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT 116.78 254.09 Td ( )Tj ET Q q 93.384 237.29 452.14 27.6 re W* n BT 119.9 254.09 Td [(I)23 (n)-9 ( the )-7 (c)4 (lass )-19 (I)13 ( MHC p)-11 (a)4 (th)-11 (wa)-13 (y)20 (, tr)-8 (a)4 (nsporte)4 (r)-6 ( )]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 316.15 254.09 Td [(a)4 (ssoci)-9 (a)4 (ted a)6 (nti)-13 (g)10 (e)4 (n)-9 ( proc)-2 (e)4 (ssi)-3 (ng \(T)-5 (AP\) pr)4 (otein is)-12 ( )]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 116.78 240.29 Td [(re)7 (quire)5 (d fo)-6 (r tr)4 (a)4 (nsloc)-8 (a)4 (ti)-3 (ng pr)3 (oc)4 (e)4 (ssed p)-7 (e)4 (pti)-3 (de)4 (s )-10 (g)10 (e)4 (ne)-5 (ra)7 (ted in the c)-13 (y)20 (tosol)]TJ ET Q q 93.384 237.29 452.14 27.6 re W* n BT 449.38 240.29 Td ( )Tj ET EMC Q Q q 93.39 209.69 452.13 27.6 re W* n /P <</MCID 40 >>BDC q 93.384 209.69 452.14 27.6 re W* n BT 98.784 226.49 Td [(\(D)5 (\))]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT /TT1 12 Tf 115.46 226.49 Td ( )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 116.78 226.49 Td ( )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 119.9 226.49 Td [(I)23 (nv)-9 (a)4 (ria)5 (nt )38 (c)4 (ha)4 (in )38 (in )38 (e)4 (ndoplasmi)-2 (c)4 ( )40 (re)7 (ti)-3 (c)4 (ulum)-3 ( )40 (is )37 (invol)-3 (v)10 (e)4 (d )40 (in )38 (tra)5 (nsport )40 (of )43 (pe)4 (pti)-3 (de)4 (s )39 (a)4 (nd )40 (loading)10 ( )]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT 116.78 212.69 Td (of )Tj ET Q q 93.384 209.69 452.14 27.6 re W* n BT 129.74 212.69 Td [(c)4 (lass )-9 (I)13 ( MHC)]TJ ET Q q 93.384 209.69 452.14 27.6 re W* n BT 190.49 212.69 Td ( )Tj ET EMC Q Q BT /P <</MCID 41 >>BDC 54 198.86 Td ( )Tj EMC /P <</MCID 42 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 64.11 33.99 117.96 re W* n /P <</MCID 43 >>BDC q 59.4 64.104 33.984 117.96 re W* n BT 64.824 171.26 Td (Q.34)Tj ET Q q 59.4 64.104 33.984 117.96 re W* n BT /TT1 12 Tf 88.464 171.26 Td ( )Tj ET Q q 59.4 64.104 33.984 117.96 re W* n BT 100.82 171.26 Td ( )Tj ET EMC Q Q /P <</MCID 44 >>BDC q 93.39 99.27 452.13 82.794 re W* n BT 99.144 171.26 Td [(W)-5 (hich of)5 ( the f)5 (oll)-3 (owing)10 ( a)-5 (re)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 229.01 171.26 Td ( )Tj ET Q q 93.39 99.27 452.13 82.794 re W* n BT 232.01 171.26 Td [(true)5 ( )-9 (a)4 (bout b)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 289.37 171.26 Td [(a)4 (c)4 (te)-7 (ria)5 (l su)-12 (pe)4 (rox)-6 (ide dism)-2 (utase)]TJ ET Q q 93.39 99.27 452.13 82.794 re W* n BT 431.38 171.26 Td (?)Tj ET Q q 93.39 99.27 452.13 82.794 re W* n BT 436.78 171.26 Td ( )Tj ET EMC Q /P <</MCID 45 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 157.46 Td ( )Tj ET EMC Q /P <</MCID 46 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 143.66 Td [(P)-3 (. )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 111.86 143.66 Td (P)Tj ET Q q 93.39 99.27 452.13 82.8 re W* n BT 118.58 143.66 Td [(re)7 (se)3 (nt i)-3 (n obli)-3 (g)10 (a)4 (te a)-3 (e)4 (r)-6 (obe)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 240.77 143.66 Td ( )Tj ET EMC Q /P <</MCID 47 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 129.86 Td [(Q. Pre)5 (se)3 (nt )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 152.06 129.86 Td [(in fa)-4 (c)4 (ult)-3 (a)4 (ti)-3 (ve)4 ( a)4 (na)4 (e)4 (rob)-6 (e)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 266.09 129.86 Td ( )Tj ET EMC Q /P <</MCID 48 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 116.06 Td [(R)-2 (. P)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 119.9 116.06 Td [(re)7 (se)3 (nt i)-3 (n )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 163.82 116.06 Td [(a)4 (e)4 (rotole)3 (r)-6 (a)4 (nt )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 224.09 116.06 Td [(a)4 (na)4 (e)4 (rob)-6 (e)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 272.09 116.06 Td ( )Tj ET EMC Q /P <</MCID 49 >>BDC q 93.39 99.27 452.13 82.8 re W* n BT 99.144 102.26 Td [(S)-3 (. A)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 120.5 102.26 Td [(bse)3 (nt i)-3 (n )]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 161.18 102.26 Td [(obli)-3 (g)10 (a)4 (te a)-3 (e)4 (r)-6 (obe)4 (s)]TJ ET Q q 93.39 99.27 452.13 82.8 re W* n BT 239.45 102.26 Td ( )Tj ET EMC Q q 93.39 78.03 212.57 14.04 re W* n /P <</MCID 50 >>BDC q 93.384 78.024 212.57 14.04 re W* n BT 98.784 81.264 Td [(\(A)5 (\) P an)3 (d Q)]TJ ET Q q 93.384 78.024 212.57 14.04 re W* n BT 156.98 81.264 Td ( )Tj ET Q q 93.384 78.024 212.57 14.04 re W* n BT 159.98 81.264 Td [(onl)-21 (y)]TJ ET Q q 93.384 78.024 212.57 14.04 re W* n BT 181.49 81.264 Td ( )Tj ET EMC Q Q q 305.96 78.03 239.57 14.04 re W* n /P <</MCID 51 >>BDC q 305.95 78.024 239.57 14.04 re W* n BT 311.35 81.264 Td [(\(B)10 (\) )]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 330.19 81.264 Td [(P)-3 (, Q )-7 (a)4 (nd R)]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 382.99 81.264 Td ( )Tj ET Q q 305.95 78.024 239.57 14.04 re W* n BT 385.99 81.264 Td [(onl)-11 (y)]TJ ET Q q 305.95 78.024 239.57 14.04 re W* n BT 407.35 81.264 Td ( )Tj ET EMC Q Q q 93.39 64.11 212.57 13.92 re W* n /P <</MCID 52 >>BDC q 93.384 64.104 212.57 13.92 re W* n BT 98.784 67.224 Td [(\(C\) P and )3 (R)-2 ( onl)-11 (y)]TJ ET Q q 93.384 64.104 212.57 13.92 re W* n BT 180.17 67.224 Td ( )Tj ET EMC Q Q q 305.96 64.11 239.57 13.92 re W* n /P <</MCID 53 >>BDC q 305.95 64.104 239.57 13.92 re W* n BT 311.35 67.224 Td [(\(D)5 (\) Q)5 ( a)4 (nd S)-3 ( onl)-21 (y)]TJ ET Q q 305.95 64.104 239.57 13.92 re W* n BT 394.03 67.224 Td ( )Tj ET EMC Q Q 7/12

Biochemistry, Microbiology & Molecular Biology

Question 14 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 15 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 16 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 17 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 18 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 19 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 20 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 21 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 22 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 23 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 24 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 25 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 26 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 27 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 28 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 29 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 30 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 31 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 32 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 33 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 34 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Which of the following are true with regard to anaerobic respiration in bacteria? P. The final electron acceptor is an inorganic substance other than molecular oxygen Q. The number of ATP molecules produced per glucose molecule is more than that produced in aerobic respiration R. The number of ATP molecules produced per glucose molecule is less than that produced in aerobic respiration S. Only substrate level phosphorylation is used to generate ATP (A) P and S only (B) Q and S only (C) P and R only (D) P, Q and S only

Biochemistry, Microbiology & Molecular Biology

Shear stress versus shear rate behavior of four different types of fluids (I, II, III and IV) are shown in the figure below. Which one of the following options is correct?

Engineering Mathematics

An analysis of DNA-protein interactions was carried out using all DNA -protein complexes in the protein data bank (PDB). The frequency distribution of four amino acid residues , represented as P, Q, R and S, occurring in non-covalent interactions between the protein and DNA backbone is shown below. Which one of the following is correct? (A) P-Lys, Q-Arg, R-Gln, S-Glu (B) P-Gln, Q-Glu, R-Lys, S-Arg (C) P-Asn, Q-Asp, R-Arg, S-Lys (D) P-His, Q-Glu, R-Gln, S-Lys

Biochemistry, Microbiology & Molecular Biology

A pedigree of an inheritable disease is shown below. What type of inheritance does the disease follow? (A) Autosomal dominant (B) X-linked dominant (C) X-linked recessive (D) Autosomal recessive /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 526.78 37.704 Td (9)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 533.02 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 625.17 33.99 162.51 re W* n /P <</MCID 0 >>BDC q 59.4 625.18 33.984 162.5 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.39)Tj ET Q q 59.4 625.18 33.984 162.5 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 625.18 33.984 162.5 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q /P <</MCID 1 >>BDC q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(Ma)3 (tch )-227 (the )]TJ ET Q q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 155.9 776.88 Td [(indus)-2 (tria)3 (l )]TJ ET Q q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 207.05 776.88 Td [(pr)-6 (oduc)4 (ts )-232 (mentioned )-227 (in )-231 (Gr)-4 (oup )-239 (I)13 ( )-229 (with )-231 (their)3 ( )-229 (produ)-6 (c)-5 (e)4 (r )-226 (or)-6 (ga)4 (nism)-4 (s )-230 (in)8 ( )]TJ ET Q q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 542.76 776.88 Td ( )Tj ET Q q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 99.144 763.08 Td [(Gr)5 (oup )-9 (II)]TJ ET Q q 93.39 663.46 452.13 124.22 re W* n BT /TT0 12 Tf 140.78 763.08 Td ( )Tj ET EMC Q /P <</MCID 2 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 99.144 749.26 Td ( )Tj ET EMC Q /P <</MCID 3 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT2 12 Tf 99.144 735.22 Td [(G)8 (r)4 (ou)-3 (p)-3 ( I)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT2 12 Tf 140.78 735.22 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT2 12 Tf 171.14 735.22 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT2 12 Tf 201.17 735.22 Td [(G)8 (r)4 (ou)-3 (p)-3 ( II)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT2 12 Tf 247.49 735.22 Td ( )Tj ET EMC Q /P <</MCID 4 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 0.048 Tc 99.144 721.66 Td (P.)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 108.86 721.66 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 111.86 721.66 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 114.86 721.66 Td [(C)-2 (it)-3 (ric)5 ( a)4 (c)4 (id)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 165.14 721.66 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 171.14 721.66 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 201.17 721.66 Td (1)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 207.17 721.66 Td (. )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT3 12 Tf 213.17 721.66 Td [(T)-3 (richode)5 (rma v)5 (iri)-4 (de)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 306.79 721.66 Td ( )Tj ET EMC Q /P <</MCID 5 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 99.144 707.86 Td [(Q. Cellul)-2 (a)4 (se)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 158.42 707.86 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 171.14 707.86 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 201.17 707.86 Td (2)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 207.17 707.86 Td (. )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT3 12 Tf 213.17 707.86 Td [(C)-2 (lost)-4 (ridi)-4 (um ac)6 (e)4 (tobut)-3 (y)4 (li)-3 (c)4 (um)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 346.87 707.86 Td ( )Tj ET EMC Q /P <</MCID 6 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 99.144 694.06 Td [(R)-2 (. Vitamin B)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT 163.46 693.1 Td [(1)-5.995 (2)-6.007 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 201.65 694.06 Td (3.)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 210.65 694.06 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT3 12 Tf 213.65 694.06 Td [(A)11 (spe)3 (rgil)-4 (lus ni)-4 (ge)4 (r)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 296.57 694.06 Td ( )Tj ET EMC Q /P <</MCID 7 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 0.048 Tc 99.144 680.26 Td (S.)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 108.86 680.26 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 111.86 680.26 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 114.86 680.26 Td [(B)7 (utanol)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 152.78 680.26 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 171.14 680.26 Td ( )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 201.17 680.26 Td (4)Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 207.17 680.26 Td (. )Tj ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT3 12 Tf 213.17 680.26 Td [(Propioni)-3 (bac)4 (terium freude)6 (nre)3 (ichii)]TJ ET Q q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 375.55 680.26 Td ( )Tj ET EMC Q /P <</MCID 8 >>BDC q 93.39 663.45 452.13 124.23 re W* n BT /TT0 12 Tf 99.144 666.46 Td ( )Tj ET EMC Q q 93.39 642.21 212.57 14.04 re W* n /P <</MCID 9 >>BDC q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 98.784 645.46 Td [(\(A)5 (\) P)]TJ ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 125.06 645.46 Td (-)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 129.02 645.46 Td (4)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 135.02 645.46 Td (, Q)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 149.66 645.46 Td (-)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 153.62 645.46 Td (3)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 159.62 645.46 Td (, R)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 173.66 645.46 Td (-)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 177.62 645.46 Td (1)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 183.65 645.46 Td (, S)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 196.37 645.46 Td (-)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 200.33 645.46 Td (2)Tj ET Q q 93.384 642.22 212.57 14.04 re W* n BT /TT0 12 Tf 206.45 645.46 Td ( )Tj ET EMC Q Q q 305.96 642.21 239.57 14.04 re W* n /P <</MCID 10 >>BDC q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 311.35 645.46 Td (\()Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 315.31 645.46 Td [(B)7 (\) P)]TJ ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 336.91 645.46 Td (-)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 340.87 645.46 Td (3)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 346.87 645.46 Td (, Q)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 361.63 645.46 Td (-)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 365.59 645.46 Td (1)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 371.59 645.46 Td (, R)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 385.63 645.46 Td (-)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 389.59 645.46 Td (2)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 395.59 645.46 Td (, S)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 408.31 645.46 Td (-)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 412.27 645.46 Td (4)Tj ET Q q 305.95 642.22 239.57 14.04 re W* n BT /TT0 12 Tf 418.39 645.46 Td ( )Tj ET EMC Q Q q 93.39 625.17 212.57 17.04 re W* n /P <</MCID 11 >>BDC q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 98.784 631.42 Td (\(C\) P)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 124.46 631.42 Td (-)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 128.42 631.42 Td (2, Q)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 149.06 631.42 Td (-)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 153.02 631.42 Td (1, R)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 173.06 631.42 Td (-)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 177.02 631.42 Td (4)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 183.05 631.42 Td (, S)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 195.77 631.42 Td (-)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 199.73 631.42 Td (3)Tj ET Q q 93.384 625.18 212.57 17.04 re W* n BT /TT0 12 Tf 205.85 631.42 Td ( )Tj ET EMC Q Q q 305.96 625.17 239.57 17.04 re W* n /P <</MCID 12 >>BDC q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 311.35 631.42 Td [(\(D)5 (\) P)]TJ ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 337.63 631.42 Td (-)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 341.59 631.42 Td (3, Q)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 362.23 631.42 Td (-)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 366.19 631.42 Td (1)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 372.19 631.42 Td (, R)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 386.23 631.42 Td (-)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 390.19 631.42 Td (4)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 396.19 631.42 Td (, S)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 408.91 631.42 Td (-)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 412.87 631.42 Td (2)Tj ET Q q 305.95 625.18 239.57 17.04 re W* n BT /TT0 12 Tf 419.02 631.42 Td ( )Tj ET EMC Q Q BT /P <</MCID 13 >>BDC /TT0 12 Tf 54 614.38 Td ( )Tj EMC /P <</MCID 14 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 445.75 33.99 151.82 re W* n /P <</MCID 15 >>BDC q 59.4 445.75 33.984 151.82 re W* n BT 64.824 586.78 Td (Q.40)Tj ET Q q 59.4 445.75 33.984 151.82 re W* n BT /TT1 12 Tf 88.464 586.78 Td ( )Tj ET Q q 59.4 445.75 33.984 151.82 re W* n BT 100.82 586.78 Td ( )Tj ET EMC Q Q /P <</MCID 16 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 585.82 Td (5)Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 105.14 585.82 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 108.14 585.82 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 111.14 585.82 Td [<63>4 <61>4 <7070696E67>8 <206F>-9 <66206D524E41207472>3 <61>4 <6E>-9 <7363>3 <726970747320>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 255.77 585.82 Td [<696E2065756B61>6 <72>-16 <79>20 <6F74657320>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 322.99 585.82 Td [<696E76>-11 <6F6C7665>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 359.11 585.82 Td <73>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 363.79 585.82 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 366.79 585.82 Td [<7468652066>5 <6F6C6C>-3 <6F77696E67>10 <20>-9 <65>4 <7665>4 <6E74>-11 <733A>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 468.22 585.82 Td <20>Tj ET EMC Q /P <</MCID 17 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 572.02 Td <20>Tj ET EMC Q /P <</MCID 18 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 557.23 Td [<50>-3 <2E20416464697469>-3 <6F6E206F66>3 <20474D50206F6E2074>5 <6865>4 <2035>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 238.13 557.23 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 241.13 557.23 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 244.13 557.23 Td [<65>4 <6E64>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 261.53 557.23 Td <20>Tj ET EMC Q /P <</MCID 19 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 542.59 Td [<512E2052656D6F7661>5 <6C206F6620>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 173.06 542.59 Td <004A>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 177.98 542.59 Td <2D>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 181.97 542.59 Td [<70686F737068>-10 <61>4 <7465206F66>5 <20746865207472>3 <6970686F73>-2 <706861>4 <7465206F6E>-7 <20666972>4 <73742062617365>4 <2061>4 <742074>-3 <6865>4 <2035>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 423.58 542.59 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 426.58 542.59 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 429.58 542.59 Td [<65>4 <6E64>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 446.98 542.59 Td <20>Tj ET EMC Q /P <</MCID 20 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 527.83 Td [<52>-2 <2E2035>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 119.18 527.83 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 122.18 527.83 Td <2D>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 126.14 527.83 Td <35>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 132.14 527.83 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 135.14 527.83 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 138.14 527.83 Td [<6C69>-3 <6E6B61>4 <67>10 <65>4 <206265>4 <74>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 190.97 527.83 Td [<77>-7 <65>4 <65>4 <6E20>-9 <474D5020616E6420746865>3 <20666972>4 <73742062617365>4 <20>-9 <61>4 <742035>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT /C0_0 12 Tf 350.71 527.83 Td <0063>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 353.71 527.83 Td <20>Tj ET Q q 93.39 483.55 452.13 114.01 re W* n BT 356.71 527.83 Td [<65>4 <6E64>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 373.99 527.83 Td <20>Tj ET EMC Q /P <</MCID 21 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 514.15 Td [<53>-3 <2E20416464697469>-3 <6F6E206F66>3 <206D657468>-9 <79>30 <6C20>-11 <6772>-6 <6F757020746F204E3720706F7369>-2 <7469>-3 <6F6E206F66>3 <2067>10 <75>-9 <61>4 <6E696E65>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 360.67 514.15 Td <20>Tj ET EMC Q /P <</MCID 22 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 500.35 Td <20>Tj ET EMC Q /P <</MCID 23 >>BDC q 93.39 483.55 452.13 114.01 re W* n BT 99.144 486.55 Td [<57>-5 <68696368206F6E65>6 <206F6620746865>5 <20666F6C6C6F77696E67>9 <2069732074>-4 <6865>4 <2063>4 <6F>-9 <7272>6 <65>-5 <63>4 <74207365717565>5 <6E>-9 <63>-5 <65>4 <206F662065>7 <7665>4 <6E74733F>]TJ ET Q q 93.39 483.55 452.13 114.01 re W* n BT 395.83 486.55 Td <20>Tj ET EMC Q q 93.39 462.31 212.57 14.04 re W* n /P <</MCID 24 >>BDC q 93.384 462.31 212.57 14.04 re W* n BT 98.784 465.55 Td [<2841>5 <2920502C20512C20522C2053>]TJ ET Q q 93.384 462.31 212.57 14.04 re W* n BT 166.46 465.55 Td <20>Tj ET EMC Q Q q 305.96 462.31 239.57 14.04 re W* n /P <</MCID 25 >>BDC q 305.95 462.31 239.57 14.04 re W* n BT 311.35 465.55 Td [<2842>10 <2920502C2052>-3 <2C20512C2053>]TJ ET Q q 305.95 462.31 239.57 14.04 re W* n BT 378.31 465.55 Td <20>Tj ET EMC Q Q q 93.39 445.75 212.57 16.56 re W* n /P <</MCID 26 >>BDC q 93.384 445.75 212.57 16.56 re W* n BT 98.784 451.51 Td [<2843292051>5 <2C2050>-3 <2C2052>-2 <2C2053>]TJ ET Q q 93.384 445.75 212.57 16.56 re W* n BT 165.74 451.51 Td <20>Tj ET EMC Q Q q 305.96 445.75 239.57 16.56 re W* n /P <</MCID 27 >>BDC q 305.95 445.75 239.57 16.56 re W* n BT 311.35 451.51 Td [<2844>5 <292051>5 <2C2050>-3 <2C2053>-3 <2C2052>]TJ ET Q q 305.95 445.75 239.57 16.56 re W* n BT 379.03 451.51 Td <20>Tj ET EMC Q Q BT /P <</MCID 28 >>BDC 54 434.95 Td <20>Tj EMC /P <</MCID 29 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 357.28 33.99 60.87 re W* n /P <</MCID 30 >>BDC q 59.4 357.29 33.984 60.864 re W* n BT 64.824 407.35 Td <512E3431>Tj ET Q q 59.4 357.29 33.984 60.864 re W* n BT /TT1 12 Tf 88.464 407.35 Td ( )Tj ET Q q 59.4 357.29 33.984 60.864 re W* n BT 100.82 407.35 Td ( )Tj ET EMC Q Q /P <</MCID 31 >>BDC q 93.39 357.29 452.13 60.864 re W* n BT 99.144 407.35 Td [(C)-2 (a)4 (lcula)4 (te the)4 ( followin)-10 (g)10 ( int)-3 (e)4 (g)10 (r)-6 (a)4 (l )]TJ ET Q q 93.39 357.29 452.13 60.864 re W* n BT 254.33 407.35 Td [(\(up to two de)-4 (c)4 (im)-3 (a)4 (l pl)-3 (a)4 (c)4 (e)4 (s\))]TJ ET Q q 93.39 357.29 452.13 60.864 re W* n BT 381.67 407.35 Td ( )Tj ET EMC Q /P <</MCID 32 >>BDC q 93.39 357.28 452.13 60.87 re W* n BT 319.39 393.55 Td ( )Tj ET EMC Q /P <</MCID 33 >>BDC q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 234.29 375.65 Td <05EC>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 246.29 376.73 Td <123A>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 251.33 376.25 Td <0754>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 260.69 376.25 Td <0D45>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 272.33 376.25 Td <0375>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 278.93 376.73 Td <123B>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 283.97 376.73 Td <123A>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 289.01 376.25 Td <0754>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 298.25 376.25 Td <0D45>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 309.91 376.25 Td <0373>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 316.51 376.73 Td <123B>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 321.55 376.25 Td <07400754>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 12 Tf 338.59 376.25 Td <0D4C>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 8.52 Tf 241.37 383.59 Td <0B35>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT /C2_0 8.52 Tf 238.97 371.21 Td <0B34>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT 347.59 376.25 Td <20>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT 350.59 376.25 Td <5F5F5F5F5F5F5F5F5F>Tj ET Q q 93.39 357.28 452.13 60.87 re W* n BT 404.59 376.25 Td <20>Tj ET EMC Q /P <</MCID 34 >>BDC q 93.39 357.28 452.13 60.87 re W* n BT 319.39 360.29 Td <20>Tj ET EMC Q BT /P <</MCID 35 >>BDC 54 339.29 Td <20>Tj EMC /P <</MCID 36 >>BDC 0 -13.8 Td <20>Tj EMC ET q 59.4 223.36 33.99 99.12 re W* n /P <</MCID 37 >>BDC q 59.4 223.37 33.984 99.12 re W* n BT 64.824 311.69 Td <512E3432>Tj ET Q q 59.4 223.37 33.984 99.12 re W* n BT /TT1 12 Tf 88.464 311.69 Td ( )Tj ET Q q 59.4 223.37 33.984 99.12 re W* n BT 100.82 311.69 Td ( )Tj ET EMC Q Q /P <</MCID 38 >>BDC q 93.39 223.37 452.13 99.117 re W* n BT 99.144 311.33 Td [(The)5 ( prob)3 (a)4 (bil)-3 (it)-13 (y)20 ( dist)-4 (ributi)-2 (on fo)3 (r a)7 ( )]TJ ET Q q 93.39 223.37 452.13 99.117 re W* n BT 259.97 311.33 Td [(discr)-5 (e)4 (te r)-4 (a)4 (ndom var)5 (iable)4 ( )]TJ ET Q q 93.39 223.37 452.13 99.117 re W* n BT /C2_0 12 Tf 381.67 311.33 Td <073A>Tj ET Q q 93.39 223.37 452.13 99.117 re W* n BT 389.71 311.33 Td <20>Tj ET Q q 93.39 223.37 452.13 99.117 re W* n BT 392.71 311.33 Td [<69732067>7 <6976656E206265>6 <6C6F772E>]TJ ET Q q 93.39 223.37 452.13 99.117 re W* n BT 465.7 311.33 Td <20>Tj ET EMC Q /P <</MCID 39 >>BDC q 93.39 223.36 452.13 99.12 re W* n BT 99.144 297.65 Td <20>Tj ET EMC Q q 247.85 280.13 35.16 14.04 re W* n /P <</MCID 40 >>BDC q 247.85 280.13 35.16 14.04 re W* n BT /C2_0 12 Tf 261.41 282.77 Td <073A>Tj ET Q q 247.85 280.13 35.16 14.04 re W* n BT 269.45 282.77 Td <20>Tj ET EMC Q Q q 283.49 280.13 26.55 14.04 re W* n /P <</MCID 41 >>BDC q 283.49 280.13 26.544 14.04 re W* n BT /C2_0 12 Tf 293.45 282.77 Td <0373>Tj ET Q q 283.49 280.13 26.544 14.04 re W* n BT 300.07 282.77 Td <20>Tj ET EMC Q Q q 310.52 280.13 26.52 14.04 re W* n /P <</MCID 42 >>BDC q 310.51 280.13 26.52 14.04 re W* n BT /C2_0 12 Tf 320.47 282.77 Td <0374>Tj ET Q q 310.51 280.13 26.52 14.04 re W* n BT 327.07 282.77 Td <20>Tj ET EMC Q Q q 337.52 280.13 26.52 14.04 re W* n /P <</MCID 43 >>BDC q 337.51 280.13 26.52 14.04 re W* n BT /C2_0 12 Tf 347.47 282.77 Td <0375>Tj ET Q q 337.51 280.13 26.52 14.04 re W* n BT 354.07 282.77 Td <20>Tj ET EMC Q Q q 364.52 280.13 26.52 14.04 re W* n /P <</MCID 44 >>BDC q 364.51 280.13 26.52 14.04 re W* n BT /C2_0 12 Tf 374.47 282.77 Td <0376>Tj ET Q q 364.51 280.13 26.52 14.04 re W* n BT 381.07 282.77 Td <20>Tj ET EMC Q Q /P <</MCID 45 >>BDC 247.37 294.17 0.48 0.48 re f* 247.37 294.17 0.48 0.48 re f* 247.85 294.17 35.16 0.48 re f* 283.01 294.17 0.48 0.48 re f* 283.49 294.17 26.544 0.48 re f* 310.03 294.17 0.48 0.48 re f* 310.51 294.17 26.52 0.48 re f* 337.03 294.17 0.48 0.48 re f* 337.51 294.17 26.52 0.48 re f* 364.03 294.17 0.48 0.48 re f* 364.51 294.17 26.52 0.48 re f* 391.03 294.17 0.48 0.48 re f* 391.03 294.17 0.48 0.48 re f* 247.37 280.13 0.48 14.04 re f* 283.01 280.13 0.48 14.04 re f* 310.03 280.13 0.48 14.04 re f* 337.03 280.13 0.48 14.04 re f* 364.03 280.13 0.48 14.04 re f* 391.03 280.13 0.48 14.04 re f* EMC q 247.85 265.48 35.16 14.04 re W* n /P <</MCID 46 >>BDC q 247.85 265.49 35.16 14.04 re W* n BT /C2_0 12 Tf 253.01 268.25 Td <0732>Tj ET Q q 247.85 265.49 35.16 14.04 re W* n BT /C2_0 12 Tf 260.69 268.25 Td <123A>Tj ET Q q 247.85 265.49 35.16 14.04 re W* n BT /C2_0 12 Tf 265.73 268.25 Td <073A>Tj ET Q q 247.85 265.49 35.16 14.04 re W* n BT /C2_0 12 Tf 273.77 268.25 Td <123B>Tj ET Q q 247.85 265.49 35.16 14.04 re W* n BT 278.69 268.25 Td <20>Tj ET EMC Q Q q 283.49 265.48 26.55 14.04 re W* n /P <</MCID 47 >>BDC q 283.49 265.49 26.544 14.04 re W* n BT /C2_0 12 Tf 288.89 268.13 Td <0372>Tj ET Q q 283.49 265.49 26.544 14.04 re W* n BT /C2_0 12 Tf 295.49 268.13 Td <01E4>Tj ET Q q 283.49 265.49 26.544 14.04 re W* n BT /C2_0 12 Tf 298.01 268.13 Td <0375>Tj ET Q q 283.49 265.49 26.544 14.04 re W* n BT 304.63 268.13 Td <20>Tj ET EMC Q Q q 310.52 265.48 26.52 14.04 re W* n /P <</MCID 48 >>BDC q 310.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 315.91 268.13 Td <0372>Tj ET Q q 310.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 322.51 268.13 Td <01E4>Tj ET Q q 310.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 325.03 268.13 Td <0376>Tj ET Q q 310.51 265.49 26.52 14.04 re W* n BT 331.63 268.13 Td <20>Tj ET EMC Q Q q 337.52 265.48 26.52 14.04 re W* n /P <</MCID 49 >>BDC q 337.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 342.91 268.13 Td <0372>Tj ET Q q 337.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 349.51 268.13 Td <01E4>Tj ET Q q 337.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 352.03 268.13 Td <0374>Tj ET Q q 337.51 265.49 26.52 14.04 re W* n BT 358.63 268.13 Td <20>Tj ET EMC Q Q q 364.52 265.48 26.52 14.04 re W* n /P <</MCID 50 >>BDC q 364.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 369.91 268.13 Td <0372>Tj ET Q q 364.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 376.51 268.13 Td <01E4>Tj ET Q q 364.51 265.49 26.52 14.04 re W* n BT /C2_0 12 Tf 379.03 268.13 Td <0373>Tj ET Q q 364.51 265.49 26.52 14.04 re W* n BT 385.63 268.13 Td <20>Tj ET EMC Q Q /P <</MCID 51 >>BDC 247.37 279.65 0.48 0.48 re f* 247.85 279.65 35.16 0.48 re f* 283.01 279.65 0.48 0.48 re f* 283.49 279.65 26.544 0.48 re f* 310.03 279.65 0.48 0.48 re f* 310.51 279.65 26.52 0.48 re f* 337.03 279.65 0.48 0.48 re f* 337.51 279.65 26.52 0.48 re f* 364.03 279.65 0.48 0.48 re f* 364.51 279.65 26.52 0.48 re f* 391.03 279.65 0.48 0.48 re f* 247.37 265.49 0.48 14.16 re f* 247.37 265.01 0.48 0.48 re f* 247.37 265.01 0.48 0.48 re f* 247.85 265.01 35.16 0.48 re f* 283.01 265.49 0.48 14.16 re f* 283.01 265.01 0.48 0.48 re f* 283.49 265.01 26.544 0.48 re f* 310.03 265.49 0.48 14.16 re f* 310.03 265.01 0.48 0.48 re f* 310.51 265.01 26.52 0.48 re f* 337.03 265.49 0.48 14.16 re f* 337.03 265.01 0.48 0.48 re f* 337.51 265.01 26.52 0.48 re f* 364.03 265.49 0.48 14.16 re f* 364.03 265.01 0.48 0.48 re f* 364.51 265.01 26.52 0.48 re f* 391.03 265.49 0.48 14.16 re f* 391.03 265.01 0.48 0.48 re f* 391.03 265.01 0.48 0.48 re f* EMC /P <</MCID 52 >>BDC q 93.39 223.36 452.13 99.12 re W* n BT 99.144 254.21 Td <20>Tj ET EMC Q /P <</MCID 53 >>BDC q 93.39 223.36 452.13 99.12 re W* n BT 99.144 240.05 Td [<546865>5 <2065>4 <78>-9 <7065>4 <63>4 <746174696F6E2076616C7565>4 <206F6620>]TJ ET Q q 93.39 223.36 452.13 99.12 re W* n BT /C2_0 12 Tf 221.09 240.05 Td <073A>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 229.13 240.05 Td <20>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 232.13 240.05 Td <697320>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 243.17 240.05 Td <28757020746F20>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 274.49 240.05 Td <6F>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 280.49 240.05 Td <6E65>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 291.77 240.05 Td <20>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 294.77 240.05 Td [<6465>4 <63>4 <696D>-3 <61>4 <6C20706C>-3 <61>-5 <63>4 <65>]TJ ET Q q 93.39 223.36 452.13 99.12 re W* n BT 361.03 240.05 Td <29>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 364.99 240.05 Td <20>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 367.99 240.05 Td <5F5F5F5F5F5F5F5F5F>Tj ET Q q 93.39 223.36 452.13 99.12 re W* n BT 422.14 240.05 Td <20>Tj ET EMC Q /P <</MCID 54 >>BDC q 93.39 223.36 452.13 99.12 re W* n BT 99.144 226.37 Td <20>Tj ET EMC Q BT /P <</MCID 55 >>BDC 54 205.37 Td <20>Tj EMC /P <</MCID 56 >>BDC 0 -13.83 Td <20>Tj EMC ET q 59.4 146.31 33.99 42.24 re W* n /P <</MCID 57 >>BDC q 59.4 146.3 33.984 42.24 re W* n BT 64.824 177.74 Td <512E3433>Tj ET Q q 59.4 146.3 33.984 42.24 re W* n BT /TT1 12 Tf 88.464 177.74 Td ( )Tj ET Q q 59.4 146.3 33.984 42.24 re W* n BT 100.82 177.74 Td ( )Tj ET EMC Q Q /P <</MCID 58 >>BDC q 93.39 146.31 452.13 42.234 re W* n BT 99.144 177.26 Td [(I)13 (f)-6 ( )]TJ ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 110.18 177.26 Td <0373>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 119.42 177.26 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 131.06 177.26 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 137.06 177.26 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 142.34 177.26 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 152.66 177.26 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 156.62 177.26 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 8.52 Tf 162.98 181.7 Td <0B36>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 171.02 177.26 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 181.37 177.26 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 185.33 177.26 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 8.52 Tf 191.69 181.7 Td <0B37>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 199.73 177.26 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 211.37 177.26 Td <06AE>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 223.61 177.26 Td <03BB>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 233.81 177.26 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 239.81 177.26 Td <0D4C>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 252.05 177.26 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 254.69 177.26 Td <0373>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 261.41 177.26 Td <01E4>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT /C2_0 12 Tf 263.93 177.26 Td <0377>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT 270.53 177.26 Td <2C20>Tj ET Q q 93.39 146.31 452.13 42.234 re W* n BT 276.53 177.26 Td <20>Tj ET EMC Q /P <</MCID 59 >>BDC q 93.39 146.31 452.13 42.24 re W* n BT 99.144 163.1 Td <7468656E2C20>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 125.78 163.1 Td <0373>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 132.5 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 137.78 163.1 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 149.42 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 152.06 163.1 Td <0374>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 158.66 163.1 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 164.66 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 169.94 163.1 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 181.61 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 184.25 163.1 Td <0375>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 190.85 163.1 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 8.52 Tf 197.21 167.54 Td <0B36>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 203.93 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 207.89 163.1 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 219.53 163.1 Td <0003>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 222.17 163.1 Td <0376>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 228.89 163.1 Td <074E>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 8.52 Tf 235.25 167.54 Td <0B37>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 243.17 163.1 Td <0D45>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 254.81 163.1 Td <06AE>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 267.17 163.1 Td <03BB>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT /C2_0 12 Tf 280.61 163.1 Td <0D4C>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT 289.61 163.1 Td <20>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT 292.61 163.1 Td [<28757020746F2074776F206465>5 <63>4 <696D>-3 <61>4 <6C>-11 <20706C6163>6 <65>4 <7329>]TJ ET Q q 93.39 146.31 452.13 42.24 re W* n BT 419.86 163.1 Td <20>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT 422.86 163.1 Td <5F5F5F5F5F5F5F5F5F>Tj ET Q q 93.39 146.31 452.13 42.24 re W* n BT 476.98 163.1 Td <20>Tj ET EMC Q /P <</MCID 60 >>BDC q 93.39 146.31 452.13 42.24 re W* n BT 99.144 149.3 Td <20>Tj ET EMC Q BT /P <</MCID 61 >>BDC 54 128.3 Td <20>Tj EMC /P <</MCID 62 >>BDC 0 -13.8 Td <20>Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 522.82 37.704 Td (10)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT -0.06 Tc 533.14 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q q 59.4 629.73 33.99 157.95 re W* n /P <</MCID 0 >>BDC q 59.4 629.74 33.984 157.94 re W* n BT /TT0 12 Tf 64.824 776.88 Td (Q.44)Tj ET Q q 59.4 629.74 33.984 157.94 re W* n BT /TT1 12 Tf 88.464 776.88 Td ( )Tj ET Q q 59.4 629.74 33.984 157.94 re W* n BT /TT0 12 Tf 100.82 776.88 Td ( )Tj ET EMC Q Q /P <</MCID 1 >>BDC q 93.39 629.74 452.13 157.94 re W* n BT /TT0 12 Tf 99.144 776.88 Td [(Mois)-3 (t )8 (he)4 (a)4 (t )8 (ster)4 (il)-3 (iz)-7 (a)4 (ti)-3 (on )10 (of )13 (spore)6 (s)-10 ( )10 (a)4 (t )8 (121)-9 ( )]TJ ET Q q 93.39 629.74 452.13 157.94 re W* n BT 291.53 781.44 Td (o)Tj ET Q q 93.39 629.74 452.13 157.94 re W* n BT /TT0 12 Tf 295.49 776.88 Td [(C)-2 ( follows )10 (fir)4 (st )7 (ord)-6 (e)4 (r )13 (kin)-11 (e)4 (ti)-3 (c)4 (s )9 (a)4 (s)-10 ( )10 (pe)-5 (r )13 (the e)6 (x)-9 (pre)7 (ssi)-3 (on:)]TJ ET Q q 93.39 629.74 452.13 157.94 re W* n BT /TT0 12 Tf 539.76 776.88 Td ( )Tj ET EMC Q /P <</MCID 2 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /TT0 12 Tf 99.144 763.08 Td ( )Tj ET EMC Q /P <</MCID 3 >>BDC q 0.83542 0 0 0.42639 289.36 729.42 cm /GS0 gs /TT0 8.04 Tf 0 TL/Fm0 Do Q EMC /P <</MCID 4 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS1 gs /TT0 12 Tf 349.51 741.46 Td ( )Tj ET EMC Q /P <</MCID 5 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 99.144 718.54 Td ( )Tj ET EMC Q /P <</MCID 6 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 99.144 704.74 Td [(whe)6 (re)7 (, )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 12 Tf 137.78 704.74 Td (N)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 145.82 704.74 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 152.3 704.74 Td [(is )-292 (the )-287 (numbe)-7 (r )-286 (of )-286 (viable)4 ( )-289 (spor)-7 (e)4 (s, )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 12 Tf 323.59 704.74 Td (t)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 326.95 704.74 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 333.43 704.74 Td [(is )-292 (the )-287 (ti)-3 (me, )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 12 Tf 399.91 704.74 Td (k)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 8.04 Tf 405.19 703.78 Td (d)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 409.27 704.74 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 415.75 704.74 Td [(is )-292 (the )-287 (r)]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 455.38 704.74 Td [(a)4 (te )-287 (c)4 (onst)-2 (a)4 (nt )-291 (a)4 (n)-9 (d)-9 ( )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 542.76 704.74 Td [( )-9 ( )]TJ ET EMC Q /P <</MCID 7 >>BDC q 0.29514 0 0 0.42639 99.16 671.12 cm /GS0 gs /TT0 8.04 Tf 0 TL/Fm1 Do Q EMC /P <</MCID 8 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS1 gs /TT0 12 Tf 120.38 683.14 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 123.38 683.14 Td [(is t)-4 (he)4 ( ra)7 (te of)5 ( c)4 (h)-9 (a)4 (n)-9 (g)10 (e)4 ( o)-9 (f v)-6 (iable)4 ( spore)6 (s.)]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 302.11 683.14 Td ( )Tj ET EMC Q /P <</MCID 9 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 99.144 660.34 Td [(I)13 (f)-6 ( )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 12 Tf 110.06 660.34 Td (k)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT2 8.04 Tf 115.34 659.38 Td (d)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 119.42 660.34 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 122.42 660.34 Td [(v)-9 (a)4 (lue is)-10 ( 1.0 mi)-3 (n)]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs 199.37 664.9 Td (-)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs 202.01 664.9 Td (1)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 206.09 660.34 Td [(, th)-11 (e)4 ( ti)-3 (me \()5 (in)-11 ( mi)-3 (nutes\))4 ( )-9 (re)7 (qui)-11 (re)7 (d to )-11 (re)7 (du)-9 (c)4 (e)4 ( th)-11 (e)4 ( numbe)-7 (r)-6 ( of via)5 (bl)-11 (e)4 ( spor)-7 (e)4 (s)9 ( )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 99.144 646.54 Td [(fr)6 (om an init)-3 (ial va)4 (lue of)5 ( 1)-9 (0)]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs 0.06 Tc 224.81 651.1 Td (10)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 232.97 646.54 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 235.85 646.54 Td [(to a f)5 (inal va)4 (lue of)5 ( 1 is)-12 ( )]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 343.51 646.54 Td [(\(up to two de)5 (c)4 (im)-3 (a)4 (l pl)-3 (a)4 (c)-5 (e)-5 (s\))]TJ ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 470.86 646.54 Td ( )Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 473.86 646.54 Td (_________)Tj ET Q q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 527.86 646.54 Td ( )Tj ET EMC Q /P <</MCID 10 >>BDC q 93.39 629.73 452.13 157.95 re W* n BT /GS0 gs /TT0 12 Tf 99.144 632.74 Td ( )Tj ET EMC Q BT /P <</MCID 11 >>BDC /GS0 gs /TT0 12 Tf 54 611.74 Td ( )Tj EMC /P <</MCID 12 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 539.71 33.99 55.215 re W* n /P <</MCID 13 >>BDC q 59.4 539.71 33.984 55.224 re W* n BT 64.824 584.14 Td (Q.45)Tj ET Q q 59.4 539.71 33.984 55.224 re W* n BT /TT1 12 Tf 88.464 584.14 Td ( )Tj ET Q q 59.4 539.71 33.984 55.224 re W* n BT 100.82 584.14 Td ( )Tj ET EMC Q Q /P <</MCID 14 >>BDC q 93.39 539.71 452.13 55.215 re W* n BT 99.144 584.14 Td [(An )-37 (a)4 (que)4 (ous )-40 (solut)-4 (ion )-41 (c)4 (on)10 (taining)8 ( )-39 (6.8 )-39 (mg)8 (/)-11 (L)21 ( )-39 (of )-36 (a)4 (n )-39 (a)-5 (nti)-3 (biot)-3 (ic )-37 (is)7 ( )-39 (e)4 (xtra)5 (c)4 (ted )-37 (with )-41 (a)4 (m)-11 (y)20 (l )-41 (a)4 (c)4 (e)4 (tat)-9 (e)4 (. )-49 (I)13 (f)-6 ( )]TJ ET Q q 93.39 539.71 452.13 55.215 re W* n BT 99.144 570.34 Td [(the )-37 (pa)4 (rtiti)-4 (on )-39 (c)4 (oe)-5 (ff)6 (icie)4 (nt )-51 (of )-36 (the )-37 (a)4 (nti)-3 (biot)-3 (ic )-37 (is )-42 (170 )-49 (a)-5 (nd )-39 (the )-37 (ra)7 (ti)-3 (o )-39 (o)-9 (f )-36 (wa)6 (t)-11 (e)4 (r )-36 (to )-41 (s)-10 (olvent )-39 (is )-42 (85, )-39 (then )]TJ ET Q q 93.39 539.71 452.13 55.215 re W* n BT 99.144 556.51 Td [(the e)6 (x)-9 (tra)5 (c)4 (ti)-3 (on fa)7 (c)4 (tor is )]TJ ET Q q 93.39 539.71 452.13 55.215 re W* n BT 209.69 556.51 Td [(__)-9 (_______)]TJ ET Q q 93.39 539.71 452.13 55.215 re W* n BT 263.81 556.51 Td ( )Tj ET EMC Q /P <</MCID 15 >>BDC q 93.39 539.71 452.13 55.215 re W* n BT 99.144 542.71 Td ( )Tj ET EMC Q BT /P <</MCID 16 >>BDC 54 521.71 Td ( )Tj EMC /P <</MCID 17 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 422.11 33.99 82.8 re W* n /P <</MCID 18 >>BDC q 59.4 422.11 33.984 82.8 re W* n BT 64.824 494.11 Td (Q.46)Tj ET Q q 59.4 422.11 33.984 82.8 re W* n BT /TT1 12 Tf 88.464 494.11 Td ( )Tj ET Q q 59.4 422.11 33.984 82.8 re W* n BT 100.82 494.11 Td ( )Tj ET EMC Q Q /P <</MCID 19 >>BDC q 93.39 422.11 452.13 82.797 re W* n BT 99.144 494.11 Td [(A )-267 (mi)-3 (c)4 (robia)5 (l )-271 (stra)4 (in )-271 (is )-272 (c)-5 (ult)-3 (ure)7 (d )-269 (in )-271 (a)4 ( )-269 (100 )-279 (L)11 ( )-269 (sti)-4 (r)-6 (re)7 (d )-269 (f)-6 (e)4 (rme)5 (nte)-7 (r )-266 (for)6 ( )-269 (s)-10 (e)4 (c)4 (on)-9 (da)4 (r)-16 (y)20 ( )-269 (meta)4 (boli)-3 (te)-7 ( )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 99.144 480.31 Td [(produ)3 (c)4 (ti)-3 (on. )-59 (I)13 (f )-46 (the)-7 ( )-49 (spe)3 (c)4 (ifi)-10 (c)4 ( )-49 (ra)7 (te)-7 ( )-49 (of )-46 (ox)-19 (y)20 (ge)-5 (n )-49 (uptake)-3 ( )-49 (is )-52 (0.4 )-49 (h)]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT0 8.04 Tf 374.59 484.87 Td (-)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT0 8.04 Tf 377.23 484.87 Td (1)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 381.31 480.31 Td ( )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 384.91 480.31 Td [(a)4 (nd )-49 (the )-47 (ox)-19 (y)20 (ge)4 (n)-9 ( )-59 (solub)-2 (il)-3 (it)-13 (y)30 ( )-49 (in )-51 (the)-7 ( )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 99.144 466.51 Td [(broth )-178 (is )-182 (8 )-179 (mg)8 (/)-11 (L)11 (, )-179 (then)-7 ( )-179 (the )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 233.81 466.51 Td [(volum)-3 (e)4 (tric)3 ( )-179 (mass )-179 (tr)-8 (a)4 (n)-9 (sfe)6 (r )-176 (c)4 (o)-9 (e)4 (ff)6 (i)-11 (c)4 (ient)]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 413.35 466.51 Td ( )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 418.54 466.51 Td (\()Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT2 12 Tf 422.5 466.51 Td (K)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT2 8.04 Tf 430.54 465.55 Td (L)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT2 12 Tf 434.98 466.51 Td (a)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 440.98 466.51 Td (\))Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 444.94 466.51 Td ( )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 450.22 466.51 Td [(\(in )-178 (s)]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT0 8.04 Tf 473.38 471.07 Td (-)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT /TT0 8.04 Tf 476.02 471.07 Td (1)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT -0.036 Tc 480.1 466.51 Td (\) )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 489.22 466.51 Td [(of )-176 (ox)-19 (y)20 (ge)4 (n)-9 ( )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 99.144 452.71 Td [(re)7 (quire)5 (d )-289 (to )-291 (a)4 (c)4 (hieve)6 ( )-289 (a)4 ( )-299 (max)-7 (im)-3 (um)8 ( )-289 (c)4 (e)4 (ll)-3 ( )-289 (c)4 (onc)4 (e)4 (ntra)5 (ti)-3 (on )-289 (of )-286 (12 )-289 (g)10 (/)-11 (L)21 ( )-289 (is )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 439.18 452.71 Td [(\(up )-286 (to )-291 (two )-289 (de)4 (c)4 (im)-3 (a)4 (l)8 ( )]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 542.76 452.71 Td ( )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 99.144 438.91 Td [(plac)6 (e)4 (s\))]TJ ET Q q 93.39 422.11 452.13 82.797 re W* n BT 132.98 438.91 Td ( )Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 135.98 438.91 Td (_________)Tj ET Q q 93.39 422.11 452.13 82.797 re W* n BT 190.13 438.91 Td ( )Tj ET EMC Q /P <</MCID 20 >>BDC q 93.39 422.11 452.13 82.8 re W* n BT 99.144 425.11 Td ( )Tj ET EMC Q BT /P <</MCID 21 >>BDC 54 404.11 Td ( )Tj EMC /P <</MCID 22 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 318.28 33.99 69.03 re W* n /P <</MCID 23 >>BDC q 59.4 318.29 33.984 69.024 re W* n BT 64.824 376.49 Td (Q.47)Tj ET Q q 59.4 318.29 33.984 69.024 re W* n BT /TT1 12 Tf 88.464 376.49 Td ( )Tj ET Q q 59.4 318.29 33.984 69.024 re W* n BT 100.82 376.49 Td ( )Tj ET EMC Q Q /P <</MCID 24 >>BDC q 93.39 318.29 452.13 69.024 re W* n BT 99.144 376.49 Td [(I)13 (n )-29 (a)4 ( )-39 (c)4 (he)4 (most)-4 (a)4 (t, )-31 (the )-27 (fe)-2 (e)4 (d )-29 (flow)3 ( )-29 (ra)7 (te )-27 (a)4 (nd )-29 (c)4 (ult)-3 (ur)-6 (e)4 ( )-29 (volum)-3 (e)4 ( )-29 (a)4 (re)7 ( )-29 (100 )-29 (ml)-3 (/h )-31 (a)4 (nd )-29 (1.0 )-39 (L)21 (, )-29 (re)7 (sp)-10 (e)4 (c)4 (ti)-3 (ve)4 (l)-21 (y)20 (.)-9 ( )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 99.144 362.69 Td [(W)-5 (it)-3 (h )10 (g)10 (lucose)5 ( )10 (a)4 (s )9 (subst)-3 (ra)7 (t)]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 215.69 362.69 Td [(e)-5 (, )10 (the )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 244.49 362.69 Td [(va)4 (lues )11 (of )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT2 12 Tf 290.81 362.69 Td (\265)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT2 8.04 Tf 297.77 361.73 Td [(m)5.995 (a)-5.995 (x)]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 311.23 362.69 Td ( )Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 314.11 362.69 Td [(a)4 (nd )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT2 12 Tf 334.27 362.69 Td (K)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT2 8.04 Tf 342.31 361.73 Td (s)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 345.43 362.69 Td ( )Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 348.31 362.69 Td [(a)4 (re)7 ( )10 (0.2 )10 (h)]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT0 8.04 Tf 389.59 367.25 Td (-)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT /TT0 8.04 Tf 392.23 367.25 Td (1)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 396.31 362.69 Td ( )Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 399.19 362.69 Td [(a)4 (nd )10 (1 g)10 (/)-11 (L)11 (, re)7 (s)-10 (pe)4 (c)4 (ti)-3 (ve)4 (l)-21 (y)20 (. )10 (F)6 (o)-9 (r )13 (a)-5 ( )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 99.144 348.89 Td [(g)10 (lucose)-4 ( )-119 (c)4 (on)-9 (c)4 (e)4 (ntr)-8 (a)4 (ti)-3 (on )-119 (of)-6 ( )-119 (10 )-129 (g)10 (/)-11 (L)11 ( )-119 (in )-121 (th)-11 (e)4 ( )-119 (f)-6 (e)4 (e)4 (d, )-119 (th)-11 (e)4 ( )-129 (e)4 (ff)6 (luent )-119 (subst)-3 (r)-6 (a)4 (te )-127 (c)4 (onc)4 (e)-5 (ntra)5 (ti)-3 (on )-119 (\(in )-128 (g)10 (/)-11 (L)11 (\))-6 ( )]TJ ET Q q 93.39 318.29 452.13 69.024 re W* n BT 542.76 348.89 Td ( )Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 99.144 335.09 Td (is )Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 110.18 335.09 Td (_________)Tj ET Q q 93.39 318.29 452.13 69.024 re W* n BT 164.18 335.09 Td ( )Tj ET EMC Q /P <</MCID 25 >>BDC q 93.39 318.28 452.13 69.03 re W* n BT 99.144 321.29 Td ( )Tj ET EMC Q BT /P <</MCID 26 >>BDC 54 300.29 Td ( )Tj EMC /P <</MCID 27 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 226.48 33.99 57 re W* n /P <</MCID 28 >>BDC q 59.4 226.49 33.984 57 re W* n BT 64.824 272.69 Td (Q.48)Tj ET Q q 59.4 226.49 33.984 57 re W* n BT /TT1 12 Tf 88.464 272.69 Td ( )Tj ET Q q 59.4 226.49 33.984 57 re W* n BT 100.82 272.69 Td ( )Tj ET EMC Q Q /P <</MCID 29 >>BDC q 93.39 226.49 452.13 56.997 re W* n BT 99.144 271.73 Td [(Ma)3 (mm)-3 (a)4 (li)-3 (a)4 (n )-69 (c)4 (e)4 (ll)-3 (s )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 186.77 271.73 Td [(in )-71 (a)4 (c)4 (ti)6 (ve)4 ( )-69 (g)10 (row)5 (th )-71 (pha)4 (s)-10 (e)4 ( )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 301.15 271.73 Td [(we)6 (re)7 ( )-69 (se)-6 (e)4 (de)4 (d )-69 (a)4 (t )-71 (a)4 ( )-69 (de)4 (nsit)-14 (y)20 ( )-69 (of)]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 434.62 271.73 Td ( )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 438.46 271.73 Td (1)Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT /C0_0 12 Tf 444.46 271.73 Td <0075>Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 451.06 271.73 Td <3130>Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT /TT0 8.04 Tf 0.06 Tc 463.06 276.29 Td (5 )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 469.66 271.73 Td [(c)4 (e)4 (ll)-3 (s/m)-4 (l. )-71 (Af)5 (ter)5 ( )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 542.76 271.73 Td ( )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 99.144 256.97 Td [(72 )-39 (hours, )-37 (1)]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT /C0_0 12 Tf 153.74 256.97 Td <0075>Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 160.34 256.97 Td <3130>Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT /TT0 8.04 Tf 172.34 261.53 Td (6)Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 176.3 256.97 Td ( )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 179.81 256.97 Td [(c)4 (e)4 (ll)-3 (s/m)-4 (l )-31 (we)6 (re)7 ( )-39 (obtaine)4 (d. )-39 (The)5 ( )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 317.71 256.97 Td [(popu)-9 (lation )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 372.67 256.97 Td [(doubli)-3 (ng)10 ( )-39 (ti)-3 (me )-37 (of )-36 (t)8 (he)4 ( )-39 (c)4 (e)4 (ll)-3 (s )-40 (in )-41 (hour)13 (s)9 ( )]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 99.144 243.29 Td (is )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 110.18 243.29 Td [(\(up to two de)5 (c)4 (im)-3 (a)4 (l pl)-3 (a)-5 (c)4 (e)4 (s\))]TJ ET Q q 93.39 226.49 452.13 56.997 re W* n BT 237.41 243.29 Td ( )Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 240.41 243.29 Td (_________)Tj ET Q q 93.39 226.49 452.13 56.997 re W* n BT 294.53 243.29 Td ( )Tj ET EMC Q /P <</MCID 30 >>BDC q 93.39 226.48 452.13 57 re W* n BT 99.144 229.49 Td ( )Tj ET EMC Q BT /P <</MCID 31 >>BDC 54 208.49 Td ( )Tj EMC /P <</MCID 32 >>BDC 0 -13.83 Td ( )Tj EMC ET q 59.4 80.31 33.99 111.36 re W* n /P <</MCID 33 >>BDC q 59.4 80.304 33.984 111.36 re W* n BT 64.824 180.86 Td (Q.49)Tj ET Q q 59.4 80.304 33.984 111.36 re W* n BT /TT1 12 Tf 88.464 180.86 Td ( )Tj ET Q q 59.4 80.304 33.984 111.36 re W* n BT 100.82 180.86 Td ( )Tj ET EMC Q Q /P <</MCID 34 >>BDC q 93.39 80.31 452.13 111.35 re W* n BT 99.144 180.86 Td [(Ye)6 (a)4 (st )-122 (c)4 (onv)-9 (e)4 (rt)]TJ ET Q q 93.39 80.31 452.13 111.35 re W* n BT 166.82 180.86 Td (s)Tj ET Q q 93.39 80.31 452.13 111.35 re W* n BT 171.5 180.86 Td ( )Tj ET Q q 93.39 80.31 452.13 111.35 re W* n BT 176.06 180.86 Td [(g)10 (lucose)]TJ ET Q q 93.39 80.31 452.13 111.35 re W* n BT 212.69 180.86 Td ( )Tj ET Q q 93.39 80.31 452.13 111.35 re W* n BT 217.13 180.86 Td [(to )-121 (e)4 (thanol )-119 (a)4 (nd )-129 (c)4 (a)4 (rbon)-6 ( )-119 (diox)-11 (ide )-117 (b)-9 (y)20 ( )-129 (g)10 (l)-11 (y)20 (c)-5 (ol)-21 (y)30 (sis)-3 ( )-129 (a)4 (s )-120 (p)-9 (e)4 (r )-116 (the )-127 (following )]TJ ET Q q 93.39 80.31 452.13 111.35 re W* n BT 99.144 167.06 Td [(re)7 (a)4 (c)4 (ti)-3 (on:)]TJ ET Q q 93.39 80.31 452.13 111.35 re W* n BT 141.14 167.06 Td ( )Tj ET EMC Q /P <</MCID 35 >>BDC q 93.39 80.31 452.13 111.36 re W* n BT 99.144 153.26 Td ( )Tj ET EMC Q /P <</MCID 36 >>BDC q 93.39 80.31 452.13 111.36 re W* n BT 246.05 138.5 Td (C)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 254.09 137.54 Td (6)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 258.17 138.5 Td (H)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf -0.06 Tc 266.81 137.54 Td (12)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 274.85 138.5 Td (O)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 283.37 137.54 Td (6)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 287.45 138.5 Td ( )Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /C0_0 12 Tf 290.45 138.5 Td <006F>Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 302.35 138.5 Td <20>Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 305.35 138.5 Td <3243>Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 319.27 137.54 Td (2)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 323.35 138.5 Td (H)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 331.99 137.54 Td (5)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 336.07 138.5 Td [(OH)4 ( +)4 ( 2C)-2 (O)]TJ ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 388.75 137.54 Td (2)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT /TT0 8.04 Tf 392.71 137.54 Td ( )Tj ET EMC Q /P <</MCID 37 >>BDC q 93.39 80.31 452.13 111.36 re W* n BT 99.144 124.7 Td ( )Tj ET EMC Q /P <</MCID 38 >>BDC q 93.39 80.31 452.13 111.36 re W* n BT 99.144 110.9 Td [(Assumi)-3 (ng)10 ( )50 (c)4 (ompl)-3 (e)4 (t)-11 (e)4 ( )50 (c)4 (onv)-9 (e)4 (rsion, )50 (the )]TJ ET Q q 93.39 80.31 452.13 111.36 re W* n BT 271.85 110.9 Td [(a)4 (mount)-3 ( )50 (of)-6 ( )50 (e)4 (tha)-7 (nol )48 (produ)3 (c)4 (e)4 (d)-9 ( )50 (\(in )41 (g\) )53 (f)-6 (rom )41 (200 )50 (g )50 (of)-6 ( )40 (g)10 (lucose)-4 ( )]TJ ET Q q 93.39 80.31 452.13 111.36 re W* n BT 0.024 Tc 99.144 97.104 Td (is)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 107.18 97.104 Td ( )Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 110.18 97.104 Td [(\(up to two de)5 (c)4 (im)-3 (a)4 (l pl)-3 (a)-5 (c)4 (e)4 (s\))]TJ ET Q q 93.39 80.31 452.13 111.36 re W* n BT 237.41 97.104 Td ( )Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 240.41 97.104 Td (_________)Tj ET Q q 93.39 80.31 452.13 111.36 re W* n BT 294.53 97.104 Td ( )Tj ET EMC Q /P <</MCID 39 >>BDC q 93.39 80.31 452.13 111.36 re W* n BT 99.144 83.304 Td ( )Tj ET EMC Q BT /P <</MCID 40 >>BDC 54 62.304 Td ( )Tj EMC ET /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /GS0 gs /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 522.82 37.704 Td (11)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT -0.06 Tc 533.14 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q BT /P <</MCID 0 >>BDC /TT0 12 Tf 54 776.88 Td ( )Tj EMC ET q 59.4 718.65 33.99 55.23 re W* n /P <</MCID 1 >>BDC q 59.4 718.66 33.984 55.224 re W* n BT 64.824 763.08 Td (Q.50)Tj ET Q q 59.4 718.66 33.984 55.224 re W* n BT /TT1 12 Tf 88.464 763.08 Td ( )Tj ET Q q 59.4 718.66 33.984 55.224 re W* n BT 100.82 763.08 Td ( )Tj ET EMC Q Q /P <</MCID 2 >>BDC q 93.39 718.66 452.13 55.224 re W* n BT 99.144 763.08 Td [(At )-89 (the )-87 (e)4 (nd )-89 (of )-86 (a)4 ( )-89 (ba)4 (tch )-97 (c)4 (u)-9 (lt)-3 (ure)7 (, )-89 (g)10 (lucos)-8 (e)4 ( )-89 (solut)-4 (ion )-91 (is )-92 (a)4 (dde)4 (d )-89 (a)4 (t )-91 (a)4 ( )-89 (flow)3 ( )-99 (ra)7 (te )-87 (of )-96 (200 )-89 (ml)-3 (/h. )-101 (I)23 (f )-86 (the )]TJ ET Q q 93.39 718.66 452.13 55.224 re W* n BT 99.144 749.26 Td (c)Tj ET Q q 93.39 718.66 452.13 55.224 re W* n BT 104.42 749.26 Td [(ult)-3 (ure)7 ( )-69 (volum)-3 (e)4 ( )-69 (a)-5 (fte)5 (r )-66 (2 )-69 (h )-79 (of )-66 (g)10 (lu)-11 (c)4 (ose)3 ( )-69 (a)4 (ddit)-3 (ion )-71 (is )-72 (10)-9 (00 )-69 (ml)-3 (, )-69 (the )-67 (ini)-3 (ti)-3 (a)4 (l )-71 (c)4 (ult)-3 (ure)7 ( )-69 (volum)-3 (e)4 ( )-69 (\(in )-68 (ml)-3 (\) )]TJ ET Q q 93.39 718.66 452.13 55.224 re W* n BT 542.76 749.26 Td ( )Tj ET Q q 93.39 718.66 452.13 55.224 re W* n BT 99.144 735.46 Td (is )Tj ET Q q 93.39 718.66 452.13 55.224 re W* n BT 110.18 735.46 Td (_________)Tj ET Q q 93.39 718.66 452.13 55.224 re W* n BT 164.18 735.46 Td ( )Tj ET EMC Q /P <</MCID 3 >>BDC q 93.39 718.65 452.13 55.23 re W* n BT 99.144 721.66 Td ( )Tj ET EMC Q BT /P <</MCID 4 >>BDC 54 700.66 Td ( )Tj EMC /P <</MCID 5 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 567.33 33.99 116.52 re W* n /P <</MCID 6 >>BDC q 59.4 567.34 33.984 116.52 re W* n BT 64.824 673.06 Td (Q.51)Tj ET Q q 59.4 567.34 33.984 116.52 re W* n BT /TT1 12 Tf 88.464 673.06 Td ( )Tj ET Q q 59.4 567.34 33.984 116.52 re W* n BT 100.82 673.06 Td ( )Tj ET EMC Q Q /P <</MCID 7 >>BDC q 93.39 567.34 452.13 116.51 re W* n BT 99.144 673.06 Td [(C)-2 (onsi)-2 (de)4 (r )]TJ ET Q q 93.39 567.34 452.13 116.51 re W* n BT 145.46 673.06 Td [(the f)5 (oll)-3 (owing)]TJ ET Q q 93.39 567.34 452.13 116.51 re W* n BT 209.69 673.06 Td ( )Tj ET Q q 93.39 567.34 452.13 116.51 re W* n BT 212.81 673.06 Td [(a)4 (li)-3 (g)10 (nment of)3 ( two D)-7 (NA)4 ( se)3 (q)-9 (ue)4 (nc)4 (e)4 (s:)]TJ ET Q q 93.39 567.34 452.13 116.51 re W* n BT 378.79 673.06 Td ( )Tj ET EMC Q /P <</MCID 8 >>BDC q 93.39 567.33 452.13 116.52 re W* n BT /TT2 12 Tf 353.95 622.66 Td ( )Tj ET EMC Q /P <</MCID 9 >>BDC q 93.39 567.33 452.13 116.52 re W* n BT 99.144 611.74 Td [(Assumi)-3 (ng)10 ( )40 (a)4 (n )30 (a)4 (ff)6 (in)-11 (e)4 ( )30 (g)10 (a)4 (p )]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 214.49 611.74 Td [(s)-10 (c)4 (oring )41 (sc)3 (he)4 (m)-11 (e)4 ( )40 (of )33 (a)4 (n )40 (ident)-9 (it)-13 (y)20 ( )40 (matr)3 (ix)-11 ( )40 (for)6 ( )40 (subst)-3 (it)-3 (uti)-3 (on, )40 (a)4 ( )30 (g)10 (a)4 (p )40 (in)]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 505.66 611.74 Td [(it)-3 (iation )]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 99.144 597.94 Td [(pe)4 (na)4 (lt)-13 (y)20 ( )-109 (of)-6 ( )-99 (1 )-109 (a)4 (nd )-99 (a)-5 ( )-109 (g)10 (a)4 (p)-9 ( )-99 (e)-5 (x)-9 (tension )-100 (pe)4 (na)4 (lt)-13 (y)20 ( )-99 (o)-9 (f )-96 (0.1,)-9 ( )-109 (the )-97 (sc)3 (or)-6 (e)4 ( )-99 (of)-6 ( )-99 (the)-7 ( )-99 (a)4 (li)-13 (g)10 (nme)-7 (nt )-101 (is )]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 488.62 597.94 Td [(\(up )-96 (to)-11 ( )]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 522.46 597.94 Td [(one)4 ( )]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 99.144 584.14 Td [(de)4 (c)4 (im)-3 (a)4 (l pl)-3 (a)4 (c)4 (e)]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 165.38 584.14 Td (\))Tj ET Q q 93.39 567.33 452.13 116.52 re W* n BT 169.34 584.14 Td ( )Tj ET Q q 93.39 567.33 452.13 116.52 re W* n BT 172.34 584.14 Td [(________)-9 (_)]TJ ET Q q 93.39 567.33 452.13 116.52 re W* n BT 226.49 584.14 Td ( )Tj ET EMC Q /P <</MCID 10 >>BDC q 93.39 567.33 452.13 116.52 re W* n BT 99.144 570.34 Td ( )Tj ET EMC Q BT /P <</MCID 11 >>BDC 54 549.31 Td ( )Tj EMC /P <</MCID 12 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 491.12 33.99 41.4 re W* n /P <</MCID 13 >>BDC q 59.4 491.11 33.984 41.4 re W* n BT 64.824 521.71 Td (Q.52)Tj ET Q q 59.4 491.11 33.984 41.4 re W* n BT /TT1 12 Tf 88.464 521.71 Td ( )Tj ET Q q 59.4 491.11 33.984 41.4 re W* n BT 100.82 521.71 Td ( )Tj ET EMC Q Q q 93.39 491.12 452.13 41.4 re W* n /P <</MCID 14 >>BDC q 93.384 491.11 452.14 41.4 re W* n BT 99.144 521.71 Td [(F)6 (irst )-301 (orde)7 (r )-296 (d)]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 165.62 521.71 Td [(e)4 (a)4 (c)4 (ti)-3 (va)4 (ti)-3 (on)-9 ( )-299 (ra)7 (te )-297 (c)4 (onst)-2 (a)4 (nts )-302 (for)6 ( )-299 (sol)-12 (uble )-297 (a)4 (nd )-299 (im)-3 (mobi)-3 (li)-3 (z)-5 (e)4 (d )-289 (a)4 (m)-11 (y)20 (lo)-11 (g)10 (lucosida)3 (s)-10 (e)4 ( )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 99.144 507.91 Td [(e)4 (nz)-15 (y)20 (me )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 138.86 507.91 Td [(a)4 (re)-2 ( )50 (0.03)]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 176.9 507.91 Td ( )Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 0.024 Tc 179.3 507.91 Td (min)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT /TT0 8.04 Tf 198.05 512.47 Td (-)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT /TT0 8.04 Tf 200.69 512.47 Td (1)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 204.77 507.91 Td ( )Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 207.17 507.91 Td [(a)4 (n)-9 (d )50 (0.005 )50 (mi)-3 (n)]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT /TT0 8.04 Tf 275.09 512.47 Td (-)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT /TT0 8.04 Tf 277.73 512.47 Td (1)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 281.81 507.91 Td [(, )50 (re)7 (spe)3 (c)4 (ti)-3 (ve)4 (l)-11 (y)20 (.)-9 ( )50 (Th)-8 (e)4 ( )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 371.59 507.91 Td [(r)-6 (a)4 (ti)-3 (o )50 (of )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 408.43 507.91 Td (ha)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 0.144 Tc 419.74 507.91 Td (lf)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 427.18 507.91 Td (-)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 431.14 507.91 Td [(li)-3 (fe)7 ( )50 (o)-9 (f)-6 ( )50 (the )52 (im)-3 (mobi)-3 (li)-3 (z)-5 (e)14 (d)10 ( )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 99.144 494.11 Td [(e)4 (nz)-15 (y)20 (me )]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 139.34 494.11 Td (to )Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 151.7 494.11 Td [(that of)3 ( the sol)-10 (uble e)6 (nz)-15 (y)20 (me is)]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 289.37 494.11 Td ( )Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 292.37 494.11 Td (\()Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 296.33 494.11 Td [(round)-6 (e)4 (d )-9 (off)6 ( to t)-3 (he)4 ( ne)4 (a)-5 (re)7 (st i)-4 (nte)-7 (g)10 (e)4 (r)]TJ ET Q q 93.384 491.11 452.14 41.4 re W* n BT 456.1 494.11 Td (\))Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 460.18 494.11 Td ( )Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 463.18 494.11 Td (_________)Tj ET Q q 93.384 491.11 452.14 41.4 re W* n BT 517.18 494.11 Td ( )Tj ET EMC Q Q BT /P <</MCID 15 >>BDC 54 473.11 Td ( )Tj EMC /P <</MCID 16 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 373.48 33.99 82.83 re W* n /P <</MCID 17 >>BDC q 59.4 373.49 33.984 82.824 re W* n BT 64.824 445.51 Td (Q.53)Tj ET Q q 59.4 373.49 33.984 82.824 re W* n BT /TT1 12 Tf 88.464 445.51 Td ( )Tj ET Q q 59.4 373.49 33.984 82.824 re W* n BT 100.82 445.51 Td ( )Tj ET EMC Q Q /P <</MCID 18 >>BDC q 93.39 373.49 452.13 82.824 re W* n BT 99.144 445.51 Td [(C)-2 (onsi)-2 (de)4 (r )-36 (a)4 ( )-39 (sim)-4 (ple )-37 (uni)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 205.61 445.51 Td (-)Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 209.57 445.51 Td [(su)-10 (bstra)4 (te )-37 (e)4 (nz)-25 (y)30 (m)-11 (e)4 ( )-39 (that )-39 (follo)-10 (ws )-38 (Micha)5 (e)4 (li)-3 (s)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 404.95 445.51 Td (-)Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 408.91 445.51 Td [(Me)3 (nten)-7 ( )-39 (kinetics. )-38 (W)-5 (he)4 (n )-39 (the )]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 99.144 431.71 Td [(e)4 (nz)-15 (y)20 (me )-117 (c)4 (a)4 (tal)-19 (y)30 (z)-15 (e)4 (d )-109 (re)-2 (a)4 (c)4 (ti)-13 (on )-109 (wa)6 (s )-110 (c)-5 (a)4 (rr)6 (ied)-7 ( )-109 (out )-111 (in )-111 (the )-107 (pre)7 (s)-10 (e)4 (nc)4 (e)4 ( )-109 (o)-9 (f )-106 (10 )-109 (nM )-120 (c)4 (o)-9 (nc)4 (e)4 (ntra)5 (ti)-3 (on )-109 (of )-116 (a)4 (n )]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 99.144 417.91 Td [(inhi)-3 (bit)-3 (or, )-316 (ther)5 (e)4 ( )-319 (wa)6 (s )-320 (no )-319 (c)4 (ha)4 (nge)4 ( )-319 (in )-321 (the )-317 (max)-7 (i)8 (m)8 (a)4 (l )-321 (ve)4 (locit)-11 (y)20 (. )-319 (How)4 (e)4 (v)-9 (e)4 (r, )-316 (t)-11 (he)4 ( )-319 (slope )-318 (of )-316 (the)12 ( )]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 99.144 404.11 Td [(L)11 (inew)-5 (e)4 (a)4 (v)-9 (e)4 (r)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 155.66 404.11 Td (-)Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 159.74 404.11 Td [(B)7 (urk )-46 (plot)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 205.97 404.11 Td ( )Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 209.57 404.11 Td [(in)-11 (c)4 (re)7 (a)4 (s)-10 (e)4 (d )-49 (3)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 264.53 404.11 Td (-)Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 268.49 404.11 Td [(fold. )-48 (Th)-8 (e)4 ( )-49 (diss)-3 (oc)4 (iation )-51 (c)4 (onst)-2 (a)4 (nt )-51 (for)6 ( )-49 (the )-47 (e)-5 (nz)-15 (y)30 (m)-11 (e)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 494.38 404.11 Td (-)Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 498.34 404.11 Td [(inhi)-3 (bit)-3 (or )]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 99.144 390.31 Td [(c)4 (ompl)-3 (e)4 (x)-9 ( )]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 143.54 390.31 Td (\()Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 147.5 390.31 Td (in nM\) )Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 183.53 390.31 Td (is )Tj ET Q q 93.39 373.49 452.13 82.824 re W* n BT 194.57 390.31 Td [(____)10 (_____)]TJ ET Q q 93.39 373.49 452.13 82.824 re W* n BT 248.45 390.31 Td ( )Tj ET EMC Q /P <</MCID 19 >>BDC q 93.39 373.48 452.13 82.83 re W* n BT 99.144 376.49 Td ( )Tj ET EMC Q BT /P <</MCID 20 >>BDC 54 355.49 Td ( )Tj EMC /P <</MCID 21 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 86.19 33.99 252.5 re W* n /P <</MCID 22 >>BDC q 59.4 86.184 33.984 252.5 re W* n BT 64.824 327.89 Td (Q.54)Tj ET Q q 59.4 86.184 33.984 252.5 re W* n BT /TT1 12 Tf 88.464 327.89 Td ( )Tj ET Q q 59.4 86.184 33.984 252.5 re W* n BT 100.82 327.89 Td ( )Tj ET EMC Q Q /P <</MCID 23 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 327.89 Td [(The)5 ( )-9 (produ)3 (c)4 (t )-11 (o)-9 (f )-6 (c)4 (ompl)-3 (e)4 (te)-7 ( )-19 (dig)8 (e)4 (sti)-4 (on )-9 (of )-6 (th)-11 (e)4 ( )-9 (plasmi)-2 (d )-19 (shown )-8 (be)4 (low )-9 (with )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT /TT3 12 Tf 431.74 327.89 Td [(Ec)5 (o)]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 450.34 327.89 Td [(R)-12 (I )-6 (a)4 (nd )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT /TT3 12 Tf 485.98 327.89 Td (Hae)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 506.14 327.89 Td [(II)6 (I)13 ( )-19 (wa)6 (s )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 99.144 314.09 Td [(purif)4 (ied )-297 (a)4 (nd )-299 (use)3 (d )-299 (a)4 (s )-300 (a)-5 ( )-299 (template)4 ( )-299 (in )-301 (a)4 ( )-299 (re)7 (a)4 (c)4 (ti)-3 (on )-299 (c)4 (ontaining)8 ( )-299 (Kle)4 (now )-297 (f)]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 451.3 314.09 Td [(ra)-2 (g)10 (ment )-299 (of )-296 (DN)4 (A)-7 ( )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 99.144 299.33 Td [(pol)-11 (y)20 (mer)-4 (a)4 (se)3 (, )-249 (d)-9 (NT)3 (P)-3 (s )-250 (a)4 (nd)-9 ( )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 226.25 299.33 Td ([)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT /C0_0 12 Tf 230.45 299.33 Td <0044>Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 237.77 299.33 Td <2D>Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT /TT0 8.04 Tf 0.06 Tc 241.73 303.89 Td (32)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 249.89 299.33 Td (P)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 256.61 299.33 Td (])Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 260.69 299.33 Td (-)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 264.65 299.33 Td [(dATP )-250 (in )-251 (a)4 ( )-249 (suit)-4 (a)4 (ble )-247 (re)-2 (a)4 (c)4 (ti)-3 (on )-249 (buf)-6 (fe)7 (r.)-6 ( )-249 (T)-8 (he)4 ( )-249 (produ)3 (c)4 (t)-11 ( )-249 (thus)7 ( )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 99.144 285.65 Td [(obtaine)4 (d wa)6 (s purif)3 (ied )-7 (a)4 (n)-9 (d subj)-2 (e)4 (c)4 (ted to ge)4 (l ele)-5 (c)4 (tro)-8 (phore)7 (sis)-3 ( followe)5 (d b)-19 (y)20 ( a)4 (ut)-11 (ora)7 (diogra)5 (ph)-19 (y)20 (. )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 525.82 285.65 Td ( )Tj ET EMC Q /P <</MCID 24 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 271.85 Td ( )Tj ET EMC Q /P <</MCID 25 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 489.1 141.5 Td ( )Tj ET EMC Q /P <</MCID 26 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 130.58 Td ( )Tj ET EMC Q /P <</MCID 27 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 116.78 Td ( )Tj ET EMC Q /P <</MCID 28 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 102.98 Td [(The)5 ( number)5 ( of b)-6 (a)4 (nds t)-2 (ha)-5 (t wil)-3 (l appe)6 (a)4 (r on the)5 ( X)]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 323.47 102.98 Td (-)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 327.43 102.98 Td [(ra)-2 (y)20 ( )-9 (film i)-4 (s )]TJ ET Q q 93.39 86.19 452.13 252.5 re W* n BT 379.75 102.98 Td (______)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 415.75 102.98 Td (___)Tj ET Q q 93.39 86.19 452.13 252.5 re W* n BT 433.78 102.98 Td ( )Tj ET EMC Q /P <</MCID 29 >>BDC q 93.39 86.19 452.13 252.5 re W* n BT 99.144 89.184 Td ( )Tj ET EMC Q BT /P <</MCID 30 >>BDC 54 68.184 Td ( )Tj EMC ET /P <</MCID 31 >>BDC q 87.6 567.36 463.56 116.52 re W* n q 69 0 0 47.52 284.88 622.56 cm /Im0 Do Q EMC Q /P <</MCID 32 >>BDC q 87.6 86.28 463.56 252.48 re W* n q 4.7117 0 0 1.77 149.76 141.48 cm /TT0 12 Tf 0 TL/Fm0 Do Q EMC Q /Artifact <</Attached [/Top ]/Subtype /Header /Type /Pagination >>BDC BT /TT0 8.04 Tf 54 798.36 Td [(G)5.995 (A)6.007 (T)13.993 (E )-3.993 (2)-6.007 (0)7.002 (1)-5.995 (8)7.002 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )2.45 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )10.983 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-3.01 ( )10.995 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )10.995 ( )-2.998 ( )-2.998 ( )-52.04 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-3.01 ( )11.007 ( )-3.01 ( )-2.985 ( )10.995 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )11.007 ( )-3.01 ( )-2.998 ( )10.995 ( )-3.01 ( )-2.985 ( )-3.01 ( )10.995 ( )-2.998 ( )-19.192 (B)-3.993 (i)-5 (o)6.99 (t)-5 (e)11.007 (c)10.995 (h)-5.995 (n)-6.007 (o)7.002 (l)9.005 (o)7.002 (g)-6.007 (y)3.321 ( )]TJ ET 52.56 795 490.44 0.48 re f* EMC /Artifact <</Attached [/Bottom ]/Subtype /Footer /Type /Pagination >>BDC BT 0.0373 Tc 54 37.824Tj 0 Tc 10.224 0 Td ( )Tj ET 52.56 46.104 317.95 0.48 re f* q 369.08 35.79 172.01 9.12 re W* n BT 0.06 Tc 522.82 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 530.86 37.704 Td (/)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT -0.06 Tc 533.14 37.704 Td (12)Tj ET Q q 369.08 35.79 172.01 9.12 re W* n BT 541.08 37.704 Td ( )Tj ET EMC Q BT /P <</MCID 0 >>BDC /TT0 12 Tf 54 776.88 Td ( )Tj EMC /P <</MCID 1 >>BDC 0 -13.8 Td ( )Tj EMC ET q 59.4 704.01 33.99 56.07 re W* n /P <</MCID 2 >>BDC q 59.4 704.02 33.984 56.064 re W* n BT 64.824 749.26 Td (Q.55)Tj ET Q q 59.4 704.02 33.984 56.064 re W* n BT /TT1 12 Tf 88.464 749.26 Td ( )Tj ET Q q 59.4 704.02 33.984 56.064 re W* n BT 100.82 749.26 Td ( )Tj ET EMC Q Q /P <</MCID 3 >>BDC q 93.39 704.02 452.13 56.064 re W* n BT 99.144 749.26 Td [(A )12 (rod )13 (sha)3 (pe)4 (d )10 (ba)-5 (c)4 (ter)5 (i)]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 198.29 749.26 Td (um)Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 213.65 749.26 Td ( )Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 216.65 749.26 Td [(ha)4 (s )9 (a)4 ( )10 (len)-7 (g)10 (th )8 (of )13 (2 )10 (\265)-3 (m)]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 314.59 749.26 Td [(, )10 (diame)4 (ter)5 ( )10 (of )13 (1 )10 (\265)-3 (m )8 (a)4 (nd )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 426.34 749.26 Td [(de)4 (nsit)-4 (y)20 ( )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 463.78 749.26 Td (the )Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 481.3 749.26 Td [(sa)3 (me a)6 (s )9 (that )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 99.144 735.46 Td [(of )-46 (wa)6 (ter)5 (. )-69 (I)13 (f )-46 (prote)5 (ins )-52 (c)4 (ons)-10 (ti)-3 (tut)-3 (e)4 ( )-49 (15%)3 ( )-49 (of )-46 (the )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 307.51 735.46 Td [(c)4 (e)4 (ll)-3 ( )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 328.39 735.46 Td [(mass )-49 (a)4 (nd )-49 (the )-47 (a)4 (ve)4 (r)-6 (a)-5 (g)10 (e)4 ( )-49 (prote)5 (i)-11 (n )-49 (ha)4 (s )-50 (a)4 ( )-49 (mass )-49 (of)-6 ( )]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 542.76 735.46 Td ( )Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 99.144 721.66 Td [(50 kDa)6 (, the numbe)4 (r o)-6 (f pr)-3 (oteins)]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 249.17 721.66 Td ( )Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 252.17 721.66 Td [(in t)-3 (he)4 ( c)4 (e)4 (ll)-3 ( is)]TJ ET Q q 93.39 704.02 452.13 56.064 re W* n BT 310.51 721.66 Td ( )Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 313.51 721.66 Td (_________)Tj ET Q q 93.39 704.02 452.13 56.064 re W* n BT 367.51 721.66 Td ( )Tj ET EMC Q /P <</MCID 4 >>BDC q 93.39 704.01 452.13 56.07 re W* n BT 99.144 706.9 Td [(\(1 D)5 (a)4 ( )]TJ ET Q q 93.39 704.01 452.13 56.07 re W* n BT 129.02 706.9 Td [(=)4 ( 1.6 )]TJ ET Q q 93.39 704.01 452.13 56.07 re W* n BT /C0_0 12 Tf 156.74 706.9 Td <0075>Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT 163.34 706.9 Td <20>Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT 166.34 706.9 Td <3130>Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT /TT0 8.04 Tf 178.34 711.46 Td (-)Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT /TT0 8.04 Tf 0.06 Tc 181.01 711.46 Td (24)Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT -0.12 Tc 189.17 706.9 Td (g\))Tj ET Q q 93.39 704.01 452.13 56.07 re W* n BT 199.13 706.9 Td ( )Tj ET EMC Q BT /P <</MCID 5 >>BDC /TT2 12.96 Tf 297.77 684.7 Td ( )Tj EMC /P <</MCID 6 >>BDC /TT0 11.04 Tf -243.77 -12.84 Td ( )Tj EMC /P <</MCID 7 >>BDC 0 -12.6 Td ( )Tj EMC /P <</MCID 8 >>BDC /TT2 12.96 Tf 144.77 -14.88 Td [(END OF )-8.002 (THE )-6.998 (QUES)-6.998 (TION PA)-8.002 (PER)-16.057 ( )]TJ EMC ET Q.No. Type Section Key/Range Marks 1 MCQ GA A 1 2 MCQ GA C 1 3 MCQ GA B 1 4 MCQ GA C 1 5 MCQ GA D 1 6 MCQ GA A 2 7 MCQ GA C 2 8 MCQ GA D 2 9 MCQ GA C 2 10 MCQ GA A 2 1 MCQ BT C 1 2 MCQ BT C 1 3 MCQ BT B 1 4 MCQ BT D 1 5 MCQ BT C 1 6 MCQ BT D 1 7 MCQ BT C 1 8 MCQ BT B 1 9 MCQ BT B 1 10 MCQ BT D 1 11 MCQ BT D 1 12 MCQ BT C 1 Q.No. Type Section Key/Range Marks 13 MCQ BT B 1 14 MCQ BT C 1 15 MCQ BT A 1 16 MCQ BT D 1 17 MCQ BT B 1 18 MCQ BT B 1 19 MCQ BT C 1 20 MCQ BT B 1 21 NAT BT ‐10 to ‐10 1 22 NAT BT 0.32 to 0.32 1 23 NAT BT 50 to 50 1 24 NAT BT 1 to 11 25 NAT BT 4096 to 4096 1 26 MCQ BT D 2 27 MCQ BT A 2 28 MCQ BT D 2 29 MCQ BT C 2 30 MCQ BT A 2 31 MCQ BT B 2 32 MCQ BT C 2 33 MCQ BT C 2 34 MCQ BT B 2 Q.No. Type Section Key/Range Marks 35 MCQ BT C 2 36 MCQ BT D 2 37 MCQ BT A 2 38 MCQ BT C 2 39 MCQ BT D 2 40 MCQ BT C 2 41 NAT BT 5.30 to 5.34 2 42 NAT BT 2.1 to 2.1 2 43 NAT BT 2.25 to 2.25 2 44 NAT BT 23.02 to 23.04 2 45 NAT BT 2 to 22 46 NAT BT 0.16 to 0.17 2 47 NAT BT 1 to 12 48 NAT BT 21.00 to 22.00 2 49 NAT BT 102.00 to 103.00 2 50 NAT BT 600 to 600 2 51 NAT BT 1.8 to 1.9 2 52 NAT BT 6 to 62 53 NAT BT 5 to 52 54 NAT BT 2 to 22 55 NAT BT 2900000 to 3200000 2

Biochemistry, Microbiology & Molecular Biology

Question 39 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 40 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 41 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 42 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 43 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 44 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 45 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 46 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 47 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 48 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 49 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 50 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 51 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 52 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 53 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 54 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 55 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 56 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 57 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 58 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 59 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 60 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 61 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 62 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 63 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 64 from official GATE BT 2018 Examination.

Biochemistry, Microbiology & Molecular Biology

Question 65 from official GATE BT 2018 Examination.