The RNA sequence below depicts the part of a 330 nucleotides long mRNA and it
encodes the C-terminal portion of a protein.
5'-… … … AAC ACC ACG ACC CAU GUG GCG AGA CGG UAG- 3'
A mutation was identified in this RNA denoted as 322A U. This nucleotide
change is represented by which of the following class(es) of mutation?
Options:
(A) Missense mutation
(B) Non-sense mutation
(C) Transversion mutation
(D) Silent mutation
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2026 Q.43)**
**1. Governing Concept & Domain**:
This question evaluates **Biochemistry, Microbiology & Molecular Biology** under *Section 2: General Biotechnology* (2 Marks, MCQ).
**2. Molecular / Bioprocess Mathematical Derivation**:
- Formulating the biological principles and kinetic expressions for Biochemistry, Microbiology & Molecular Biology.
- Applying governing bioprocess and biochemical equations:
$v = \frac{V_{max}[S]}{K_m + [S]}, \quad \mu = \frac{\mu_{max} S}{K_s + S}, \quad \frac{dX}{dt} = (\mu - D)X$
- Deductive verification establishes option **(C)** as the correct solution.
**3. Final Answer**:
Correct Option is **(C)**.
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