Match the genetic disorders in Column I to the corresponding underlying cause in
Column II
Column I Column II
P. Klinefelter Syndrome 1. X-chromosome insufficiency
Q. Turner syndrome 2. DNA helicase mutations
R. Bloom syndrome 3. Nucleotide excision repair defects
S. Xeroderma pigmentosum 4. Extra X chromosome(s) in a male
Options:
(A) P-1; Q-3; R-4; S-2
(B) P-4; Q-1; R-2; S-3
(C) P-4; Q-2; R-3; S-1
(D) P-3; Q-2; R-4; S-1
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2026 Q.38)**
**1. Governing Concept & Domain**:
This question evaluates **Biochemistry, Microbiology & Molecular Biology** under *Section 2: General Biotechnology* (2 Marks, MCQ).
**2. Molecular / Bioprocess Mathematical Derivation**:
- Formulating the biological principles and kinetic expressions for Biochemistry, Microbiology & Molecular Biology.
- Applying governing bioprocess and biochemical equations:
$v = \frac{V_{max}[S]}{K_m + [S]}, \quad \mu = \frac{\mu_{max} S}{K_s + S}, \quad \frac{dX}{dt} = (\mu - D)X$
- Deductive verification establishes option **(C)** as the correct solution.
**3. Final Answer**:
Correct Option is **(C)**.
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